Dr Emma S Chambers

An exciting programme of talks today. Come and see my poster (17) about menopause as an immune ageing event.

Hormone replacement therapy may help restore immunity in menopausal women https://www.qmul.ac.uk

This #WorldMenopauseDay we're proud to talk about how we supported innovative research into menopause and women's immunity - led by @emmaschambers.bsky.social at the @blizardinstitute.bsky.social

@qmul.bsky.social

https://bit.ly/492IYeG

Hormone replacement therapy may help restore immunity in menopausal women

Happy World Menopause Day. Reminder that as well as the impact of menopause on physical and mental wellbeing. Menopause also seems to be an immune-ageing event www.qmul.ac.uk/media/news/2...

Surprisingly, it is not yet obvious to all researchers and funding agencies that sex and gender matter in research, and should be recorded and addressed properly. So we wrote it authors.elsevier.com/c/1lxSmbah1w...

Hormone replacement therapy helps restore immune function in menopausal women, reducing inflammaging and preserving monocyte function. open-access
onlinelibrary.wiley.com/doi/10.1111/...

Extends what I previously summarized from immune system clocks
erictopol.substack.com/p/new-anti-a...

Age‐Associated Inflammatory Monocytes Are Increased in Menopausal Females and Reversed by Hormone Replacement Therapy Post-menopausal females (> 64 years) have an increase in frequency of inflammatory monocyte populations with defective phagocytosis as compared to pre-menopausal (< 40 years) females. Hormone Replace...

New paper alert #immunosky 🚨
What happens to our immune systems as we get older? What happens after the menopause? Turns out monocytes are actually quite important in their own right!

Check out our paper in Aging Cell now:
onlinelibrary.wiley.com/doi/10.1111/...

I am very grateful to my funders the @vivensa.bsky.social and @bartscharity.bsky.social for funding this research through seed awards. More research is desperately needed to understand the impact of menopause on immunity and I hope more funders consider this as an important research area. #immunosky

This study was an amazing Early Career researcher effort with Roel de Maeyer performing the functional monocyte assays, @oliviabracken.bsky.social performing the bioinformatic analysis, and my lovely lab member Justyna performing the Menopause analysis. I am very grateful for all their hard work.

Importantly the use of Hormone Replacement Therapy (HRT) in menopausal females kept their monocytes looking ‘young’ and they had improved phagocytosis as compared to age matched controls. Highlighting the potential immune benefits of HRT.

In this paper we demonstrate that there is an increase in inflammatory monocytes with altered proteome in post-menopausal females, which is not observed with age in males. Phagocytosis is significantly decreased in post-menopausal as compared to pre-menopausal females.

Age‐Associated Inflammatory Monocytes Are Increased in Menopausal Females and Reversed by Hormone Replacement Therapy Post-menopausal females (> 64 years) have an increase in frequency of inflammatory monocyte populations with defective phagocytosis as compared to pre-menopausal (< 40 years) females. Hormone Replace....

I am so proud to say that our paper is now available at Aging Cell. There is a paucity of data as to how the menopause impacts your immune system, and the aim of this study was to investigate the impact of the menopause on monocyte phenotype and function.
onlinelibrary.wiley.com/doi/10.1111/...

This afternoon I am speaking at @emds2025.bsky.social. Chatting monocytes, ageing and menopause :) Looking forward to an exciting meeting

📣 Abstract submissions for #BSI25 are CLOSING SOON!

Don't miss your chance to share your research — submit today.

🗓️Deadline: Midnight, Weds 3 Sept
🔗Submit here: bit.ly/3UfF6i5

I am recruiting for a postdoc that wants to work on an exciting project on gut macrophages, TGFb signalling, and colon cancer! Please see the link for details - elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

New output from the CELLO Network. Article highlighting how metabolic dysfunction underpins ageing and disease.
Read the full open-access article 👉 link.springer.com/article/10.1...
#Ageing #Metabolism #CellBiology #SystemsBiology

You get to listen to me talk about menopause and immunity :)

GET YOUR APPLICATION IN NOW! Couldn’t recommend this lab more #sciencebffs ♥️

Come join us this fall in Paris

Who's ready for another @thestemvillage.bsky.social Immunology Seminar Series? If you haven't seen these before, we invite LGBTQ+ immunologists to present online to the wider immunology community. If you'd like to present or attend, please drop a mention below #immunosky 🧪 #academicsky

Thanks :). Good question, my collaborators at UCL including @bcellsrosser.bsky.social have been working with samples from transgender individuals who are undergoing gender reaffirming hormone therapy. I am not sure what data they have on monocytes, but it probably won't be functional.

Age-associated inflammatory monocytes are increased in menopausal females and reversed by Hormone Replacement Therapy Biological sex is a crucial, but poorly understood variable in age-related susceptibility to infections and chronic inflammation, inflammageing. Monocytes are important immune cells responsible for in...

If you have wondered how age, sex and even the menopause influences monocyte phenotype and function. Then our new preprint is for you www.biorxiv.org/content/10.1...

Great coverage of the recent JEM paper by @hlpeks.bsky.social, @emmaschambers.bsky.social, @bcellsrosser.bsky.social, Coziana Ciurtin, and colleagues. See the original paper here: rupress.org/jem/article/...

Thank you to @bartscharity.bsky.social who funded my menopause and HRT research. I am super excited for the next dataset on menopause and HRT so keep your eyes peeled 🤓

Finally in middle-aged cis-female donors. Those who were taking Hormone Replacement Therapy (HRT) had similar class switch B cell numbers to younger females. rupress.org/view-large/f...

My favourite bits about the paper come from studying old and young donors. We found that post-menopausal women had similar class switched B cells to men. rupress.org/view-large/f...

Super excited to have contributed to this great paper led by @bcellsrosser.bsky.social @arrdept-ucldom.bsky.social showing that Oestrogen influences B cell class switching. rupress.org/jem/article/...

Her true love is monocytes 😄

Dissecting the role of lysosomal exocytosis in keloid scar pathogenesis at Queen Mary University of London on FindAPhD.com PhD Project - Dissecting the role of lysosomal exocytosis in keloid scar pathogenesis at Queen Mary University of London, listed on FindAPhD.com

We have a new PhD position open in the lab! Interested in the intersection between cell mechanics and protein metabolism in scar formation, then have a look. tinyurl.com/4s7wduhu

Text saying "thank you for teaching me about phagocytosis"

Thank you cards with immune cells drawn on by children

I had a lovely trip to my daughter's class today, to tell them all about our biological army, the immune system, for science week. I got such lovely thank you cards from the class :)

I concur, I am not a fan of voice notes. I only make an exception for @oliviabracken.bsky.social because she is doing amazing analysis for me :)