Dr Emma S Chambers

🧬 How do we move immunosenescence research forward?

Join us in Guildford this May to explore next generation technologies for studying immune ageing.

The event is taking place on 20 and 21 May 2026. Submit an abstract and be part of the discussion! 🔗 https://bit.ly/3YGD7VW

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I am delighted to introduce the 'ImmunoPause' consortium. This is a collection of immunologists who are working on understanding how the immune system changes during the menopause. An important yet understudied research area.
immunopause.my.canva.site#home

At a time when the UK should be capitalising on its global reputation as a great place to do science, this is an enormous own goal. I am so sorry for all those who jobs are going to be impacted.

Delighted to have contributed to this very cool monocyte resolution paper. Do take a look :)

Estrogen influences class-switched memory B cell frequency only in humans with two X chromosomes. From @hlpeks.bsky.social, @emmaschambers.bsky.social, @bcellsrosser.bsky.social, Ciurtin et al. 👉 rupress.org/jem/article/...

📘 In 2025: The Year in Experimental Medicine rupress.org/jem/collecti...

How do we better measure and target immune ageing?

Registrations are now open for 'New technologies to advance immunosenescence research'. Join us on 20 and 21 May 2026 in Surrey to hear from experts in immune ageing and next generation technologies 🔬

https://bit.ly/3YGD7VW

PhD Projects 2026: QMUL Centre for Predictive in vitro Models The Centre for Predictive in vitro Models (CPM) represents multidisciplinary research focusing on the development and use of predictive in vitro models at Queen Mary University of London. This incorpo...

Interested in developing an asthma organ-on-a-chip model? Then your luck is in! As I have a funded PhD as part of the COaCT PhD programme www.cpm.qmul.ac.uk/cdt/projects...

Research Highlight of the Year Arthritis UK Research Highlight of the Year: celebrate the outstanding work that’s made a real impact over the past year.

Loving #BSI25, especially @ciurtinlab.bsky.social and @emmaschambers.bsky.social highlighting our paper in @jem.org is one of #ArthritisUK top research output of ‘25! If you have 5 minutes, give us a vote (number 5) below, sex differences in the immune system:

www.arthritis-uk.org/our-research...

Great to see a slide in the immunosenescence session advertising our exciting meeting next year #BSI25

I am off to the @britsocimm.bsky.social Congress this week. I will be speaking about menopause and monocytes in the sex differences nsession on Tuesday and chairing the skin session on Thursday. Looking forward to seeing all my immunology friends :) #BSI25

An exciting programme of talks today. Come and see my poster (17) about menopause as an immune ageing event.

Hormone replacement therapy may help restore immunity in menopausal women https://www.qmul.ac.uk

This #WorldMenopauseDay we're proud to talk about how we supported innovative research into menopause and women's immunity - led by @emmaschambers.bsky.social at the @blizardinstitute.bsky.social

@qmul.bsky.social

https://bit.ly/492IYeG

Hormone replacement therapy may help restore immunity in menopausal women

Happy World Menopause Day. Reminder that as well as the impact of menopause on physical and mental wellbeing. Menopause also seems to be an immune-ageing event www.qmul.ac.uk/media/news/2...

Surprisingly, it is not yet obvious to all researchers and funding agencies that sex and gender matter in research, and should be recorded and addressed properly. So we wrote it authors.elsevier.com/c/1lxSmbah1w...

Hormone replacement therapy helps restore immune function in menopausal women, reducing inflammaging and preserving monocyte function. open-access
onlinelibrary.wiley.com/doi/10.1111/...

Extends what I previously summarized from immune system clocks
erictopol.substack.com/p/new-anti-a...

Age‐Associated Inflammatory Monocytes Are Increased in Menopausal Females and Reversed by Hormone Replacement Therapy Post-menopausal females (> 64 years) have an increase in frequency of inflammatory monocyte populations with defective phagocytosis as compared to pre-menopausal (< 40 years) females. Hormone Replace...

New paper alert #immunosky 🚨
What happens to our immune systems as we get older? What happens after the menopause? Turns out monocytes are actually quite important in their own right!

Check out our paper in Aging Cell now:
onlinelibrary.wiley.com/doi/10.1111/...

I am very grateful to my funders the @vivensa.bsky.social and @bartscharity.bsky.social for funding this research through seed awards. More research is desperately needed to understand the impact of menopause on immunity and I hope more funders consider this as an important research area. #immunosky

This study was an amazing Early Career researcher effort with Roel de Maeyer performing the functional monocyte assays, @oliviabracken.bsky.social performing the bioinformatic analysis, and my lovely lab member Justyna performing the Menopause analysis. I am very grateful for all their hard work.

Importantly the use of Hormone Replacement Therapy (HRT) in menopausal females kept their monocytes looking ‘young’ and they had improved phagocytosis as compared to age matched controls. Highlighting the potential immune benefits of HRT.

In this paper we demonstrate that there is an increase in inflammatory monocytes with altered proteome in post-menopausal females, which is not observed with age in males. Phagocytosis is significantly decreased in post-menopausal as compared to pre-menopausal females.

Age‐Associated Inflammatory Monocytes Are Increased in Menopausal Females and Reversed by Hormone Replacement Therapy Post-menopausal females (> 64 years) have an increase in frequency of inflammatory monocyte populations with defective phagocytosis as compared to pre-menopausal (< 40 years) females. Hormone Replace....

I am so proud to say that our paper is now available at Aging Cell. There is a paucity of data as to how the menopause impacts your immune system, and the aim of this study was to investigate the impact of the menopause on monocyte phenotype and function.
onlinelibrary.wiley.com/doi/10.1111/...

This afternoon I am speaking at @emds2025.bsky.social. Chatting monocytes, ageing and menopause :) Looking forward to an exciting meeting

📣 Abstract submissions for #BSI25 are CLOSING SOON!

Don't miss your chance to share your research — submit today.

🗓️Deadline: Midnight, Weds 3 Sept
🔗Submit here: bit.ly/3UfF6i5

I am recruiting for a postdoc that wants to work on an exciting project on gut macrophages, TGFb signalling, and colon cancer! Please see the link for details - elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

New output from the CELLO Network. Article highlighting how metabolic dysfunction underpins ageing and disease.
Read the full open-access article 👉 link.springer.com/article/10.1...
#Ageing #Metabolism #CellBiology #SystemsBiology

You get to listen to me talk about menopause and immunity :)

GET YOUR APPLICATION IN NOW! Couldn’t recommend this lab more #sciencebffs ♥️

Come join us this fall in Paris

Who's ready for another @thestemvillage.bsky.social Immunology Seminar Series? If you haven't seen these before, we invite LGBTQ+ immunologists to present online to the wider immunology community. If you'd like to present or attend, please drop a mention below #immunosky 🧪 #academicsky

Thanks :). Good question, my collaborators at UCL including @bcellsrosser.bsky.social have been working with samples from transgender individuals who are undergoing gender reaffirming hormone therapy. I am not sure what data they have on monocytes, but it probably won't be functional.