Webvision

Trying to find some protocols for cone isolation from frogs that don't involve transgenics or freezing. There is a surprising dearth of information out there for cone isolation? Seems to be mostly rods. Is anyone familiar with any simple-ish protocols? 🧪 👀 #xenopus

S-cone-specific circuitry in the outer plexiform layer of a cone-dominant mammal | PNAS In the vertebrate retina, short wavelength-sensitive S-cones and their downstream interneurons play unique roles in both image forming and non-imag...

Extremely proud to share our publication on S-cone circuitry in the ground squirrel, newly available this week in PNAS. We've been staring at these reconstructions for a long time, and I'm excited for others to see the results. 1/n

www.pnas.org/doi/10.1073/...

Just a heads up: I just got a phishing attempt pretending to be from the #VisualSystemDevelopment #GRC. It looked pretty convincing at first glance, so be careful!

That image is from 1961 and an idealization. Here is an actual trajectory of fixational eye movements. The dots are 2 ms apart. If a midget ganglion cell, with single-cone receptive field, fires at 100 Hz, then every spike reports about a different cone. How can we ever read anything?

#FluorescenceFriday

A sky of light within ✨
This is the ganglion cell layer of the avian retina. The nerve fiber layer lies beneath like a soft green current, carrying quiet signals forward.

Sometimes to see the universe with its beautiful scattered stars, one only has to look inside.

Hey folks, this is a very cool opportunity for peeps to do an amazing postdoc in Sydney, Australia in translational vision research.

Excellent work @victorcalbiagueg.bsky.social !!!

Axonal pathfinding of zebrafish retinal ganglion cells forms the optic nerve. Credit to Dr. Matthew Bostock @houartlab.bsky.social. #ZebrafishZunday 🧪

Ending my #FluorescenceFriday with this beautiful avian retina image depicting the beautiful stratification in the avian eyes.
This is where complexity meets art.
#retina #avian #bird #plexiformlayer

Fantastic new paper from @pierre-mattar.bsky.social lab!

A picture of a crowd of people at the Foundation Fighting Blindness Vision Walk.

Nice turnout for the @fightblindness.bsky.social #VisionWalk in Pittsburgh.

#ShareYourVision

#FluorescenceFriday 🌿🔬 post:
Avian retina transduced with my AAVs carrying the #GluSNFR biosensor.
Bright blobs at the top mark photoreceptor terminals; meanwhile below, an RGC connects beautifully with bipolar cells, giving a glimpse of retinal circuitry in action.
#Retina #Neuroscience #AAV #2-P

A horizontally oriented inhibitory neuron (yellow) spans the mediolateral axis of the superficial superior colliculus, with dense axonal arborization suggestive of a role in collicular surround suppression. Retinal ganglion cell terminals expressing ChR2 are shown in cyan (following intraocular AAV injection), while magenta highlights VGAT+ neurons labeled via a reporter AAV-tdTomato in a VGAT-Cre mouse. Image credit Dr. Peng Cui

#Visual #salience generation involves center-surround dynamics, but what performs these computations? This study shows that the #SuperiorColliculus encodes center-surround dynamics under isolated conditions, and provides insights into the circuit implementation @plosbiology.org 🧪 plos.io/4n7RpsA

Optogenetic stimulation of single ganglion cells in the living primate fovea Individual retinal ganglion cells are singularly activated in the living primate retina via an adaptive optics scanning light ophthalmoscope.

1of2) New from the ARIA lab in eLife: This article shows that it is possible to optogenetically activate single retinal ganglion cells in vivo in monkeys. This is an important step toward causal tests of the role of specific ganglion cell types in visual perception...

In @jgp.org, Horie, Kitano, Tachibana, Koike et al. show that TRPM1 deficiency in ON bipolar cells produces retinal ganglion cell oscillations in association with rod bipolar cell axon remodeling and reduced ON bipolar cell outputs rupress.org/jgp/article/...

#Neuroscience

Maison Deyrolle Avrill, 1953 by Robert Doisneau

Black and white portrait of vision scientist and biochemist Yuanyuan Chen.

Portrait: Yuanyuan Chen
#scientist #VisionScientist #biochemist
bryanwjones.com/2025/10/port...

A black and white portrait of a Kazakh student standing in a doorway in Prague.

Finally got around to posting the snapshots of walking around in Prague after the RD 2025 Meeting: bryanwjones.com/2025/09/walk...

Thanks Bryan! Nice pic of me. I don't even remember you taking it. Eagerly awaiting the Visionarium pics 😊

Subretinal Photovoltaic Implant to Restore Vision in Geographic Atrophy Due to AMD | NEJM Geographic atrophy due to age-related macular degeneration (AMD) is the leading cause of irreversible blindness and affects more than 5 million persons worldwide. No therapies to restore vision in ...

👁️ UPMC Vision Institute is restoring sight! The PRIMA wireless retinal implant + camera glasses helped patients with advanced macular degeneration regain functional vision. Over 80% saw measurable improvement. #VisionRestoration #Neuroprosthetics #UPMC #Pitt www.nejm.org/doi/full/10....

Black and white portrait of Vision Scientist Joanna Hagen.

Portrait: Joanna Hagen (In My Office)
bryanwjones.com/2025/10/port...
#scientist #VisionScientist

The evolutionary origins of synaptic proteins and their changing roles in different organisms across evolution Nature Reviews Neuroscience - Recent studies have shed further light on the evolutionary origins of chemical synapses, In this Review, Colgren and Burkhardt explore how ancient proteins were...

First neurons didn’t appear overnight. We trace their roots to ancient secretory cells - showing how lifestyle & behavior shaped the evolution of first synapses.🧠🌊 #Evolution #Neuroscience

Our latest in @natrevneuro.nature.com
Link: rdcu.be/eMX3E

@jeffcolgren.bsky.social @msarscentre.bsky.social

A photo looking down on 4 sets of feet in shoes.

4 sets of vision researcher feet

@john-ash8831.bsky.social
@fvinberg.bsky.social
Jeffrey Goldberg
And @bwjones.bsky.social

In Fruit Fly Eyes, UMass Boston Researcher Sees Potential Medical Discoveries Jens Rister, an associate professor in UMass Boston’s biology department, has just been awarded more than $1,700,000 in funding from the National Eye Institute of the NIH to research a protein that gu...

A new article on our National Eye Institute (NEI) - funded project on the mechanisms underlying color vision!
@umassboston.bsky.social
🪰👀🧪
www.umb.edu/news/recent-...

The Rod Bipolar Cell Pathway Contributes To Surround Responses In OFF Retinal Ganglion Cells Sensory neurons can be influenced by stimuli beyond their receptive field center, yet the mechanisms underlying this surround modulation remain poorly understood. In the retina, many OFF ganglion cell...

🚨 New preprint out from our lab!
📄 The Rod Bipolar Cell Pathway Contributes to Surround Responses in OFF Retinal Ganglion Cells
👉 www.biorxiv.org/content/10.1...

In the retina, amacrine cells boost contrast by silencing nearby signals, helping your brain detect edges and details. Retinal ganglion cells then send that refined picture to your brain through the optic nerve.
Data from @neuralmapping.bsky.social 👀🧠

Downregulation of Transducin Delays Photoreceptor Degeneration in P23H Rhodopsin Retinitis Pigmentosa In inherited blinding diseases, such as Retinitis Pigmentosa (RP), photoreceptors progressively degenerate, eventually leading to blindness. Unfortunately, effective treatments to prevent or delay vis...

Our new preprint is out.

Our study on Retinitis Pigmentosa animal model shows improved photoreceptor survival when rod transducin, a key protein involved in light signaling, is reduced.

@fvinberg.bsky.social
@moraneyecenter.bsky.social
@utah.edu
www.biorxiv.org/content/10.1...

Anna Franziska Köller, Frank Schmitz et al. from Saarland University investigate alterations of photoreceptor synaptic ribbons in the retina of a human patient with oculocutaneous albinism type 1 (OCA1).
doi.org/10.1167/iovs.66.13.14

YouTube video by arvoinfo ARVO 2026 Annual Meeting

#ARVO2026 registration is open! Join @arvoinfo.bsky.social in Denver (May 3-7) for an immersion of cutting-edge new eye/#VisionScience under the theme, Achieving precision ophthalmology through innovative #VisionResearch. Sign up early and save: https://youtu.be/OSpr4hlp1OM

I'm so excited to be hiring my first postdoc! If you love retinal biology and developing new therapeutics to cure blindness, please apply! Thank you to the @brightfocus.bsky.social for supporting my research and enabling me to grow my research team! external-careers.jobs.unsw.edu.au/cw/en/job/53...