Evangelia Petsalaki

Staff Scientist About EMBL-EBI EMBL’s European Bioinformatics Institute is a data powerhouse, utilised on a global scale to advance scientific discovery through bioinformatics and solutions to some of the world’s mos...

I am hiring! - looking for a Staff Scientist to co-run my research group with me. Staff Scientist is a senior professional scientist role at EMBL. Please forward to people you might know who could be interested! embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Mechanism of MEK1 phosphorylation by the N-terminal acidic motif-mediated asymmetric BRAF dimer The RAF/MEK/ERK signaling cascade regulates cell proliferation and differentiation and is frequently dysregulated in cancer. Approximately 90% of RAF-mutant cancers harbour mutations in B-type of Rapi...

Skeetorial on our BRAF preprint!
tinyurl.com/asymmBRAF
The RAS->RAF->MEK->ERK cascade carries mutations in most human cancers. Interestingly, although we have three RAF paralogues (A, B and C), it is the BRAF that is predominantly mutated in cancer patients. (1/10)

Happening now at GIMM Lisbon 🧠✨
Our "Science meets the Media" workshop is underway - featuring the experienced and inspiring contributions of our collaborators Oana Stroe (EMBL-EBI), Omar Jamshed (CRG), and Sara Sá (GIMM).

#BIOMICSproject #GIMM #ScienceCommunication #Bioinformatics #Workshop

Building Immune Digital Twins: An International and Transdisciplinary Community Effort Digital twins, initially developed for industrial applications, are set to make significant advancements in medicine and healthcare. They have demonstrated promising potential for drug development and...

By Niarakis et al., including:
@athinacp.bsky.social
@eirini-tsirvouli.bsky.social
@hasanbalci.bsky.social
@ozanozisik.bsky.social
@arnaumontagud.bsky.social
@subbannayya.bsky.social
@mkutmon.bsky.social

Learn about their 5-year plan: www.immunoinformaticsjournal.com/article/S266...

Early career group leaders We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.

The @crick.ac.uk is recruiting Early Career Group Leaders

- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology

Deadline 27 Nov

www.crick.ac.uk/careers-stud...

The functional landscape of the human ubiquitinome Protein ubiquitination regulates cell biology through diverse avenues, from quality control-linked protein degradation to signaling functions such as modulating protein-protein interactions and enzyme...

new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...

Join us in our plenary #seminar tomorrow, with Maria Tsoumakdou, MD PhD, from BSRC Alexander Fleming and National & Kapodistrian University of Athens University of Athens.

Host: Dr. @batllelab.bsky.social 

Register here ➡️ https://shorturl.at/HNwEM

#CancerResearch #CancerImmunology

🧪

🥁 Check out our new preprint on OmniPath, the prior knowledge resource for #SystemsBiology, and its brand-new OmniPath Explorer web app! 🥳

📖 Preprint: www.biorxiv.org/content/10.1...
🔍 Explorer: explore.omnipathdb.org

OmniPath integrates 160+ resources for multi-omics analysis & modeling.

🧶⬇️

Our group has a PhD position open in this Doctoral network. Our topic is around combining proteomics AI and protein structures. Look through the website below to look at all of the projects/groups and apply.

There is a position open in our lab, within this network. Our project deals with assessing identification and quantification errors for MS-based proteomics. www.protaiomics.eu/project/dc13...
Please check out all the project descriptions at the site below:

A comprehensive genetic catalog of human double-strand break repair The analysis of DNA sequence outcomes provides molecular insights into double-strand break (DSB) repair mechanisms. Using parallel in-pool profiling of Cas9-induced insertions and deletions (indels) w...

Kickstarting our Bluesky🦋 account with great news!
Our REPAIRome study finally out today in
@science.org
www.science.org/doi/10.1126/...

YouTube video by BIOMICS Twinning Getting to know BIOMICS members: Pedro Beltrão

✨ Getting to know BIOMICS members ✨
Meet the people behind our #Twinning project one story at a time.
🎙️ Who’s our first guest?
Hint: a Group Leader at ETH Zurich exploring how molecular mechanisms shape human biology and disease.

Here ➡️ youtu.be/iqlB74ldyos
#HorizonEurope #BIOMICS #MeetTheTeam

@nmoraislab.bsky.social @pedrobeltrao.bsky.social @mirimiam.bsky.social @epetsalaki.bsky.social

Excited to present my talk "Data-Driven Mathematical Modelling to Improve Heart Organoid Design" in the Therapeutic Target Discovery module at #ICSB2025 in Dublin tomorrow at 3:20 pm! 🫀💻 @epetsalaki.bsky.social @ebi.embl.org

Also don’t miss:
🧬👯 @epetsalaki.bsky.social’s talk “From Data to Digital Twins” (Wed, Digital Twin Models)

📊🧬 My poster P03.14 – Towards Data-Driven Executable Models (Wed)

🧩🤖 @alussana.bsky.social’s poster P18.13 – Data-Driven Inference of Functionally Coherent Gene Modules (Mon)

Now published, our tool to run (almost) all biological models interactively in your web browser

Paper: academic.oup.com/bioinformati...
Website: biomodels.bacpop.org
Code: github.com/bacpop/SBMLt...

Systematic Discovery of Motif-based Interactions of the Auxiliary Domains of USP Family Deubiquitinases The ubiquitin-specific proteases (USPs) family is the largest family of human deubiquitinating enzymes (DUBs). While most USPs are agnostic to polyubiquitin linkage-type, their substrate specificity i...

Finally out! Thrilled to share our collaboration with @kulathu.bsky.social, @orafurman.bsky.social, and N Davey. We screened auxiliary domains of USP family #deubiquitinases, revealing short linear motifs (SLiMs), contributing to specificity in complex assembly.
www.biorxiv.org/content/10.1...

Join us for this exciting meeting!

The registration and abstract submission for the "High-Content CRISPR Screening" conference on March 18–19, 2026, in Vienna, Austria is now open! Secure your spot via the conference website... The registration and abstract submission for the "High-Content CRISPR Screening" conference on March 18–19, 2026, in Vienna, Austria is now open! Secure your spot via the conference website: https://...

Francesco will be speaking at the High-Content CRISPR Screening conference, taking place March 18–19, 2026 in Vienna 🇦🇹 alongside leading experts in CRISPR screening, functional genomics, and drug discovery
www.linkedin.com/posts/myllia...

For additional open calls for leadership roles at EMBL, also check out: embl.wd103.myworkdayjobs.com/EMBL

We’re looking for:
Hamburg: Group Leader
Grenoble: Group Leader
Heidelberg: Two Group Leaders, Team Leader, Unit Head

Call for Applications / Ausschreibung

Springboard for an international scientific career! 🧬🧪🔭⚛️🧠🌱 Call for #MaxPlanckResearchGroups launched; applications are possible until October 14, 2025 www.mpg.de/max-planck-r... #ScienceCareer

🚨 New in PNAS!
🧬 64% of disease co-occurrences can be explained by transcriptomic similarities.

Comorbidities aren’t random—they have a molecular basis.

Here’s how we found it 👇 (1/n)

🔗 doi.org/10.1073/pnas.2421060122

@alfonsovalencia.bsky.social

📢 Recruitment for the EMBL International PhD Programme is officially open!

At EMBL, we train young scientists to become skilled and creative future leaders in academia and other sectors. Join us and get a head start on your career in life sciences!

bit.ly/47mmiFF

'The Computation & Theory research area at Janelia seeks exceptional Group Leaders to advance our understanding of complex biological systems through theory, computational modeling, multi-modal data integration, and interpretable machine learning.'
#ScienceJobs
www.janelia.org/content/lead...

Image of Toronto

JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.

www.nature.com/naturecareer...

Please repost!

A global genetic interaction map of a human cell reveals conserved principles of genetic networks We generated a genome-scale, genetic interaction network from the analysis of more than 4 million double mutants in the haploid human cell line, HAP1. The network maps ∼90,000 genetic interactions, in...

Monumental effort from @maxbillmann.bsky.social and colleagues, quantifying genetic interactions among 4 million human gene pairs. Lots of features associated with genetic interaction & GI degree conserved from yeast. www.biorxiv.org/content/10.1...

Very happy to have collaborated with Yifei and Jaime in these exciting projects!

Helmholtz Munich Helmholtz Munich, is a member of the Helmholtz Association of German Research Centres

Thrilled to collaborate with Mathew Garnett @Sanger and Parse Biosciences on the new Cancer Plasticity Atlas – a hugely exciting single cell genomics resource to decode tumor adaptation. 🔗 helmholtz-munich.de/en/newsroom/news-all/artikel/cancer-plasticity-atlas-to-improve-cancer-therapies

Deadline this Sunday!

Having held this position for almost three years, I can say it’s a super friendly and fun committee to be involved in! Reach out if you have any questions 🙂