Webvision

Four camera-type eyes in the earliest vertebrates from the Cambrian Period - Nature Early vertebrates, particularly myllokunmingids, possessed four camera-type eyes (a pair of lateral eyes and pineal and parapineal organs), which indicates that these structures functio...

New paper presenting rather compelling evidence that the stem-vertebrate Haikouichthys had paired lateral and supranumerary medial eyes (!!!), and proposing that the medial eyes may have deep homology with the pineal and parapineal organs.

www.nature.com/articles/s41...

ipRGC properties prevent light from shifting the SCN clock during daytime Nature - The inability of intrinsically photosensitive retinal ganglion cells to shift the circadian clock in the suprachiasmatic nucleus during daytime is caused by light-dependent depolarization...

A new paper from my lab. I will have a full description soon. rdcu.be/eX1Ld

Studying vision across light levels? Interested in rod photoreceptors and related (patho)physiology? Matteo Rizzi, Kate Powell and I wrote a review on rod photoreceptor activity at daylight doi.org/10.1016/j.vi... . Free access link here kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...

I'm so excited that @christ3na.bsky.social 's paper describing temporal control of photoreceptor development in human organoids is out at Genes and Dev and we got the cover!

genesdev.cshlp.org/content/40/1...

genesdev.cshlp.org/content/40/1...

Hey, @drdorotask.bsky.social is here on Bsky!

Such cool work.

We think that retinas degenerate with time and that if all of us live long enough, we’ll get AMD or other neurodegenerative diseases.

But Greenland sharks manage to live for hundreds of years and repair their eyes.

How?

Decoupling of visual feature selectivity in the retinocollicular pathway Schwartz and Matsumoto et al. show that visual feature selectivity for luminance and motion is coupled in the retina but becomes decoupled in the superior colliculus. This transformation reorganizes t...

Excited to share our new work on visual information processing in the retinocollicular pathway. We discovered that while luminance responses can predict motion responses in retinal ganglion cells, this prediction does not hold in the superior colliculus cells.

www.cell.com/current-biol...

Vision scientist Pete Williams talking at the lectern.

It’s @petetheteapot.bsky.social at the Retinal Ganglion Cell meeting talking about his work in gene therapy targeting neuroprotection and neurodegeneration.

"All existing prosthetic vision systems — penetrating electrodes, cortical surface grids, retinal implants, optogenetics, or sensory substitution — deliver signals that differ drastically from natural retinal coding. The brain must reinterpret foreign codebooks under bandwidth and noise constraints"

Vision scientist Michel Cayouette speaking at the lectern.

It is @michelcayouette.bsky.social speaking at the Retinal Ganglion Cell Meeting.

Vision scientist Richard Eva talking at the lectern.

It’s @richardevalab.bsky.social speaking at the Retinal Ganglion Cell Meeting about his work in retinal neuroprotection and optic nerve regeneration.

Vision scientist John Ash talking at the lectern.

It’s @john-ash8831.bsky.social talking at the Retinal Ganglion Cell Meeting about his work in retinal neuroprotection with combination therapy.

An image of a whole frog eye that has been labelled with a photoreceptor marker (cyan) and a nuclear marker (orange). The retinal is the striped tissue and the lens is the large round tissue with the orange interior. You can also see the optic nerve at the top middle of the picture (12:00).

Frog eye, frog eye. Can I have a confocal microscope to play on for 12 hrs a day again please? 👉👈🥺 🐸

Depends upon application for sure. But I made @webvision.bsky.social CC BY-NC for that content. www.webvision.pitt.edu

Freshly out at @natcomms.nature.com ! Our @univie.ac.at @awi.de @viennabiocenter.bsky.social @ercgrantees.bsky.social research into neurogenic plasticity of adult worm brains, and similarities in stem cells supporting growth of camera-type eyes. www.nature.com/articles/s41... [1/7]

Buenos días, ojazos 👀

A great talk by @cuilab.bsky.social at the Retinal Ganglion Cell meeting.

It’s @a-alexandris.bsky.social talking at the Retinal Ganglion Cell Meeting about his work in axonal degeneration.

Trying to find some protocols for cone isolation from frogs that don't involve transgenics or freezing. There is a surprising dearth of information out there for cone isolation? Seems to be mostly rods. Is anyone familiar with any simple-ish protocols? 🧪 👀 #xenopus

S-cone-specific circuitry in the outer plexiform layer of a cone-dominant mammal | PNAS In the vertebrate retina, short wavelength-sensitive S-cones and their downstream interneurons play unique roles in both image forming and non-imag...

Extremely proud to share our publication on S-cone circuitry in the ground squirrel, newly available this week in PNAS. We've been staring at these reconstructions for a long time, and I'm excited for others to see the results. 1/n

www.pnas.org/doi/10.1073/...

Just a heads up: I just got a phishing attempt pretending to be from the #VisualSystemDevelopment #GRC. It looked pretty convincing at first glance, so be careful!

That image is from 1961 and an idealization. Here is an actual trajectory of fixational eye movements. The dots are 2 ms apart. If a midget ganglion cell, with single-cone receptive field, fires at 100 Hz, then every spike reports about a different cone. How can we ever read anything?

#FluorescenceFriday

A sky of light within ✨
This is the ganglion cell layer of the avian retina. The nerve fiber layer lies beneath like a soft green current, carrying quiet signals forward.

Sometimes to see the universe with its beautiful scattered stars, one only has to look inside.

Hey folks, this is a very cool opportunity for peeps to do an amazing postdoc in Sydney, Australia in translational vision research.

Excellent work @victorcalbiagueg.bsky.social !!!

Axonal pathfinding of zebrafish retinal ganglion cells forms the optic nerve. Credit to Dr. Matthew Bostock @houartlab.bsky.social. #ZebrafishZunday 🧪

Ending my #FluorescenceFriday with this beautiful avian retina image depicting the beautiful stratification in the avian eyes.
This is where complexity meets art.
#retina #avian #bird #plexiformlayer

Fantastic new paper from @pierre-mattar.bsky.social lab!

A picture of a crowd of people at the Foundation Fighting Blindness Vision Walk.

Nice turnout for the @fightblindness.bsky.social #VisionWalk in Pittsburgh.

#ShareYourVision

#FluorescenceFriday 🌿🔬 post:
Avian retina transduced with my AAVs carrying the #GluSNFR biosensor.
Bright blobs at the top mark photoreceptor terminals; meanwhile below, an RGC connects beautifully with bipolar cells, giving a glimpse of retinal circuitry in action.
#Retina #Neuroscience #AAV #2-P

A horizontally oriented inhibitory neuron (yellow) spans the mediolateral axis of the superficial superior colliculus, with dense axonal arborization suggestive of a role in collicular surround suppression. Retinal ganglion cell terminals expressing ChR2 are shown in cyan (following intraocular AAV injection), while magenta highlights VGAT+ neurons labeled via a reporter AAV-tdTomato in a VGAT-Cre mouse. Image credit Dr. Peng Cui

#Visual #salience generation involves center-surround dynamics, but what performs these computations? This study shows that the #SuperiorColliculus encodes center-surround dynamics under isolated conditions, and provides insights into the circuit implementation @plosbiology.org 🧪 plos.io/4n7RpsA