Gregor Bond

BTS Autumn Symposium - British Transplantation Society The Fundamentals of Transplantation: A Joint Educational Event by The Herrick Society of Trainees in Transplant Surgery & The British Transplant Physician Trainees

thanks 🙏 BTS for the invitation!
what a warm welcome to london 🇬🇧

I guess DSA, GEP, ddcfDNA and TTV will nicely come together as comprehensive immune monitoring post SOT

bts.org.uk/bts-autumn-s...

#TTVguide

Immune Monitoring Goes Viral 🦠 Torque Teno Virus
for Immunologic Risk Stratification After Kidney Transplantation

⏩️ new review in TI 🔥

doi.org/10.3389/ti.2...
#ttvguide

Kidney Week in Houston: Day 1 — NephJC in this edition: Atacicept in IgAN; Albuminuria as a surrogate outcome, Renal Remission and additional CONFIDENCE analysis

the cure for kidney week FOMO 😀

www.nephjc.com/news/kidneyw...

The second sibeprenlimab paper in @nejm.org

(At least we gave it an oral at #KidneyWk unlike the poster for the phase 2 data in 2023!)

www.nejm.org/doi/full/10....

Balcinrenone in combination with dapagliflozin compared with dapagliflozin alone in patients with chronic kidney disease and albuminuria: a randomised, active-controlled double-blind, phase 2b clinica... In participants with chronic kidney disease at increased risk of disease progression, a fixed dose combination of balcinrenone and dapagliflozin was superior to dapagliflozin alone in reducing albumin...

And another ns-MRA

Balcinrenone added to Dapa in proteinuric CKD

#KidneyWK

@thelancet.com

www.thelancet.com/journals/lan...

American Society of Nephrology Kidney Week 2025 Original Article | Nov. 6, 2025 | NEJM.org A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy Figure 2A. Change from Baseline in 24-Hr Urinary Protein-to-Creatinine Ratio through Week 36. The NEJM identity sits at the bottom.

ORIGIN phase 3 trial: In an interim analysis of a clinical trial, atacicept, a fusion protein that binds and inhibits two cytokines thought to be central to the pathophysiology of IgA nephropathy, significantly reduced proteinuria. nej.md/3JEq8QL

@asnkidney.bsky.social | #KidneyWk

Figure 2. Change in bodyweight (A) Mean percent change in bodyweight from baseline to week 48, shown as observed means and bars indicating SEs. The model-based estimates of the mean percent change in bodyweight and differences among treatment groups at week 48 with the corresponding p values (efficacy estimand only) and 95% CIs are shown in (B) (efficacy estimand) and (D) (treatment-regimen estimand); bars indicate SEs. Multiplicity adjustment was not performed, and p values should be interpreted as exploratory. (C) shows the percentage of participants with bodyweight reductions of at least 5%, 10%, 15%, 20%, 25%, and 30% from baseline to week 48. The percentage of participants is annotated above each bar, calculated with the use of Rubin's rules by combining the percentages of participants who met the thresholds in imputed datasets. *The model-based estimates and 95% CIs from a mixed model repeated measures analysis for the efficacy estimand are shown on the right, denoted by 48.

Eli Lilly continuing to hit it out the park

Selective amylin agonist as an alternative to GLP1RAs? #eloralintide

www.thelancet.com/journals/lan... in @thelancet.com

(Yeah I know it’s #KidneyWk but what do we do till Houston wakes up!)

cc @rnflex.bsky.social

A meta-analysis of albuminuria as a surrogate endpoint for kidney failure - Nature Medicine In a meta-analysis of 48 randomized trials of chronic kidney disease progression, reduction in the 6-month urinary albumin:creatinine ratio was associated with lower hazard ratios of established kidne...

Another simultaneous publication from the afternoon session

Albuminuria as an acceptable surrogate outcome (per our discussion earlier today)

www.nature.com/articles/s41... in @naturemedicine.bsky.social @nature.com sadly paywalled

#KidneyWk

A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury This trial examines whether a conservative dialysis strategy can improve recovery of kidney function for patients with acute kidney injury who require dialysis.

a conservative dialysis strategy in possibly recovering AKI helps people recover faster!

jamanetwork.com/journals/jam...

in @jama.com from #KidneyWk

Like STARRT-AKi et al, at the other end? Small trial - needs replication or this is common sense?

low dose Tac + Everolimus is not superior to Tac + MMF in older transplant recipients

in @asnpublications.bsky.social

another LBCT from #KidneyWk published

journals.lww.com/jasn/fulltex...

My Hot Take on PISCES, the New Fish Oil in Hemodialysis Study I love when a new study challenges what we think we know.

jamesstein18.substack.com/p/my-hot-tak...

Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis | NEJM Cardiovascular disease is the leading cause of death in patients receiving hemodialysis, yet effective preventive therapies remain limited. Supplementation with n−3 polyunsaturated fatty acids, esp...

😲 too good to be true?

nothing except tx reduces death on hd
and now….

something safe, cheep and with more effect than tx (and more effect than in non hd)

waiting for the @freelyfiltered.bsky.social podcast covering this paper

www.nejm.org/doi/full/10....

Visual abstract Sad story reflecting that most people start with HD and most of them die

Natural history of RRT from the ERA registry

The visual abstract in this case tells a lot

academic.oup.com/ndt/advance-...

@ndt-era.bsky.social #NephSky

>50% hd to death 😥

Should we be screening every young child’s urine (as is done in some countries!)

@rheaultm.bsky.social and Oliver Gross make the case in @kireports.bsky.social

www.kireports.org/article/S246...

Main issue: we have therapeutic options!

#NephSky

Statistical analysis plan for TTVguideIT—a multicentre, patient- and assessor-blinded, non-inferiority, randomised and controlled phase II trial to compare standard and Torque Teno virus-guided immuno... Background Non-interventional studies indicate an association between Torque Teno Virus (TTV) load in peripheral blood and immunosuppression related outcomes in kidney transplant recipients. This make...

can viruses 🦠 be superheroes 🦸‍♂️ ?

PhD student Felix Herkner just published the statistical analysis plan
of the TTVguideIT trial 💪👏

Torque Teno virus guided immunosuppression #TTVguide

data cleaning until Q1/26
analysis Q2/26

trialsjournal.biomedcentral.com/articles/10....

Novartis Fabhalta® (iptacopan) meets Phase III primary endpoint, slows kidney function decline in patients with IgA nephropathy (IgAN)

As expected, Iptacopan phase 3 in IgA nephropathy slows GFR decline

APPLAUSE-IgA

Adding another new medication we won’t be able to access or afford to our IgA armamentarium

#NephSky

www.novartis.com/news/media-r...

A Phase 3 Trial of Telitacicept for Systemic Lupus Erythematosus | NEJM Telitacicept, a new dual inhibitor of the cytokines B-lymphocyte stimulator (BLyS) and APRIL (a proliferation-inducing ligand), showed efficacy in adults with active systemic lupus erythematosus (S...

Big win for telitacicept in SLE (not lupus nephritis, yet)

www.nejm.org/doi/full/10....

BAFF + APRIL FTW

#nephSky #Lupus

congrats to the poster price 🥳

viruses 🦠 can be superheroes 🦸‍♀️

Felix Herkner present
the statistical analysis plan
of the TTVguideIT trial
at the Austrian Transplant Congress

Torque Teni Virus guided immunosuppression #TTVguide

ah grad auf pubmed gefunden… und sie plant eine randomisiert kontrollierte studie zum thema apherese… find ich super… genau so eine studie fehlt

und wieso reicht sie nicht einfach einen antrag ein zur finanzierung ihrer wissenschaft bei drittmittelgebern, so wie alle anderen das machen, die auch forschung in der medizin machen und 0 oeffentlich gelder bekommen?

wo ist die studie zur „autoantikoerper entfernung“ publiziert?

happy to speak about TT virus 🦠 @Italien 🇮🇹 micro biology congress

TTV based immune monotoring
#TTVguide

mhm that makes me curiouse to have a look at the calculations of the DSMB that led to the termination of the trial; must have been a tought decision

mhm that makes me curiouse to have a look at the calculations of the DSMB that led to the termination of the trial

well written; as a kidney doc I would just not agree that protein is bad for your kidneys

SGLT2 Inhibitors and GLP-1 Receptor Agonists in Kidney... : Transplantation ovascular and kidney benefits in non-KT recipients, but evidence in KT recipients remains limited. This systematic review and meta-analysis provide updated evidence on the efficacy and safety of SGLT2...

>7.000 kidney transplant recipients
on SGLT2 inhibitors & GLP-1RAs

▶️ better survival, cardiovascular & kidney outcomes, weight loss, lower HbA1c

no safety risks
tinyurl.com/4p6fdybn