Shalini Agarwal's Avatar

Shalini Agarwal

@shaliniagarwal.bsky.social

Researcher @MRC PPU studying mitochondrial quality control. Interested in Mitophagy and ISR in ALS/MND #mitochondria #ISR #Pink1 #kinase #ALS

105 Followers  |  159 Following  |  3 Posts  |  Joined: 11.05.2025  |  1.6526

Latest posts by shaliniagarwal.bsky.social on Bluesky

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Happy to have received a poster prize at the UK #Autophagy and #Proteostasis Conference!
Grateful to receive it from one of the leading figures in the field of proteostasis (@annebertolotti.bsky.social). A special thank you to the organisers for such a vibrant and insightful meeting!!

05.06.2025 21:28 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Michael Lazarouย and I will be chairing the 11th International Symposium on Autophagy (ISA) in Australia from 16-20 Nov 2025!
๐Ÿ“ย Location:ย Lorne, Victoria, Australia
๐ŸŒย Register now:ย www.isa11.org
Join us forย five inspiring days of cutting-edge autophagy research and networking opportunities.

31.05.2025 03:58 โ€” ๐Ÿ‘ 21    ๐Ÿ” 12    ๐Ÿ’ฌ 3    ๐Ÿ“Œ 0
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The bridge-like lipid transport protein VPS13C/PARK23 mediates ERโ€“lysosome contacts following lysosome damage Nature Cell Biology - Wang et al. show the recruitment of the lipid channel protein VPS13C and formation of VPS13C-dependent contacts between endoplasmic reticulum and lysosomes after lysosomal...

"The bridge-like lipid transport protein VPS13C/PARK23 mediates ERโ€“lysosome contacts following lysosome damage" out now in Nature Cell Biology
rdcu.be/ehbaL

10.04.2025 14:17 โ€” ๐Ÿ‘ 50    ๐Ÿ” 25    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
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Kinome screening identifies integrated stress response kinase EIF2AK1/HRI as a negative regulator of PINK1 mitophagy signaling Loss-of-function mutations in the PINK1 kinase lead to early-onset Parkinsonโ€™s disease (PD). PINK1 is activated by mitochondrial damage to phosphorylate ubiquitin and Parkin, triggering mitophagy. PIN...

Kinome screening identifies integrated stress response kinase EIF2AK1/HRI as a negative regulator of PINK1 mitophagy signaling
pmc.ncbi.nlm.nih.gov/articles/PMC...

11.05.2025 11:48 โ€” ๐Ÿ‘ 6    ๐Ÿ” 3    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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MRC PPU on X: "MRCPPU researchers discover new drug target for #Parkinsonโ€™s disease https://t.co/b2bvyvahXN https://t.co/6NMtKWpXct" / X MRCPPU researchers discover new drug target for #Parkinsonโ€™s disease https://t.co/b2bvyvahXN https://t.co/6NMtKWpXct

x.com/mrcppu/statu...

13.05.2025 14:23 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Kinome screening identifies integrated stress response kinase EIF2AK1/HRI as a negative regulator of PINK1 mitophagy signaling EIF2AK1/HRI kinase negatively regulates PINK1 mitophagy.

Excited that our work revealing the regulation of PINK1 by ISR pathway, is out now! A new regulatory axis in mitophagy and mitochondrial quality control #mitophagy #Pink1 #mitochondria #ISR #Neurodegeneration
@mrcppu.bsky.social

www.science.org/doi/10.1126/...

12.05.2025 06:26 โ€” ๐Ÿ‘ 10    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

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