Claus Ernst

Ich bin einfach nur sprachlos: diese radikale Frau, einst CDU-Ministerin, längst AfD-EhrenhalberMitglied, will dringend benötigte Grundversorgung von Behinderten abschaffen - Eugenik auf Filzlatschen. Wohin steuert die CDU?

NEUE STUDIE: Das Risiko für Long COVID hat sich im Laufe der Zeit nicht verringert

„Diese Studie widerlegt eindeutig die Annahme, dass das Risiko für Long COVID im Laufe der Zeit abgenommen hat. Die Tatsache, dass das Risiko, Anfang 2024 an Long COVID zu erkranken, laut Studie…

Ich warte mit Spannung darauf, wann sich die österr. Gesundheitspolitik dann künftig auf eine Definition von „Krebs“ oder „Herzinsuffizienz“ einigt, schließlich brauchen wir wohl den Segen der Zielsteuerungsgremien, wenn medizinische Klassifikationen nicht mehr ausreichen.

Occupational determinants of Long COVID in the population-based COVICAT cohort Objectives Occupational factors affect SARS-CoV-2 infection risk, but the occupational factors associated with Long COVID (LC) are unknown. We aimed to address this issue using individual data in a po...

Es wäre wenig überraschend, aber dieser Artikel liefert Hinweise, dass berufliche Exposition, selteneres Tragen von FFP2 und Verwendung von öffentlichen Verkehrsmitteln mit einem höheren Risiko für #LongCovid assoziiert waren (LC-Definition unpräzise).

oem.bmj.com/content/earl...

Fascinating paper from Manuel Ruiz Pablos Bruno Paiva, showing that the survivor genes of our ancestors may be responsible for our overactive immune systems getting out of whack and the host developing autoimmune diseases such as #longcovid #mecfs #myalgicencephalomyelitis #postvac.

SARS-CoV-2 Leaves a Lasting Mark on the Immune System A landmark new study shows COVID-19 isn’t ‘just a cold’: One infection left people with long-lasting immune damage, and those with heart disease lost up to 70% of key immune cells. Reinfections may wo...

“Jiang and colleagues conclude, carefully but clearly, that their findings ‘redefine SARS-CoV-2 infection as a condition of long-lasting immune compromise’ and highlight lymphocyte dysregulation as a key immunological feature of Long Covid, particularly in people with cardiovascular disease.”

Systems Immunology of Long Covid: Insights from the STOP-PASC Clinical Trial Background Post Acute Sequelae of COVID-19 (PASC), also referred to as Long COVID, is an infection-associated chronic syndrome with heterogenous symptom profiles that occurs in a subset of people foll...

Stanford researchers found no clear signs of autoimmunity, EBV reactivation, or microclots in 152 Long COVID patients

They saw lasting immune activation in monocytes, neutrophils, and T/NK cells, even though Paxlovid caused only short-term immune shifts

www.medrxiv.org/content/10.6...

Ich finde an der Studie gut, dass die gestörte Immunregulation von Long COVID erwähnt wird. Das sind ja immerhin auch bis zu 400 Mio. Betroffene weltweit.

1️⃣ Visible Health has launched a local clinical trial feature. One of the first surfacing to users is an ACT (Acceptance & Commitment Therapy) trial led by Trudie Chalder, a researcher whose work has been highly controversial in ME. This raises important patient-safety concerns.

What? Genau das macht die Studie teilweise. Cardiovascular Disease wird gegen sich selbst verglichen. Nochmal in Ruhe lesen.

A few thoughts on Zhengqi J. et al., “Persistent Attenuation of Lymphocyte Subsets After Mass SARS-CoV-2 Infection”
doi: doi.org/10.1016/j.ij...
#PAIS #LongCOVID #Immunology #ChronicInfection #ImmuneExhaustion

It is a large study (n=40,537) from China.
1/10

"suggest that chronic immune depletion or exhaustion may directly contribute to the persistence of #longCOVID symptoms."

"Prolonged CD4⁺ and CD8⁺ T-cell depletion resembles immune patterns seen in post-viral fatigue syndromes (e.g., #MyalgicEncephalomyelitis), which share hallmark symptoms such as fatigue and cognitive impairment. These prolonged lymphocyte subset perturbations, now robustly documented in our cohort "

"precipitate microvascular thrombosis, and SARS-CoV-2 spike protein receptor-binding domain (RBD) -induced platelet activation/clearance via αIIbβ3 integrin binding–processes that may act synergistically or sequentially to sustain symptoms."

"Our findings support immune dysregulation is a central driver of long COVID pathogenesis, likely mediated by interconnected mechanisms. For example, immunosuppression during acute infection may permit SARS-CoV-2 persistence, while endothelial dysfunction could ">

"Additionally, studies have shown that anti-RBD antibody levels significantly decline in 80% of patients 10 months after initial infection, indicating a significantly higher risk of reinfection.">

"The high infectivity and variability of SARS-CoV-2 have made subsequent infections inevitable, with accumulating evidence suggesting that repeat exposure increases the severity and incidence of #longCOVID. " >

"These findings highlight the differential effects of SARS-CoV-2 on distinct T-cell subsets across different phases, reflecting a dynamic immune response." >

"This suggests that CD8+ T cells depletion occurs early, likely due to viral-induced apoptosis or T-cell exhaustion, followed by a later decline of CD4+ T cells may also be affected, possibly driven by chronic immune activation or reduced thymic output. " >

"Changes in the CD4+/CD8+ T-cell ratios provide further insight. While a reduced CD4+/CD8+ T-cell ratio has been described in chronic viral infections such as HIV, [36] our study found that the ratio was increased during the mass infection phase before declining in the post-COVID phase. " >

"The observed decrease in NK cells further supports this hypothesis, which aligns with studies suggesting a reactivation of latent pathogens, such as Epstein-Barr virus (EBV) and human herpesvirus 6 (HHV-6), in patients with #LongCOVID"

"Such alterations may impair the immune system’s ability to mount an effective response against latent infections, thereby increasing susceptibility to opportunistic pathogens. " >

"impaired T-cell maturation, increased apoptosis, or prolonged immune activation. This is consistent with reports that SARS-CoV-2 persistence in tissues contributes to long-term immune remodeling, similar to what is seen in chronic viral infections" >

"a disproportionately greater loss of T cells, which consequently reshaped the compositional landscape of circulating lymphocytes.

[...] even a short, widespread SARS-CoV-2 outbreak can lead to prolonged lymphocyte dysregulation, which is potentially driven by " >

"reactivation of latent infections, and autoimmunity–all mechanisms linked to #LongCOVID pathogenesis. Notably, increase in the percentage of a subset (e.g., B cells) despite a decrease in its absolute count, reflecting a severe reduction in the total lymphocyte and " >

"Meanwhile, the proportion below the normal range was dramatically increased, particularly CD4+ and CD8+ T cells. Persistent reductions in CD8+ T cells, CD4+ T cells, and total T cells suggest chronic immune dysfunction, potentially predisposing individuals to immune exhaustion, ">

"Compared to baseline levels, significant decreases were observed in the absolute counts of CD4+ T cells, CD8+ T cells, NK cells, and total T cells, with sustained alterations in the CD4+/CD8+ T-cell ratio. ">

"Regarding the phenomenon of long-term lymphopenia, previous studies demonstrating robust activation of CD8⁺ T cells alongside unaltered TREC (T cell Receptor excision circle) indicate that activation-induced apoptosis plays an important role."

"[...] key immune populations, including CD4+ T cells, CD8+ T cells, NK cells, and total T cells, exhibit persistently unrecovered for up to 20 months post-exposure, underscoring the potential role of immune dysregulation in the development and persistence of #LongCOVID symptoms. " >

"This suggests a potential long-term impact of SARS-CoV-2 on the adaptive immune system, possibly contributing to #LongCOVID."