Grant Rowe

There are two types of people in academic medicine - those who are there because it is their lifetime calling, others who are there to take home a paycheck.
The fundamental problem is that those there for the paycheck hold all of the power.

The ISEH just launched a brand new website! Check it out and join our society today to network with your colleagues and keep abreast of the latest advances in basic and translational experimental hematology research!

iseh.org

I really enjoyed reading this paper. Use of basic culture-based and in vivo differentiation models with targeted application of -omics.

Remembering James Till, 1931-2025 It has been 64 years since the publication of the classic 1961 Till & McCulloch paper that described spleen colonies in lethally irradiated mice following a bone marrow transplant [1]. On May 18, 2024...

Excellent obituary summarizing the contributions of Dr Till's foundational work in defining the hematopoietic hierarchy in Experimental Hematology
@isehsociety.bsky.social
www.exphem.org/article/S030...

Cell-extrinsic factors contribute toward myeloid-biased expansion in Tet2-mutant clonal hematopoiesis Hematopoietic stem cells (HSCs) acquire somatic mutations throughout life, with the frequency of mutational incidence increasing with age [1]. Occasionally, certain mutations confer a fitness advantag...

Here is the first in a planned series of article commentaries in Experimental Hematology
@isehsociety.bsky.social - thanks to @challenlab.bsky.social and @lindemileslab.bsky.social!
www.exphem.org/article/S030...

The developmental clock: where art and science meet Elaine DzierzakDrs. Elaine Dzierzak and Anna Bigas recently edited a special collection for Experimental Hematology entitled “Making blood: mechanisms of early hematopoietic development” [1]. This is ...

What an interesting read...did you know that Developmental Hematopoiesis pioneer Elaine Dzierzak was also an artist? Read on to learn more in a recent issue of Experimental Hematology!

The developmental clock: where art and science meet - Experimental Hematology www.exphem.org/article/S030...

Absolute pleasure to chat with those two brilliant scientists! Do yourself a favour and have a look at their preprints! #hemesky

I failed a billing audit this week and it was like I had left the new coversheets off of my TPS reports #medicaladministrativestate

We are very proud of this new content spearheaded by @alessandrodonada.bsky.social!
Our lab is very grateful to Alessandro for highlighting our two recent preprints.

Methodological Considerations on How to Identify Human Hematopoietic Stem Cells The hematopoietic system is highly regenerative and is organized hierarchically with hematopoietic stem cells (HSCs) sitting at the apex. Despite being some of the most widely studied stem cells, ques...

@isehsociety.bsky.social community: if you’re interested in HSC research in humans then this is a must read from leaders in the field. www.exphem.org/article/S030...

Uridine Metabolism as a Targetable Metabolic Achilles' Heel for chemo-resistant B-ALL https://www.biorxiv.org/content/10.1101/2025.01.27.635108v1

Path of differentiation defines human macrophage identity Macrophages play central roles in immunity, wound healing, and homeostasis - a functional diversity that is underpinned by varying developmental origins. The impact of ontogeny on properties of human ...

Second preprint of the day:
www.biorxiv.org/content/10.1...

Look at that, a trifecta of ISEH member preprints @bloodandtime.bsky.social @dorrancelab.bsky.social @kentlab.bsky.social
biorxiv.org/content/earl...
biorxiv.org/content/earl...
biorxiv.org/content/earl...

Dynamic activity of Erg promotes aging of the hematopoietic system Hematopoiesis changes to adapt to the physiology of development and aging. Temporal changes in hematopoiesis parallel age-dependent incidences of blood diseases. Several heterochronic regulators of he...

Here's a new preprint from our group. This manuscript continues our efforts to understand the mechanisms that distinguish fetal/juvenile versus adult hematopoiesis to better understand pediatric blood diseases.
www.biorxiv.org/content/10.1...

Early morning swimming in the cold at Stanford.

I really enjoy putting those together, please if you see your preprint in this list do not hesitate to get in touch!
#hemesky 🔬🩸

Blood across our lifetimes: A dynamic story - Boston Children's Answers A new atlas reveals how blood stem cells ramp up and pivot their activities to match our needs across our lifespan.

answers.childrenshospital.org/blood-atlas/

Winter break is good for catching up on some reading 😉! #ISEH #SimplyBlood @isehsociety.bsky.social

Failure of metabolic checkpoint control during late-stage granulopoiesis drives neutropenia in reticular dysgenesis Key PointsActive metabolic checkpoints respond to AK2 deficiency by decreasing anabolic pathways to maintain nutrient homeostasis and proliferation.When me

Interesting mechanistic work on reticular dysgenesis from my former colleague Dr Weinacht @bloodjournal.bsky.social
ashpublications.org/blood/articl...

Our latest work is now available to read on bioRxiv! Very proud of this and its potential implications for patients with acute myeloid leukemia 🩸 🧪 🔬💊 **eIF4A-mediated translation initiation as an AML cell vulnerability that can be co-targeted with BCL-2 inhibition** www.biorxiv.org/content/10.1...

speedball.

Thanks, friend. Hope you are well.

We are very proud of this new resource for the community. Thanks @alessandrodonada.bsky.social for leading this initiative!

A small act of kindness: Blood donations get Sadie off the sidelines after her aplastic anemia diagnosis - Boston Children's Answers Sadie thrives with aplastic anemia Sadie was sidelined by aplastic anemia. Now she's back in the game, thanks to life-saving blood transfusions and expert care.

I am very proud to direct the Bone Marrow Failure Clinic at Dana-Farber/Boston Children's.
answers.childrenshospital.org/sadie-aplast...

based.

Temporal molecular program of human hematopoietic stem and progenitor cells after birth Zhang et al. provided an integral transcriptomic analysis of HSPCs, defined their dynamics in post-natal steady-state hematopoiesis, and refined the heterogeneity of MPPs by CD52 expression. Neonate bone-marrow-derived HSCs exhibited higher reconstruction capability than cord blood HSCs. This resource will help understand hematopoiesis in development and disease.

This paper still irritates me - harvesting marrow from one-day-old neonates (human!)
www.cell.com/developmenta...

The culmination. Thanks, John!

The dynamics of hematopoiesis over the human lifespan - Nature Methods This Resource presents an atlas classifying the age-related changes in human hematopoietic stem and progenitor cells from gestation through aging.

Hey all you #ASH24 people.
You need to look at this new paper in @naturemethods.bsky.social by Heme extraordinaires Grant Rowe and the Bluesky-less #HojunLi.

A paper that looks at Blood & Time from @bloodandtime.bsky.social himself!

#scRNAseq
#bioinformatics
🧬 💻

www.nature.com/articles/s41...

The nice thing about the jet lag is that I can watch Dr Ambros's Nobel lecture #ASH24

Ratio this post.