Prof Fergal O’Brien

Well done to Juan Carlos Palomeque and the whole interdisciplinary team involved in the study. Grateful to all funders particularly @researchireland.ie @AMBERCentre.bsky.social who funded Juan Carlos's PhD thesis carried out under the supervision of @sbrowne4.bsky.social Cathal Kearney & I.

Scaffold-mediated miRNA-155 inhibition promotes regenerative macrophage polarisation leading to anti-inflammatory, angiogenic and neurogenic responses for wound healing Chronic wounds represent a significant clinical challenge due to persistent inflammation and impaired nerve regeneration that delay healing. Conventio…

Our latest @tissueengdublin.bsky.social paper in Bioactive Materials on a new #bioactive #biomaterial for #woundhealing showing how scaffold-mediated miRNA-155 inhibition promotes regenerative macrophage polarisation to direct chronic wound healing.
www.sciencedirect.com/science/arti...

A multidisciplinary team effort led by @taramcguire.bsky.social as part of her @researchireland.ie @ambercentre.bsky.social & IRFU Charitable Trust funded PhD. Thanks to everyone involved particularly our #PPI advisory panel of clinicians & injured players living with spinal cord injury.

Development of a PTEN-siRNA activated scaffold to promote axonal regrowth following spinal cord injury

Our latest publication in Bioactive Materials showing how scaffold based #genedelivery can be applied to #spinalcord with a PTEN-siRNA activated scaffold promoting axonal regrowth
www.sciencedirect.com/science/arti...

Lesion-targeted, severity-responsive nanoparticle delivery for RNA therapy in osteoarthritis - Nature Nanotechnology Matrix-INverse Targeting (MINT) nanoparticles harness cartilage changes to deliver RNA therapies, reducing degeneration and pain in osteoarthritis.

Got a minute to spare? Why not give TERG's latest piece in #NatureNanotechnology a read!
www.nature.com/articles/s41...
@fjobrien.bsky.social
@rcsi.bsky.social
@rcsi-research.bsky.social

Delighted to see this publication from our @ambercentre.bsky.social collaboration with Integra LifeSciences which shows how laser treatment of natural polymers can be used to tailor site-specific degradation, controlled vascularization & enhanced tissue repair. doi.org/10.1016/j.ac...

Lovely weekend at @bini-irl.bsky.social conference. Superb plenary talks by Molly Stevens & Haughton Lecturer Michael Walsh. Well done to @tissueengdublin.bsky.social team for excellent presentations including prize winners Aamena Mejevdiwala, Eavan Pakenham & Joshua Pepper! #BinI2026 #TERGonTour

Lesion-targeted, severity-responsive nanoparticle delivery for RNA therapy in osteoarthritis - Nature Nanotechnology Matrix-INverse Targeting (MINT) nanoparticles harness cartilage changes to deliver RNA therapies, reducing degeneration and pain in osteoarthritis.

RNA therapeutics may have potential to treat complex conditions such as #osteoarthritis. In this article in Nature Nanotechnology,
Claudio Intini & I descibe the prospects in the field & highlight a recent article by Dewani et al which shows the potential of this area
www.nature.com/articles/s41...

Great to have Prof Anthony Windebank in @rcsi.bsky.social today to discuss our IRFU Charitable Trust @ambercentre.bsky.social @tissueengdublin.bsky.social collaboration with Mayo Clinic on biomaterials for spinal cord injury.

Well done to @researchireland.ie for developing this ARC hub program. These hubs will be unique & really exciting enablers of innovation in Ireland. Very pleased to be involved both from @rcsi.bsky.social institutional and @tissueengdublin.bsky.social & @ambercentre.bsky.social PI perspective.

Congratulations to Matthew and thanks to Fabio Quondamatteo and Ed Sander for taking the time to examine Matthew's PhD thesis. We are grateful to the @researchireland.ie @ambercentre.bsky.social for funding this project.

Tomorrow! Join us tomorrow November 13th in the old Science Gallery in @tcddublin.bsky.social from 6-8pm to see the animated short 'Something's Missing' from TERG and 'Quantum Quest' from TCD with an introduction from @fjobrien.bsky.social

Lovely evening at the @RCSI School of Postgraduate Studies Awards & Black Jacket ceremony for record intake of >150 new doctoral students. Delighted to welcome in particular our new group of @tissueengdublin.bsky.social PhD students!

Really exciting times ahead and look forward to welcoming everyone to RCSI to experience our new public engagement space! #Humanarium

During my visit to China, I also got back to beautiful Suzhou to meet research MSc students in our International College of Pharmaceutical Innovation partnership program between @rcsi.bsky.social and Soochow University.

Just back from Wuhan and TERMIS Asia Pacific conference with our @tissueengdublin.bsky.social team #TERGonTour

Looking forward to opening the #MyHealthRCSI ‘Rethinking Asthma’ event this evening. More information in today’s Irish Times.

New thinking on asthma management may be a game-changer
www.irishtimes.com/health/your-...

Great to have our latest paper published in Biomaterials on tissue engineering strategies for peridontal & endodontic regeneration. A really nice collaboration between @tissueengdublin.bsky.social & our dental colleagues. authors.elsevier.com/sd/article/S...

Irish universities should have no tariffs on talent Decades of reform and cultural change have made our colleges European leaders in gender equality and diversity – but the work of protecting rights continues

In today’s @irishtimes.com, RCSI’s Head of EDI, Liz Hughes explores the progress made by Irish HEIs in equality, diversity and inclusion and calls for a wider protection of human rights: www.irishtimes.com/ireland/educ...

A great first day at the International Congress on Biomaterials for Wound Healing for the TERG team yesterday!
#ICBWH2025
@fjobrien.bsky.social
@markodobricic.bsky.social
@rcsi.bsky.social

The contributions from our #PPI panel including Ciaran McCarthy were essential to this research. We are grateful to the IRFU Charitable Trust & @researchireland.ie for funding this project. @rcsi-research.bsky.social

advanced.onlinelibrary.wiley.com/doi/full/10....

Great example of research that would not have occurred without the unique interdisciplinary environment of @ambercentre.bsky.social A real team effort between @tissueengdublin.bsky.social researchers led by research fellow Ian Woods and 2D materials scientists from Prof Valeria Nicolosi’s lab.

Publication in Advanced Science from Dr Ian Woods on the development of spatially-organised electroconductive neurotrophic scaffolds for repair of neurotrauma! Facilitated by joint funding from the Research Ireland AMBER Centre and the IRFU Charitable Trust, read the press release and paper below!

RCSI researchers develop 3D printed implant to help repair spinal cord injuries A research team at RCSI has developed a 3D printed implant to deliver electrical stimulation to injured areas of the spinal cord. More ...

An implant developed by RCSI and @ambercentre.bsky.social researchers has been shown to deliver electrical stimulation to injured areas of the spinal cord.

The study, in partnership with the IFRU-CT, offers a potential new route to repair nerve damage.

➡️ www.rcsi.com/dublin/news-...

#RCSIdiscover

Great to see this published. Well done to Claudio Intini, Michael Joyce and everyone involved in the project - in particular Pieter Brama & his team in UCD School of Veterinary Medicine. Latest output from our @erc.europa.eu funded #ReCaP project. @rcsi-research.bsky.social

Delighted to welcome @garryduffy.bsky.social back to RCSI & as new Prof. of Anatomy in Dept. of Anatomy & Regen Med.
He brings a wealth of research experience in advanced biomaterials and medical technologies and his work is a great addition to @tissueengdublin.bsky.social. Exciting times ahead.

A smiling graduate in academic dress holds a large ornate picture frame, through which five other graduates, also in caps and gowns, are visible in the background. The group is outdoors in a leafy green park.

Three graduates in black gowns and mortarboards stand smiling outside the RCSI building. Each holds a red diploma scroll and wears a green and red academic hood.

A graduate poses indoors in her gown and cap, holding a red diploma scroll, surrounded by her smiling family—two adults, two older children, and a younger girl who also holds the scroll.

Congratulations to the 344 new doctors who celebrated at our #RCSIConferring yesterday 🎓

RCSI’s School of Medicine class of 2025 came together with friends and family to celebrate their achievements.

Read more about the conferring ceremony here: tinyurl.com/3bbbn3tn

Congratulations to Professor Andreas Heise, RCSI Department of Chemistry and collaborator Professor Matthew Gibson on their success in this EPSRC-Research Ireland programme.

Their research will investigate the prevention of ice formation where sub-zero temperatures are present.

#RCSIdiscover

Congratulations to our latest PhD graduates: Liam Leahy, Stefanie Croghan, Tara McGuire and Michael Joyce (in absentia) who graduated yesterday! 🥳
Congratulations to supervisors @fjobrien.bsky.social, Adrian Dervan and Niall Davis!

Biomimetic Scaffolds Enhance iPSC Astrocyte Progenitor Angiogenic, Immunomodulatory, and Neurotrophic Capacity in a Stiffness and Matrix‐Dependent Manner for Spinal Cord Repair Applications Through tuning biomimetic scaffold stiffness and matrix composition the reparative capacity of astrocyte progenitors is enhanced. Soft, collagen-IV/fibronectin-functionalized scaffolds promote progen....

'Biomimetic Scaffolds Enhance iPSC Astrocyte Progenitor Angiogenic, Immunomodulatory, and Neurotrophic Capacity in a Stiffness and Matrix-Dependent Manner for Spinal Cord Repair Applications' is online in Advanced Healthcare Materials!
Read it: advanced.onlinelibrary.wiley.com/doi/10.1002/...