The most important #RNA conference of the year with lots of amazing science and a really friendly atmosphere. This year in beautiful Montreal 🇨🇦 !
www2.rnasociety.org
Canada 🇨🇦 vs US 🇺🇸 Olympic gold medal final overtime
🐅
Congrats Michael!
Tetrad dissection
📣 The 2026 Midwest DNA Repair Symposium is coming to Kansas City (registration is open)
🗓 May 30–31, 2026
✨ Talks will be selected from abstracts, with a strong focus on trainees and new investigators.
Please RT & share with your labs!
🔗 sites.google.com/view/kumc-mi...
Great response so far for the DNA Repair Meeting in April 2026 ! 🧬
A few poster spots are still available.
✨ Early-bird registration extended to February 28th
✨ New invited speakers added: check the site: dnarepairmeeting-egmond2026.com
Don’t miss this outstanding meeting!
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To all DNA repair aficionados 🧬 who want to attend the Egmond Repair Meeting in April 2026:
The deadline for early registration is January 10th, 2026! 🗓️
Sign up soon to benefit from the early-bird registration fee 🐦💸
See you all in Egmond! 🌊✨
That will be fun to explore!
Congrats Susi!
How can we scale subcellular spatial proteomics across many experiments and conditions?
Our new paper presents a genetic algorithm and evaluation framework that optimizes bait subsets for proximity proteomics platforms like BioID enabling context-specific proteome mapping.
9 days to go:
* 2 x open positions!
* Exceptional environment, competitive start-up package
* University of Toronto appointments
* Toronto has great (and peaceful) quality of life!
Kickstarting our Bluesky🦋 account with great news!
Our REPAIRome study finally out today in
@science.org
www.science.org/doi/10.1126/...
We are looking for our next PhD student to join us 🤩 www.mcclellandlab.com to understand cancer radiation therapy's impact on DNA damage repair and chromosomal instability. Prestigious funding from CRUK RadNet. Please contact me informally - deadline 5th Nov! crukradnet.colcc.ac.uk/phd-students...
I suppose it is a calibration tool for food chemistry labs (calories, texture, content) but it's wild indeed!
I really wonder what a $2K set of peanut butter jars from the NATIONAL INSTITUTES OF STANDARDS & TECHNOLOGY could be for?
The Garnett Lab is excited to launch DepMap Miner, a new tool to explore cancer dependency data!
Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models.
Start mining data now: dataminer.depmap.sanger.ac.uk
Happy to share our latest research on the BRCA1-BRCTs now online.
academic.oup.com/nar/article/...
Congrats to first author Venda for putting it all together! This project was a great collaboration with the @titiasixma.bsky.social lab who helped us give structural meaning to our observations.
Kaima Tsukuda and @andrewblackford.bsky.social have a highly complementary study that indicates that mutations in DDIAS (and CIP2A) caused neurodevelopmental defects, pointing a role for this pathway in development. /fin
www.biorxiv.org/content/10.1...
Thanks to all authors and collaborators, chiefly @yiboxue.bsky.social but that's not all!
Why is an ssDNA-binding protein involved in the CIP2A pathway? Our data suggests it may be to prevent ssDNA from accumulating in mitosis.
We propose that mitotic ssDNA is a liability for the integrity of chromosomes during cell division, and that a function of CIP2A-TOPBP1-DDIAS is suppress it.
We were puzzled by the fact that DDIAS has an OB-fold domain which often acts as an ssDNA-binding domain.
We find that DDIAS binds to ssDNA. This activity is not involved in its recruitment to DNA damage sites, but it is necessary for its function in genome maintenance.
Like CIP2A, DDIAS accumulates at DNA lesions specifically during mitosis, and it is recruited to the CIP2A-TOPBP1 complex via a phosho-dependent interaction with the TOPBP1 C-terminus.
DDIAS loss, like that of CIP2A, impairs the viability of BRCA1/2-deficient cells.
New work from the lab! 🔬
We report that DDIAS is a new component of the mitotic CIP2A-TOPBP1 pathway of genome maintenance. 1/n
www.biorxiv.org/content/10.1...
Excited to share our lab’s latest preprint! We identify DDIAS as a novel single-stranded DNA-binding component of the TOPBP1–CIP2A complex, which acts in a mitotic DNA damage response pathway to protect chromosome integrity. Short summary below, and read it here: www.biorxiv.org/content/10.1...
Job Alert 🚨
Are you an emerging leader in biomedical discovery or population health data science?
We are looking for outstanding candidates to join our institute!
Learn more & apply:
Biomedical Discovery ➡️ apply.interfolio.com/172703
Population Health Data Science ➡️ apply.interfolio.com/172529
Wishing you many more!
New from @hartjackson.bsky.social: 104‑plex #IMC on 3 serial PDAC sections, 200+ patients, whole-slide & cellular modes. Spatial proteomics guides LCM + genomics to define tumor–immune–stromal spectra. A tour de force.
biorxiv.org/content/10.1...
@standardbiology.bsky.social #SpatialBio #IMC
JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
www.nature.com/naturecareer...
Please repost!
