Alessandra Carbone

PRESCOTT: a population aware, epistatic, and structural model accurately predicts missense effects - Genome Biology Predicting the functional impact of point mutations is a critical challenge in genomics. PRESCOTT reconstructs complete mutational landscapes, identifies mutation-sensitive regions, and categorizes mi...

PRESCOTT online in Genome Biology! see how it works on differentiating mutational effects across isoforms, on unique genetic heritage, recessive and dominant inheritance modes, gain-of-function mutations at link.springer.com/article/10.1....
Work done with M.Tekpinar T.Henry L.David

06.05.2025 20:09 — 👍 0    🔁 0    💬 0    📌 0

Designing a functional switch? We recoded a function of Chlamydomonas reinhardtii thioredoxin type-h into a photosynthetic type-f by switching selectivity determinants. Soon out in Frontiers in Plant Science: lnkd.in/emVPNHHa
with Julien Henri, Stephane Lemaire, Gianluca Lombardi and Andrea Mancini.

20.02.2025 07:14 — 👍 1    🔁 0    💬 0    📌 0

Diversifying disorders by distinguishing intrinsic and soft disorders, improves our understanding of proteins. See our new preprint on "LoRA-DR-suite: adapted embeddings predict intrinsic and soft disorder from protein sequences" - lnkd.in/esSD3qxq work done with Beatriz Seoane and Gianluca Lombardi

08.02.2025 19:49 — 👍 1    🔁 0    💬 0    📌 0

Postdoc position on Al-Driven Discovery of Next-Gen Antibiotics. Join my team! Please, forward it. hashtag#AI hashtag#MachineLearningandAI hashtag#Artificialintelligence hashtag#MachineLearning hashtag#protein

01.02.2025 22:15 — 👍 3    🔁 0    💬 0    📌 0