Educational Session: βDysregulation of nuclear topology in cancer: Clinical implications and emerging mechanismsβ
Presenter:
@thedoctorisvin.bsky.social
April 25, 2025, 3:30 PM - 3:50 PM CST/ 4:30 PM - 4:50 PM EST
25.04.2025 14:14 β π 3 π 2 π¬ 1 π 0
If youβre at @theaacr.bsky.social donβt miss todayβs session on 3D Topology & Cancer featuring giants of the field: Jane Skok @nyulangone.bsky.social & Brad Cairns @utah.edu
Imposter syndrome at an all time high! π¬
Proud to represent @cohesinlab.bsky.social @columbiacancer.bsky.social #AACR25
25.04.2025 12:57 β π 10 π 4 π¬ 0 π 0
Cohesin-dependent regulation of Runx genes
Runx transcription factors determine cell fate in many lineages. Maintaining balanced levels of Runx proteins is crucial, as deregulated expression leads to cancers and developmental disorders. We con...
And is it just FLI1? We donβt think so! Actually a HUGE part of this mechanism coming into focus was it helps us unify our prior PU.1 finding and may explain your zebrafish runx1 data that has been the inspiration for so much of our work! journals.biologists.com/dev/article/...
18.04.2025 11:58 β π 1 π 0 π¬ 0 π 0
Nope! No change in my overall expression by RNA or proteinβbut a redistribution of the protein towards a much higher chromatin-bound fraction.
And we think this disordering of the FLI1 cistrome is a big part of the mechanism!
18.04.2025 11:52 β π 1 π 0 π¬ 1 π 0
ππ Check out our first pre-print!
10.04.2025 18:24 β π 4 π 0 π¬ 1 π 0
@damonrunyon.org @dorisdukefdn.bsky.social @columbiacancer.bsky.social @clevelandclinic.bsky.social @mskcancercenter.bsky.social @euralumni.bsky.social @columbiamed.bsky.social @cohesinlab.bsky.social
08.04.2025 17:57 β π 2 π 0 π¬ 0 π 0
Scientist studying chromatin organization in myeloid malignancies in the Tothova Lab at the Dana Farber Cancer Institute π©βπ¬ she/her
Husband, Father and grandfather, Datahound, Dog lover, Fan of Celtic music, Former NIGMS director, Former EiC of Science magazine, Stand Up for Science advisor, Pittsburgh, PA
NIH Dashboard: https://jeremymberg.github.io/jeremyberg.github.io/index.html
Physician-Scientist | University of Pennsylvania | Pol I, rRNA, Ribosomes, Chromatin, Transcription | Hematopoiesis and Leukemia | π©Έπ¬π§ͺπ§¬
https://paralkarlab.med.upenn.edu
Scientist studying blood cancer and therapy resistance at Penn. Views are my own.
Our goal is to understand how host niches, epi/genetics, aging, lifestyle and treatments influence residual cancer dormancy to detect, prevent and treat cancer relapse
https://montefioreeinstein.org/cancer/research/cdi
The mission of the American Association for Cancer Research (AACR) is to prevent and cure cancer through research, education, communication, collaboration, science policy and advocacy, and funding for cancer research.
A translational research lab @mskcancercenter.bsky.social focused on the immunobiology and therapeutic potential of genetically engineered #Tcells and #TCRs. Est. 2016 @NYC
Howard Hughes Medical Institute (HHMI) believes in the power of individuals to advance science through research and science education, making discoveries that benefit humanity.
Weβre the world's leading independent cancer charity dedicated to saving lives through research, influence and information.
linktr.ee/cr_uk
Founder & Editor, Timmerman Report.
Albert Einstein College of Medicine: Educating students to become caring, skilled physicians and fostering biomedical and translational research.
Making Foundational Discoveries @fredhutch.bsky.social.
fredhutch.org/basicsciences
St. Jude Children's Research Hospital: a leader in research and treatment of pediatric cancer and childhood diseases.
Highlighting Stanford Medicine's world-class cancer research, prevention, and treatment. The Stanford Cancer Institute is dedicated to transforming cancer care. https://med.stanford.edu/cancer.html
Assistant Professor at Cincinnati Children's Hospital Medical Center. We study leukemia stem cell metabolism. All views are my own.
"Definitely still a young hematology researcher (donβt ask how young) @Institut Curie | Big on participative research & quant bio π§ͺ | Wannabe Intern at the Ministry of Silly Walks
Partnering with scientists to accelerate transformation in cancer research.
Hematologist-oncologist. Ajax Therapeutics CMO. Former Edward P. Evans Chair in #MDSsm at #DanaFarber; #HarvardMedicalSchool & #MayoClinic faculty, #Novartis global hematology head. @DavidSteensma