Lyssiotis Lab

Photo of a tv. Onscreen a woman holds an axe with a periodic table visible behind.

Buffy is so old there were only 103 named elements, we’re at 118 now.

(Yes I pause every show that has a periodic table to see if its period accurate)

May the odds be ever in your favor.
4% payline at the NCI.

www.cancer.gov/grants-train...

PO just confirmed that our 5th percentile R01 is not getting funded. Past NCI Payline at 4 percent. Cant believe it.

Fifteen years later, Science retracts ‘arsenic life’ paper despite study authors’ protests Belated decision on widely disputed 2010 study pleases some critics but puzzles and dismays others

Science finally retracts the Arsenic life paper www.science.org/content/arti...

Look forward to seeing you there 🙌🏼

Congrats on this awesome work! (Got ya on Twitter, here too now 😊)

Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate in the lung where they inhibit CD8+ T cells, promote fibr...

Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes” was published today in @emboreports.org, describing how neutrophil metabolism influences niche priming to support metastasis (1/14) www.embopress.org/doi/full/10....

2025 Midwest Metabolism Meeting Join us for 2025 Midwest Metabolism Meeting at Van Andel Institute Stay informed about exciting upcoming events and activities.

3/ Students and postdocs, take note: 75% of the talks will be from trainees. Registration is open and free, and we are actively soliciting abstracts.

🙏🏼🔁 and share widely!

2/ The combined 2-day event will be at the University of Michigan, with co-sponsorship by the VAI Institute.

2025 Midwest Metabolism Meeting Join us for 2025 Midwest Metabolism Meeting at Van Andel Institute Stay informed about exciting upcoming events and activities.

1/ If you are in the Midwest and ❤️ metabolism, take note!

This year’s Midwest Metabolism meeting will be held jointly with the Translational Research in Mitochondrial Metabolism in Aging and Disease (TRiMAD) conference.

www.vai.org/event/2025-m...

🙏🏼😊

🙏🏼😊

🙏🏼😊

So grateful and excited to partner with the Stephenson Global Pancreatic Cancer Research Institute to advance our collaborative program targeting lysosome and Kras metabolism in pancreatic cancer!

michmed.org/rwVDK

Giant study finds a research field that’s mostly reproducible Researchers assessed more than 1,000 results from fruit-fly immunity research published between 1959 and 2011. The majority of findings look verifiable.

Model organism communities are fantastic. Good work, "Drosophilists"! www.nature.com/articles/d41...

Hey @nature.com What's up with your share buttons? Can we please also get 🦋 and 🦣 options to not exclusively promote the network of the guy who has done more than most to harm US science?

Microbiota-driven antitumour immunity mediated by dendritic cell migration - Nature A newly identified bacterial strain (YB328) isolated from the faeces of patients who responded to immune checkpoint blockade therapies can promote antitumour immunity through the activation of tumour-...

www.nature.com/articles/s41...

Today, 1,152 NAS members/Nobel Laureates (as private individuals) sent a letter to Congress regarding the cuts to science being proposed by the Administration, and currently going through the House and Senate Appropriations Committees.

tinyurl.com/5n7y7853

@standupforscience.bsky.social

Controlled Vaccine RCTs (Living List)

If anyone claims vaccines haven’t been properly studied, show them this:

Our living dataset now includes 502 controlled vaccine trials with ~7.2 million trial participants, and it is still growing.

The vast majority of trials reported safety outcomes.

bit.ly/4le8z7D

NIH announces end to funding for animal-only studies - Drug Discovery and Development Drug Discovery and Development covers strategies and technologies related to pharmaceutical research and development and drug formulation.

I’m all for more NAMS, but it has its limits. There are no LLMs or organs-on-a-chip that can model viral pathogenesis, vaccine efficacy, or candidate drugs. We only use animals when there is no other choice.

This will only stop more lifesaving research.
www.drugdiscoverytrends.com/nih-announce...

"Our observations should prompt an essential re-evaluation of the literature concerning astrocyte-neuron mitochondrial transfer" www.biorxiv.org/content/10.1...

Thanks for the hype! 🙏🏼😊

Uridine Uridine is a pyrimidine nucleoside composed of an uracil base and a ribose sugar. In cells, uridine is predominantly present in RNA (as uridine monophosphate, UMP). Uridine can be produced through de ...

Uridine: Trends in Endocrinology & Metabolism www.cell.com/trends/endoc...

a great not-to-miss piece from the @lyssiotislab.bsky.social

The remarkable benefit of exercise was just extended to improved survival after cancer in a randomized trial
@nejm.org
nejm.org/doi/full/10....

The loss data (~$10B) support and N of grants terminated is updated below, but this op-ed by @euanashley.bsky.social hits all the important points @latimes.com @stanfordmedicine.bsky.social
www.latimes.com/opinion/stor...

YouTube video by Amanpour and Company Breakthrough Prize-Winning Biochemist on the Deadly Cost of Funding Cuts | Amanpour and Company

David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏

youtu.be/8YhJM6zxYDw?...

Microbiome metabolism of dietary phytochemicals controls the anticancer activity of PI3K inhibitors Diet can impact anticancer drug activity. A classic example in rodents is a ketogenic diet enhancing PI3K inhibitor activity. Here, we show that phytochemicals and their microbiome derivatives, rather...

Microbiome metabolism of dietary phytochemicals controls the anticancer activity of PI3K inhibitors: Cell www.cell.com/cell/fulltex...

Nation Can't Believe It On Harvard's Side

Good cover @economist.com