In the second work, using an artificial pathway of chromosome condensation, we evaluated a long-standing hypothesis in the field that histone H1 phosphorylation is required for compaction of mitotic or mitotic-like chromosomes - turns out it is not compulsory!

In the first story, we measured histone modifications during highly synchronous mitotic entry and revealed among other things that deacetylation is minor during mitotic chromosome compaction, while it drops precipitously if one prolongs mitosis - for example, with nocodazole.

A time-resolved atlas of histone modifications during mitotic entry Mitotic chromosome formation is essential for faithful chromosome segregation in metazoans. While condensin complexes are critical for the formation of rod-shaped mitotic chromosomes, additional mecha...

Happy to share 2 preprints from my postdoctoral work.

www.biorxiv.org/content/10.1...

- Kudos to @bmccores.bsky.social and blueskyless Bill, Marco, Moonmoon and others!

www.biorxiv.org/content/10.1...

- Kudos to blueskyless Bill, Jim and others!

More about our work below👇