Hans-Joachim Anders

CKD prevalence in elderly and the eGFR inflation effect, a very important paper in the @ndt-era.bsky.social . Not just for elderly but also for the young CKD population

academic.oup.com/ndt/article/...

#nephinp
#nephrology_in_practice

A must read comprehensive article @ndt-era.bsky.social focusing on the biology/genetics of kidney stone. It highlights GWASs of calcium and phosphate handling (e.g., SLC34A1, CYP24A1, CaSR) and crystallization inhibitors (e.g., UMOD, pyrophosphate-related genes).
academic.oup.com/ndt/article-...

The New England Journal of Medicine Reduction of Antihypertensive Treatment in Nursing Home Residents A Research Summary based on Benetos A et al. | 10.1056/NEJMoa2508157 | Published on August 29, 2025 Visual representations of the patients in the trial and the treatments they were assigned. Read the full Research Summary at NEJM.org.

In older patients with frailty who were receiving antihypertensive drugs and had a systolic blood pressure below 130 mm Hg, reducing antihypertensive drugs did not lead to lower all-cause mortality over 4 years than usual care. Full RETREAT-FRAIL trial results and Research Summary: nej.md/45NUK9v

The fundamental difference between water and salt water (volume) was better known at the time of Homer Smith, where they wondered how the salmon can start and end life in fresh water while spending most of life in salt water

Sodium glucose cotransporter 2 inhibition does not improve active lupus nephritis in MRLlpr/lpr mice

doi.org/10.1016/j.kint.2025.09.026

#NephSky #MedSky #lupus #nupusnephritis #kidneydisease
@vhir.bsky.social @lmumuenchen.bsky.social @hjanders.bsky.social @pepasolerr.bsky.social

Now open access in @ndt-era.bsky.social

Rationale, Design, and Baseline Characteristics of the TRANSCEND-CKD trial of Retatrutide in pts with CKD

🧐Retatrutide is a novel triple incretin agonist targeting GIP, GLP-1, and glucagon receptors

▶️ academic.oup.com/ndt/article/...

Now open access in @ndt-era.bsky.social

Autosomal Dominant Tubulointerstitial Kidney Disease (ADTKD) in Chinese Pts

🧐This Chinese ADTKD cohort reveals a high prevalence of UMOD and HNF1B variants

▶️ academic.oup.com/ndt/article-...

Now online in @ndt-era.bsky.social

Neutrophil infiltration of kidney grafts: incidence, associated factors and graft survival

🧐NTI should prompt the search for urinary tract infection and rejection

▶️ academic.oup.com/ndt/article-...

Now online in @ndt-era.bsky.social

Recombinant alpha-1 microglobulin to improve outcomes in survivors of AKI

🧐RMC-035 may improve kidney outcomes in settings characterized by oxidative and ischemia-reperfusion injury.

▶️ academic.oup.com/ndt/article-...

🧬Complement Pathways and Regulators in Kidney Ds

doi.org/10.1093/ndt/...

@hjanders.bsky.social

Now open access in @ndt-era.bsky.social

How can we target the production of pathogenic IgA in IgAN?

🧐Drugs directed at mucosal B cells, inhibitors of APRIL and BAFF, and drugs that target IgA-producing plasma cells

▶️https://academic.oup.com/ndt/article/doi/10.1093/ndt/gfaf185/8262262

Now online in @ndt-era.bsky.social

Recombinant alpha-1 microglobulin to improve outcomes in survivors of AKI

🧐RMC-035 may improve kidney outcomes in settings characterized by oxidative and ischemia-reperfusion injury.

▶️ academic.oup.com/ndt/article-...

Now open access in @ndt-era.bsky.social

Prevalence of Strongyloides stercoralis in HD pts in Vienna

🧐Implementation of targeted screening for S. stercoralis should be considered in pre-KTX protocols in Europe.

▶️ academic.oup.com/ndt/article/...

Now open access in @ndt-era.bsky.social

QT-Prolonging Medications: Prevalence of Use and Associated Risks in CKD

🧐The pathophysiological relevance, prevalence, and CV consequences of QT-prolonging drug use in the CKD setting

▶️https://academic.oup.com/ndt/article/doi/10.1093/ndt/gfaf196/8263915

Now open access in @NDTsocial

Anti-GBM disease - Treatment Standard

🧐 Anti-GBM and ANCA positive pts have a higher relapse risk and require maintenance immunosuppressive treatment

▶️ academic.oup.com/ndt/article/...

Now open access in @ndt-era.bsky.social

Comparing CKD populations with T1D and T2D based on FINE-ONE and FIDELITY populations

🧐Similarities between populations may inform the translation of clinical evidence on finerenone from CKD and T2D to CKD and T1D.

▶️ academic.oup.com/ndt/article/...

Now open access in @ndt-era.bsky.social al

CKD of unexplained cause (CKDx): A consensus statement by the Genes &Kidney Working Group of the ERA

🧐Check also our 2 open access editorials on this innovative concept.

▶️ academic.oup.com/ndt/article/...

Now online in @ndt-era.bsky.social

Transition of pts with hereditary nephropathies from pediatric to adult care
from WG Genes&Kidney of ERA and ESPN

🧐To improve health outcomes, pt empowerment, and engagement for young people with CKD.

▶️ academic.oup.com/ndt/article-...

New RCT online in @ndt-era.bsky.social

Additive Effects of Oral Calcitriol on pts with IgAN receiving RAS Blockade

🧐The addition of 0.25 μg/d calcitriol to RASi safely lowered residual proteinuria and slowed eGFR decline in pts with IgAN

▶️ academic.oup.com/ndt/article-...

Now open access in @ndt-era.bsky.social

Protein profiles and associated biological pathways among different etiologies of CKD: new insights from DAPA-CKD

🧐Distinct proteomic differences unravel the heterogeneous pathophysiology of human CKD.

▶️ academic.oup.com/ndt/article/...

Lipid-lowering agents in solid organ transplant recipients ABSTRACT. Although pre- and post-transplant dyslipidaemia is one of the most prevalent modifiable risk factors associated with an increased risk of major c

Which agent are you using in post kidney transplant dyslipidemia? statin, ezetimibe, PCSK9 modulators or bempedoic acid?
More info: academic.oup.com/ndt/article/...
@ndt-era.bsky.social, @hjanders.bsky.social

Acute kidney injury, acute kidney disease and chronic kidney disease: challenges and research perspectives
More info: academic.oup.com/ndt/article/...
@ndt-era.bsky.social, @hjanders.bsky.social

A step toward personalized medicine
More info: academic.oup.com/ndt/article/...
@ndt-era.bsky.social, @hjanders.bsky.social, @Richard Glassock, @Andrew Rule, @Aleksandar Denic, @delanaye.bsky.social

Cost-effectiveness of protein restricted diets in advanced CKD AbstractBackground. The dialysis costs are not sustainable everywhere, resulting in many avoidable deaths. Interventions that postpone the start of dialysi

Now online in @ndt-era.bsky.social

Cost-effectiveness of protein restricted diets in advanced CKD

🧐In pts adherent to diet prescription, low-protein diets delay the start of dialysis, improve survival, and save money

▶️ academic.oup.com/ndt/article-...

Now open access in @ndt-era.bsky.social

Anti-nephrin, anti-podocin and anti-Kirrel1 antibodies: Biological challenges and clinical implications

🧐 Clinical implementation of anti-slit diaphragm antibody testing = precision dx and tx in podocytopathies

▶️ academic.oup.com/ndt/article/...

Now open access in @ndt-era.bsky.social

What do RCTs teach us about the pathophysiology of human IgAN?

🧐B cells/PC produce the IgAN antigen GdIgA1 as well as the respective autoantibodies, hence targeting B cells/PC will be most clever.

▶️ academic.oup.com/ndt/article/...

Beautiful, please consider to submit to www.era-online.org/ndt-kidney-a... with the option to be selected for the cover page of @ndt-era.bsky.social

Now online in @ndt-era.bsky.social

Perlecan is a novel target of autoantibodies in anti-glomerular basement membrane disease

🧐Triple-positive pts (anti-type IV collagen, -laminin 521, and -perlecan) = highest prevalence of lung hemorrhage and ESKD

▶️ academic.oup.com/ndt/article-...

Now open access in @ndt-era.bsky.social

Evolving strategies for early diagnosis, proactive prevention and treatment of CKD

🧐"Inferior doctors provide KRT
Mediocre doctors treat CKD
Superior doctors prevent kidney disease"

▶️
academic.oup.com/ndt/article/...

Read this piece from the ERAKI working group at the @ndt-era.bsky.social regarding the results of the DEFENDER trial published last August @jama.com
academic.oup.com/ndt/article/...