The Charles Sawyers Lab

#KnowAboutMyScience: Tumors are complex ecosystems - not just cancer cells, but networks of interacting cell types. I study these relationships to uncover how cancer hijacks biology and help develop better therapies. #CareerAdvice: Challenge yourself by changing environments- new institutions, cities, or countries. It's one of the best ways to grow as a scientist. #BecomingAScientist: I once dreamed of being an investigative journalist. Now I chase mysteries at the cellular level, just as fascinating, only under a microscope. #FunFuct: From sports to theater, my childhood was packed with activities. Each taught me something different, but together they shaped my creativity, discipline, and persistence- qualities I catty into science. Agnieszka Chryplewicz, PhD Sawyers Lab National Postdoc Appreciation Week September 2025

Meet #MSKPostdoc Agnieszka Chryplewicz (@aga-chryplewicz.bsky.social) from the @sawyerslabmskcc.bsky.social! She studies how tumor-derived factors in prostate cancer shape immune responses to promote tumor growth and limit treatment success.
#NPAW2025 🇵🇱

30.09.2025 18:26 — 👍 4    🔁 2    💬 0    📌 0

NPAW 2025 photo contest winners Penni for our thoughts - Megan E. Kelley (Sfeir Lab) May your generating station for science never stop, and may it kiss the skyline with a touch of beauty - Zhendong Cao (Sawyers Lab) Who needs WiFi when the universe is streaming live above your tent? - Manendra Lankadasari (Jones Lab)

While our judges deliberate the top 3 winners of MSK Postdoc Slam, let’s celebrate our #NPAW2025 📸 contest champs! 🎉
🥇 @meganekelley.bsky.social – @agnelsfeir.bsky.social lab
🥈 Zhendong Cao – @sawyerslabmskcc.bsky.social
🥉 Manendra Lankadasari – Jones lab
Congrats to our amazing #MSKPostdocs! 👏📷

15.09.2025 20:44 — 👍 9    🔁 3    💬 1    📌 1

Congratulations to Zhendong, Megan & Manendra!!

15.09.2025 20:56 — 👍 1    🔁 0    💬 0    📌 0

ERG-driven prostate cancer initiation is cell-context dependent and requires KMT2A and DOT1L Nature Genetics - Lineage tracing in mice identifies a subpopulation of basal cells that express Tmprss2 and Nkx3 as the origin of ERG-driven prostate cancer. Upon expansion, these cells show an...

OUT NOW: ERG-driven prostate cancer initiation is cell-context dependent and requires KMT2A and DOT1L rdcu.be/eEVKR @mskcancercenter.bsky.social @natureportfolio.nature.com #SawyersLabMSKCC

08.09.2025 15:38 — 👍 6    🔁 4    💬 0    📌 0

PNAS Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Just out: BRCA2 reversion mutation–independent resistance to PARP inhibition through impaired DNA prereplication complex function | PNAS www.pnas.org/doi/10.1073/... @mskcancercenter.bsky.social @kyriepappas.bsky.social #SawyersLabMSKCC

10.06.2025 15:53 — 👍 6    🔁 5    💬 0    📌 1

Uncoupling of Akt and mTOR signaling drives resistance to Akt inhibition in PTEN loss prostate cancers Restoration of downstream mTOR signaling causes resistance to combined Akt and androgen receptor blockade in prostate cancer.

OUT NOW: Uncoupling of Akt and mTOR signaling drives resistance to Akt inhibition in PTEN loss prostate cancers | Science Advances www.science.org/doi/10.1126/... #SawyersLab #MSKCC @mskcancercenter.bsky.social

20.02.2025 20:39 — 👍 9    🔁 2    💬 0    📌 0