Sikander Hayat

Multi-omic profiling reveals age-related immune dynamics in healthy adults - Nature This multi-omic longitudinal analysis of the healthy human peripheral immune system constructs the Human Immune Health Atlas and assembles data on immune cell composition and state changes w...

What happens to our immune system with aging, reducing vaccine response?
Our memory T cells undergo a dramatic shift resulting in dysregulated B cell antibody production
@alleninstitute.org @nature.com
www.nature.com/articles/s41...

Our human heart failure atlas with 1.8 million nuclei from 195 patients reveals novel cell states, integrates 52 GWAS traits and enables AI Agent driven target discovery. Collaboration between Uniklinik Aachen @rwth.bsky.social & @novonordisk.bsky.social. Poster at @americanheart.bsky.social Nov. 8.

‘Scientists will not be silenced’: thousands protest Trump research cuts Researchers at Stand Up for Science rallies voice defiance against the policies of US President Donald Trump’s administration.

J.P. Flores, a core organizer for today's rallies and a bioinformatics researcher at the University of North Carolina, Chapel Hill, told Nature: “March 7 is the beginning — I don’t necessarily see it as the endpoint.” #StandUpForScience www.nature.com/articles/d41...

Excited to share what I’ve been working on with @tkaraletsos.bsky.social to transform the field of drug discovery with atomistic foundation simulation models!

I could not be more thrilled to be working with this dream team.

achira.ai

The next generation of in situ multi-omics - Nature Methods Spatial-Mux-seq adds to a growing portfolio of innovative spatial omics technologies and enables simultaneous profiling of up to five omic modalities in situ.

The next generation of in situ multi-omics: www.nature.com/articles/s41...

Sikander Hayat on LinkedIn: Thanks Profile Areas of RWTH Aachen University grateful for highlighting… Thanks Profile Areas of RWTH Aachen University grateful for highlighting this. Aachen is in a unique position with Uniklinik RWTH Aachen and RWTH Aachen…

www.linkedin.com/posts/shayat...

Our new decentralized single cell transcriptomics swarm learning approach for cell type annotation!

DEFENDER Trial: Dapagliflozin for Critically Ill Patients with Acute Organ Dysfunction -Implications for clinicians Jolanta Malyszko, the ERAKI Working group of the European Renal Association, Sophie De Seigneux, the ERAKI Working group of the European Renal Association,

Our (European Renal Association AKI Working Group) comment on the DEFENDER RCT: academic.oup.com/ndt/advance-...
SGLT2 inhibitors in critically ill patients are safe but do not reduce mortality or length of stay in the hospital. RCTs testing SGLT2i for AKI prevention and treatment are needed.

Thanks @erictopol.bsky.social for sharing our work!

Encompassing view of spatial and single-cell RNA sequencing renews the role of the microvasculature in human atherosclerosis - Nature Cardiovascular Research Bleckwehl et al. present a spatial transcriptomic map of atherosclerotic plaques across disease stages, revealing cellular recruitment and migration patterns and intercellular communication dynamics a...

Our new paper put today @natureCVR led by @sikandhayat.bsky.social Tore Bleckwehl in collab with NovoNordisk 👇👇 www.nature.com/articles/s44...

Label-free single-cell RNA multiplexing leveraging genetic variability - Nature Communications Here the authors establish and benchmark a single cell RNA multiplexing framework that enables simple, yet robust high-throughput multiplexing leveraging single cell nucleotide polymorphisms of patien...

Our new paper: Label-free single cell RNA-sequencing leveraging genetix variability: www.nature.com/articles/s41... 🔥🔥

Label-free single-cell RNA multiplexing leveraging genetic variability - Nature Communications Here the authors establish and benchmark a single cell RNA multiplexing framework that enables simple, yet robust high-throughput multiplexing leveraging single cell nucleotide polymorphisms of patien...

www.nature.com/articles/s41... Hello Single-cell world!