Majumdar Lab at UVM

If you haven't gotten your #RNA lover that special gift for Valentine's yet, we have just the thing! Registration to our 8th annual symposium, RNA Therapeutics: From Concept to Clinic, June 24-26, 2026 @UMassChan.bsky.social! 'U' deserve it! #RNATx2025 🔬📷: @cansucolpan5 #RNAValentine buff.ly/vi22rN6

Our newest paper is out where we investigate how exogenous RNA triggers innate immune responses, such as PKR activation and stress granule assembly. rnajournal.cshlp.org/content/earl...

We need better structures to protect our own tribe.

Feeling real shade for my Japanese multipen collection (0.3mm coletos to the grave). Always looking for new recommendations!

Practical Systems That Keep My Academic Lab Running Lessons learned from building a collaborative, accountable lab

Running an academic research lab is hard.

I’ve learned that what matters most isn’t perfection, but clear expectations, consistent communication & shared responsibility.

My lab certainly isn’t flawless, but here are some thoughts on organizing a lab. go.unc.edu/SStManagement

To be clear, @aaas.org is saying “things are not bad at all” in science on the same day this op-ed was published by former NIH-ers is on the nose.

Just a complete disconnection from reality on AAAS’ part. I hope members will hold them accountable.

www.statnews.com/2026/01/10/n...

Gemini As Indiana Jones: How Gemini 3.0 Deciphered The Mystery Of A Nuremberg Chronicle Leaf’s 500-Year-Old Roundels – The GDELT Project

Gemini 3.0 Deciphered the Mystery of a Nuremberg Chronicle Leaf's | Discussion

Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits Gene regulatory networks encode the fundamental logic of cellular functions, but systematic network mapping remains challenging, especially in cell states relevant to human biology and disease. Here, ...

The first dataset from the Billion Cells Project to be released publicly.

www.biorxiv.org/content/10.6...

@rnasociety.bsky.social's RNA for All Initiative is here!
Members: Apply for up to $1,500 for projects to boost RNA education & outreach (no salaries/overheads).
Ideas: Awareness, youth engagement, accessibility & more!
Details/Apply: rnasociety.org/diversity
Deadline: Jan 7, 2026
#RNAforAll

I got postdoc money from the Sacklers. So no sticks or stones from me, but science is rightfully getting a new wave of incoming re:Epstein. A good time for some much needed self-assessment about "where is the line?"

Easy win: Avoid donors your staff calls Voldemort.

Epic #Boston

YouTube video by Debraj Shubham Ghose Movie S2 20230517

3/5 To identify the biological 'control knobs' of immune tissue, we utilized CD40L-induced B cell aggregates as a model system. We demonstrated that these structures function as liquid droplets, terming them B-Lymphocyte Organized Multicellular Blobs (BLOMBs). youtu.be/QAk2ayoVF0M

Having recently found that increasing the default font size on my phone was a dramatic quality of life improvement, placing an open call for recommendations like this for people who might be in denial of their aging husks. (Chatgpt didn't miss a beat).

KOSMOS, this week's buzzy AI scientist, posits that a coding mutation in a well-studied diabetes-related protein is functioning instead by mutated/cryptic exonic TFBS. Plausible, and totally fine to hypothesize; and word salad for an AI preprint is fine too. But horizon farther away than I thought.

Quite possibly the best thing you'll read all month.

"…Every time you flush the toilet, you may very well be feeding engineered reactor ecosystems that inspired discovery of the domain Archaea and cultivation of syntrophic archaea closely related to our ancestors".

Junior Group Leader for RNA-Biology, RNA-Technology or RNA-Medicine (f/m/d) - Würzburg (Stadt), Bayern (DE) job with Helmholtz-Institut für RNA-basierte Infektionsforschung (HIRI) | 12844907 #RNAexcellence Junior Group Leader Positions (f/m/d) Job advertisement no.:   089/2025 Starting date:                  As soon as possible. The con...

🚨 A fantastic opportunity to join HIRI to start your research group on RNA Biology 👇 www.nature.com/naturecareer...

Random grant writing tip.

I generally use 'drawing canvas' to insert figures. This keeps the legends and everything together. But there is one problem, text boxes inside the drawing canvas cannot cross the edge and text boxes are always bigger than the text.

Simultaneous induction of multiple classes of broadly neutralizing antibody precursors by combination germline-targeting immunization in nonhuman primates Simultaneous immunization with three germline-targeting immunogens primes multiple bnAb lineages in NHPs, advancing multiepitope HIV vaccine strategies.

In our latest vaccine immunology study we tested whether it is possible to simultaneously prime multiple classes of broadly neutralizing antibodies (bnAbs) against HIV using a combination of germline-targeting (GT) immunogens. www.science.org/doi/10.1126/...
@scienceimmuno.bsky.social @lji.org

Hung up on the all black dining room with black curtains.

Orleans County senator resigns following leaked racist group chat - VTDigger Sen. Sam Douglass apologized for the offense his comments caused and described hateful comments he’d received since news first broke. He released a long statement late Friday afternoon.

Vermont still has robust local and state news coverage which makes a real difference when scandals like this break: vtdigger.org/2025/10/17/o...

Thermo Fisher Scientific to Accelerate Life Science Breakthroughs with OpenAI WALTHAM, Mass., October 16, 2025--Thermo Fisher Scientific Inc. (NYSE: TMO), the world leader in serving science, announced plans to further increase the impact of Thermo Fisher’s proven growth strate...

Maybe AI can help us to imagine a future where sort by price is possible on Fisher. How a billion dollar middleman can have such an unusable website in 2025... I just don't get it. share.google/RTKfr8eZ3AXF...

We are recuiting a postdoc to join us at The University of Oslo. The candidate will investigate how T cells in the Germinal Center shape B cell and antibody quality. The projects include intravital 2-photon microscopy!

www.jobbnorge.no/en/available...

Lost Science is a new NYT series of accounts from scientists who have lost their jobs or funding. You can send your story to the Times here www.nytimes.com/2025/10/08/c...

This means a lot to me. I was very worried that we'd never confront the reality of a (micro)generation of biology undergraduates who pivot away from the life sciences or grad programs as the circumstances become untenable. Please consider speaking to the youngest among us!

Different results in different labs looking at activation of heterotrimeric G proteins. Was traced to use of dispo. plastic tubes v. reusable glass tubes (Fl) washed with Alconox detergent (Al). This led to groundbreaking biochemical and structural studies, such as pubmed.ncbi.nlm.nih.gov/7969474/

Pheromones (Archive Episode)

This is delightful.

pca.st/episode/1e1f...

For last 10 years - we have worked with thousands of organizations around the world helping support them in integrating foldscope programs.

To bring in a new cohort of organizations - we are re-launching “fast and curious” 2025 edition - apply and get a Foldscope trainer and Foldscopes for free!

Legend David Baltimore died yesterday. He understood the way things should work: "the real contribution of MIT is that it doesn't take itself too seriously. It takes ideas seriously, but the people are relatively informal. They are not self-aggrandizing the way academics can be."

Otoh, srbc gcs are the best gcs.