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@thedoctorisvin.bsky.social

76 Followers  |  185 Following  |  6 Posts  |  Joined: 07.04.2025  |  1.623

Latest posts by thedoctorisvin.bsky.social on Bluesky

Educational Session: β€œDysregulation of nuclear topology in cancer: Clinical implications and emerging mechanisms”
Presenter:
@thedoctorisvin.bsky.social
April 25, 2025, 3:30 PM - 3:50 PM CST/ 4:30 PM - 4:50 PM EST

25.04.2025 14:14 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
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If you’re at @theaacr.bsky.social don’t miss today’s session on 3D Topology & Cancer featuring giants of the field: Jane Skok @nyulangone.bsky.social & Brad Cairns @utah.edu

Imposter syndrome at an all time high! 😬

Proud to represent @cohesinlab.bsky.social @columbiacancer.bsky.social #AACR25

25.04.2025 12:57 β€” πŸ‘ 10    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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Cohesin-dependent regulation of Runx genes Runx transcription factors determine cell fate in many lineages. Maintaining balanced levels of Runx proteins is crucial, as deregulated expression leads to cancers and developmental disorders. We con...

And is it just FLI1? We don’t think so! Actually a HUGE part of this mechanism coming into focus was it helps us unify our prior PU.1 finding and may explain your zebrafish runx1 data that has been the inspiration for so much of our work! journals.biologists.com/dev/article/...

18.04.2025 11:58 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Nope! No change in my overall expression by RNA or proteinβ€”but a redistribution of the protein towards a much higher chromatin-bound fraction.

And we think this disordering of the FLI1 cistrome is a big part of the mechanism!

18.04.2025 11:52 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Preprint Watch: April Welcome to our monthly Preprint Watch, where we highlight some of the most relevant preprints for the ISEH community! This month we cover so...

Hey! Check out @drjanexu.bsky.social discussing @cohesinlab.bsky.social’s first preprint on @isehsociety.bsky.social simply blood preprint watch! www.simplyblood.org/2025/04/prep...

17.04.2025 18:38 β€” πŸ‘ 7    πŸ” 2    πŸ’¬ 2    πŸ“Œ 1

πŸ‘‡πŸ‘‡ Check out our first pre-print!

10.04.2025 18:24 β€” πŸ‘ 4    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

@damonrunyon.org @dorisdukefdn.bsky.social @columbiacancer.bsky.social @clevelandclinic.bsky.social @mskcancercenter.bsky.social @euralumni.bsky.social @columbiamed.bsky.social @cohesinlab.bsky.social

08.04.2025 17:57 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

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