Agnel Sfeir

Proteome-wide in silico screening for human protein-protein interactions Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...

Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp

#BecomingAScientist: Being a scientist is one of the most exciting and engaging careers that exists. It demands the work of a community of researchers to make meaningful progress and thrives on a diversity of backgrounds and experiences to solve some of the world's most complex and interesting problems. The opportunity to join this global community and contribute to our shared mission of understanding our world and benefiting humanity is a gift. #CareerAdvice: Own your missteps and keep moving forward. Set reasonable expectations for yourself and give yourself grace when you need it. And we work better together, so accept help when you can. Megan E. Kelley, PhD Sfeir Lab National Postdoc Appreciation Week September 2025

Meet #MSKPostdoc Megan E. Kelley (@meganekelley.bsky.social) in the @agnelsfeir.bsky.social Lab, where she studies error-prone DNA 🧬 damage repair in the context of cancer and drug resistance.
👏 Congrats to Megan on receiving both the NCI F32 and MSK Society Scholar awards!
#NPAW2025

Congrats Maria! very well deserved... @mskcancercenter.bsky.social @mskeducation.bsky.social

🎉 Congratulations to our 10 MSK Postdoc Slam finalists! 👏 You were all fantastic and it was truly inspiring to learn about the incredible and diverse work happening at @mskcancercenter.bsky.social. Our #MSKPostdocs gave the judges a real challenge… choosing winners was no easy task! 🤗 #NPAW2025

NPAW 2025 photo contest winners Penni for our thoughts - Megan E. Kelley (Sfeir Lab) May your generating station for science never stop, and may it kiss the skyline with a touch of beauty - Zhendong Cao (Sawyers Lab) Who needs WiFi when the universe is streaming live above your tent? - Manendra Lankadasari (Jones Lab)

While our judges deliberate the top 3 winners of MSK Postdoc Slam, let’s celebrate our #NPAW2025 📸 contest champs! 🎉
🥇 @meganekelley.bsky.social – @agnelsfeir.bsky.social lab
🥈 Zhendong Cao – @sawyerslabmskcc.bsky.social
🥉 Manendra Lankadasari – Jones lab
Congrats to our amazing #MSKPostdocs! 👏📷

Megan Elizabeth Kelley, PhD Sfeir Lab/ Molecular Biology Losing our edge: Combating drug resistance in cancer

It’s SHOW TIME! 🎤 Kicking off the MSK Postdoc Slam is @meganekelley.bsky.social from the @agnelsfeir.bsky.social lab, diving into how error-prone DNA repair fuels drug resistance in cancer 🧬💊

Gerstner Sloan Kettering Graduate School of Biomedical Sciences The Gerstner Sloan Kettering Graduate School of Biomedical Sciences offers the next generation of basic scientists a program to study the biological sciences through the lens of cancer

Now accepting applications for our 2026 Cancer Biology & Cancer Engineering programs. Aspiring scientists & engineers will solve fundamental problems in biology & conduct research & develop technology that will help understand, diagnose & treat cancer.
bit.ly/3WUiuo1

🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀

Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.

Sign up. Stay informed. Join the movement: www.nycures.org/

Postdoctoral Research Associate in the Blackford Group A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.

Please get in touch with your CV if you are interested; closing date: 27th June 2025.

More details here: candidate.hr-manager.net/ApplicationI...

Congrats!! Not a bad way to start your own lab 😜

Excited to share our latest from my postdoc at @mskcancercenter.bsky.social in the Sfeir Lab, in collaboration with the Simon Powell Lab! We uncovered a novel genome repair mechanism in human cells: RNA-templated DNA double-strand break repair (RT-DSBR). (1/5)

YouTube video by LastWeekTonight RFK Jr. & HHS: Last Week Tonight with John Oliver (HBO)

Here is the link to the Last Week Tonight with John Oliver about RFK, Jr, public health, and HHS (including NIH)

www.youtube.com/watch?v=8H34...

Opinion | Science Suffers With Trump’s Funding Freeze America’s scientific enterprise demands reliable stewardship, not destabilizing political intervention.

My father-in-law, Jack Strominger, and I wrote a letter to the @wsj.com editor about the current threats to science due to Trump's funding freeze. Please repost! www.wsj.com/opinion/scie...

Harvard University Harvard University is devoted to excellence in teaching, learning, and research, and to developing leaders who make a difference globally.

Take a look at the harvard web site...We have our break-throughs and next generation drugs on full display! Come take a look at the new wonders of medicine! So proud to be a part of it!!! Harvard.edu

🚨 Join us for the @faseborg.bsky.social
Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!

Nobel laureate: I owe America my success. Today, its scientific future is in danger | CNN Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...

Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.”
A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...

📢#BGFP25 GRANTS AVAILABLE & TALK DEADLINE EXTENDED!

💰We are excited to announce we have at least 10 reg support grants ready to award to those submitting abstracts!

🧑‍💼Our short talk submission deadline has been extended and will now close on 01 April.

Submit your abstract HERE: bit.ly/3AnsVZF

Harvey Society lecture tonight features Eric Olson. Come listen to an absolute giant in muscle biology! Bonus roast/ appreciation by me and Mary Baylies!

harveysociety.org/lectures/abs...

Scientists have just cured pancreatic cancer in some patients with personalized mRNA vaccines. Pancreatic cancer. And this Trump administration wants to throw it all away.

They’re throwing away a cure for cancer.

Fu et al, Engineering mtDNA deletions by reconstituting end joining in human mitochondria https://www.cell.com/cell/abstract/S0092-8674(25)00194-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867425001941%3Fshowall%3Dtrue

A new collection of papers on #mitochondrialdiseases is ready: biomed.news/bims-mitdis/...
Congratulations to all authors!

@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social

Highlight: Engineering mtDNA deletions by reconstituting end joining in human mitochondria

Thanks Mike. And yes, super cool that ur work ( and others) on mycobacterium is the catalyst for our cross kingdom approach.

Congrats Agnel! As a side note, also an example of how studying diverse systems of DNA repair yields unexpected benefits across domains of life, in this case the NHEJ system of mycobacteria, the first prokaryotic NHEJ system to be characterized: www.nature.com/articles/nsm...

Thanks, Ronan and the entire team... this publication would not be possible without SAIL.

This publication is deeply meaningful to us, as Ignas tragically passed away last year from a sudden and aggressive cancer. Proud that his incredible scientific legacy lives on through this work. We will never forget him, and it has only strengthened our dedication to the work we do at MSKCC.

NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

No matter what Rocket Man says, the NIH offers a strong return on investment www.forbes.com/sites/michae...

Postdoc Night Science NYC! Next session is Friday 4-6pm at MSK, to learn and practice the creative scientific process! The topic this time is the import/export of ideas. Yael David join us too! @davidlabmsk.bsky.social
Limited spots: docs.google.com/forms/d/12bB... @kelseymonson.bsky.social

The work was led by @yi-fu.bsky.social , Max Land, and Tamar Kavlashvili. This manuscript is am @mskcancercenter.bsky.social family affair. Thanks to the contributions from the labs @danapeer.bsky.social al and @caleblareau.bsky.social, Ed Reznik, Craig Thompson, and the incredible help of SAIL.

Engineering mtDNA deletions by reconstituting end joining in human mitochondria Recent breakthroughs in the genetic manipulation of mitochondrial DNA (mtDNA) have enabled precise base substitutions and the efficient elimination of…

Combining bacterial end joining with programmable nucleases, we induced mtDNA deletions in human cells at varying heteroplasmy and examined their metabolic and cellular effects. Simple tool to apply across any cell type and engineer pathogenic mtDNA deletions. www.sciencedirect.com/science/arti...

A subcellular map of translational machinery composition and regulation at the single-molecule level Millions of ribosomes are packed within mammalian cells, yet we lack tools to visualize them in toto and characterize their subcellular composition. In this study, we present ribosome expansion micros...

Exciting new work from Barna Lab @stanfordmedicine.bsky.social

www.science.org/doi/10.1126/...

Structural mechanism of LINE-1 target-primed reverse transcription Long interspersed element-1 (LINE-1) retrotransposons are the only active autonomous transposable elements in humans. They propagate by reverse transcribing their mRNA into new genomic locations by a ...

Excited to share our latest work, led by the incredible @automnenine.bsky.social (now an Ass. Prof. at Princeton)! We uncover key insights into the retrotransposition mechanisms of LINE-1 ORF2p, the enzyme responsible for writing a significant portion of our genome.
www.science.org/doi/10.1126/...