Thomas Stehlé

T50 and Calcification Progression in Kidney Transplant Recipients: Does it have to be “bad” to be useful? The increased risk of cardiovascular disease (CVD) among kidney transplant recipients (KTR)1 is challenging for the treating physician. For KTR, CVD risk remains higher than for individuals with simil...

A little opinion piece on the relationship between serum calcification propensity (T50) and progressive CAC in kidney transplant recipients 🤓
www.kireports.org/article/S246...

www.jle.com/10.1684/ndt....

Check out the new KDIGO IgAN/IgAV Guideline Key Takeaways!

IgAN: kdigo.co/KDIGO-IgAN-G...

IgAV: kdigo.co/KDIGO-Guidel...

These resources are designed to provide clinicians with quick and practical access to the most important points from the new KDIGO guideline on managing #IgAN and #IgAV.

Congratulations to Michael Moryoussef for this first original study, to Antoine Morel, the statistician in chief for this work ;-), and to all the co-authors.

In addition to diabetes and male gender, we identified myosteatosis and low muscle mass as predisposing factors. Visceral and subcutaneous fat mass were not determinants of the low ratio.

We show that a low eGFR ratio is associated with the occurrence of major cardiovascular events, whether using CKD-EPI or EKFC equations.

The originality of this study also lies in our attempt to identify the determinants of such a low ratio by including body composition data in the analyses.

Very pleased to share this publication from @hophenrimondor.bsky.social .
A low eGFRcys/eGFRcr ratio is increasingly recognized as a risk factor for morbidity and mortality, including CV events.
However, there was little or no data available on kidney transplantation.

Low Cystatin C–to–Creatinine Estimated GFR Ratio Predicts Post–Kidney Transplant Cardiovascular Events A low cystatin C–based to creatinine-based estimated glomerular filtration rate (eGFR) ratio (eGFRcys/eGFRcr) is associated with poor clinical outcomes, but data in kidney transplant recipients (KTRs)...

Low Cystatin C–to–Creatinine Estimated GFR Ratio Predicts Post–Kidney Transplant Cardiovascular Events - Kidney International Reports www.kireports.org/article/S246...

Nice example of urate crystals in gouty tophi involving the medulla. Polarizable crystals can be see using unstained sections from the IF tissue. #renalpath #pathsky #nephsky

The Maltese Cross 🇲🇹🛡️sign is not unique to lipids, other structures can manifest it under polarized light (eg, starch, leucine crystals). Here, a rare sighting of a cast containing suspected ciprofloxacin crystals. #UrinarySediment #UrineMicroscopy #PisseProphet

Bravo Antoine pour cet édito avec deux co auteurs prestigieux !

La coordination de prélèvement d’organes était hier au marché de Créteil pour la Journée Nationale Du Don d’organes. Rendez-vous ce mercredi 25 juin à l’hôpital Henri-Mondor, hall principal, de 9h à 16h30 pour en savoir plus et se sensibiliser !
@ap-hp.bsky.social

Needle selection in kidney biopsy requires balancing risk of complications with benefit of obtaining diagnostic tissue. Study shows that higher needle gauge provides more tissue for diagnosis but might be associated with greater risk of complications. https://bit.ly/KID0835
#ASNKidney360

The least-squares mean percent changes in body weight

Presented at #ECO2025:

In the SURMOUNT-5 phase 3b trial involving adults with obesity without type 2 diabetes, tirzepatide was superior to semaglutide in reducing body weight and waist circumference. Full trial results: nej.md/44ZeMPz

@easoobesity.bsky.social

Confirmatory Testing for Primary Aldosteronism: A Study of Diagnostic Test Accuracy: Annals of Internal Medicine: Vol 0, No 0 Background: Confirmatory testing to verify the diagnosis of primary aldosteronism (PA) in patients who have an abnormal screening result is of uncertain benefit. Objective: To perform a blinded assess...

In the @annalsofim.bsky.social

www.acpjournals.org/doi/10.7326/... from @ucalgarymed.bsky.social team

Saline suppression test not useful in confirming primary #aldosteronism - go straight to AVS if planning Sx (and ramp up MRA to target renin if Medical management)

#NephSky #EndoSky

Urea to Treat Hyponatremia Due to Syndrome of Inappropriate Antidiuretic Hormone Secretion: A Systematic Review and Meta-Analysis

bit.ly/3XM0b53

While frailty is often difficult to identify, myosteatosis is easy to detect on the basis of unenhanced abdominal CT scans performed as part of routine care.

We previously showed that myosteatosis was associated with mortality after kidney transplantation (10.1002/jcsm.12853).
It is therefore likely that myosteatosis is associated with frailty, in addition to cardiovascular risk.

Myosteatosis as a New Risk Factor of Surgical Complications in Kidney Transplant Recipients: A Retrospective Study Background Computed tomography (CT) scan–defined myosteatosis is a common feature in ESKD patients receiving kidney transplantation (KT) and is associated with mortality after KT. We aimed to explor...

Myosteatosis, the infiltration of fat into muscles, is associated with the risk of surgical complications after kidney transplantation.

This is what we have shown in this study involving the nephrology, radiology and urology departments at @hophenrimondor.bsky.social .

doi.org/10.1002/jcsm...

Discordant Results Between Creatinine- and Cystatin C-based Equations for Estimating GFR Discordant results between cystatin C and creatinine in estimating glomerular filtration rate (GFR) are an important medical issue. However, the equat…

Discrepancies between creatinine- and cystatin C-based equations:
Less dicrepancies with EKFC (and LMR) equations than with CKD-EPI equations!
free access
thanks to all co-authors
www.sciencedirect.com/science/arti...

Interested in learning more about the art of microscopic examination of the urinary sediment and its clinical applications? @jrseltzer.bsky.social @swethakanduri.bsky.social and I will be running a Hands-On Workshop at KidneyCon this year. Come join us! @kidneycon.bsky.social May 1-3. Register ASAP

Diabetic status and the performances of creatinine- and cystatin C–based eGFR equations ABSTRACTBackground. The estimation of glomerular filtration rate (GFR) is one tool to detect renal disease. The most used biomarker remains serum creatinin

One question was still open: is the diabetic status (in itself) influencing the performance of eGFR? We show the answer is No

academic.oup.com/ndt/article/...
@tstehle.bsky.social

Insights from the BKEVER Trial comparing everolimus versus mycophenolate mofetil for BK Polyomavirus infection in kidney transplant recipients The MTOR inhibitors have demonstrated antiviral properties, and prior non-randomized studies have suggested they may have a suppressive effect on BKPyV replication. Here, in this randomized, multicent...

Enfin un papier qui répond de façon claire à ce qu'on soit faire devant du BK virus. Réduire l'IS et ne pas mettre d'everolimus. Bravo aux auteurs.
www.kidney-international.org/article/S008...

➡️ A Targeted Release Capsule of Lanthanum Carbonate: a New Efficient Cheap Treatment for Primary Hyperoxalurias www.kireports.org/ar...

This GFR calculator, available on the French-speaking Nephrology Society website, includes EKFC equations in addition to CKDEPI equations, as well as pediatric equations. It can be used across the whole age spectrum, even by non-French-speaking nephrologists! www.sfndt.org/professionne...

Enhancing individual glomerular filtration rate assessment: can we trust the equation? Development and validation of machine learning models to assess the trustworthiness of estimated GFR compared to ... Background Creatinine-based estimated glomerular filtration rate (eGFR) equations are widely used in clinical practice but exhibit inherent limitations. On the other side, measuring GFR is time consum...

Can we trust eGFR results? The answer of IA !
bmcnephrol.biomedcentral.com/articles/10....
trustekfcegfr.shinyapps.io/GFR_shiny_La...

Thanks to the EKFC!
Thanks to Antoine Lanot

1/Hey #NephSky! Welcome to a 🆕 #MedSky #Skytorial brought to you by @kireports.bsky.social @isnkidneycare.bsky.social! Our author is @elbaonelida.bsky.social nephrologist at Hospital General de Mexico @hgm_nefrologia. Please also check out #KIReportsCommunity educational #blogposts. FOLLOW US!

a woman wearing a black shirt with butterflies on it says a repeating pattern with her hands in the air ALT: a woman wearing a black shirt with butterflies on it says a repeating pattern with her hands in the air

1/n One of the things that I find valuable in internal medicine in general is pattern recognition. And nephrology is not the exception. AKIs come in different flavors, we can smell the etiology based on the presentation and the way the serum Cr (sCr) rises.

Misclassification of Hypertension Status According to Office Blood Pressure versus 24-Hour Ambulatory Blood Pressure Monitoring Ambulatory blood pressure monitoring (ABPM) is the “gold standard” for establishing the diagnosis of hypertension yet remains under-utilized in Canada…

Misclassification of Hypertension Status According to Office #BloodPressure vs 24 #ABPM

#CardioSky #MedSky #NephSky ❤️seeing further studies confirm the power of #ABPM for #hypertension control!

Congratulations @hswapnil.bsky.social & coauthors

www.sciencedirect.com/science/arti...