Lars Henning

Camtös temadag "Varför så bråttom?" www.regionorebrolan.se/sv/forskning...
P1 Fabriken "Hopp för cancersjuka.Så kan AI revolutionera vården"
www.sverigesradio.se/avsnitt/hopp...

Lite väl positiv framställning på P1 Fabriken av AI inom sjukvården och diagnostik. Jag rekommenderar istället på fredag Cantös temadag "Varför så bråttom?" med en föreläsning om "Evidensgranskning av AI-baserade och andra medicintekniska produkter" och "Lärdomar av sjukvårdens digitalisering"

Thats the paper from Netherlands which weight-based immunotherapy Nivolumab och Pembrolizumab is based on pure.eur.nl/ws/portalfil...

One of the most fascinating academic-driven concepts in oncology is de-escalation. As the rich countries lived delusionally as if their resources were unlimited we are starting to learn from countries like India. Swedish Society of Oncology changed for almost 2 yrs ago to weight-based immunotherapy

Big recommendation to watch Chris Booth on the CHALLENGE-RCT for everybody interested in cancer and exercise youtu.be/bZTBZ33JtoI?...

I think I'd swallow arsenic before shopping at something called TrumpRx.

Exercise is Great but It’s Not a Cancer Drug The CHALLENGE trial ignited social media with its great story of exercise as a cancer therapeutic. But liking a conclusion is not a reason to stop thinking.

In my opinion the critique by non-expert in exercise physiology John Mandrola in www.sensible-med.com/p/exercise-i... was pulverized. It may be time for all cancer units globally to start working on implementing a structured exercise program for its cancer patients. #commonsense

Structured Exercise after Adjuvant Chemotherapy for Colon Cancer | NEJM Preclinical and observational studies suggest that exercise may improve cancer outcomes. However, definitive level 1 evidence is lacking. In this phase 3, randomized trial conducted at 55 centers, ...

I witnessed yesterday probably for me the best presentation ever of a cancer trial listening to a @csoncol.bsky.social session about the CHALLENGE-trial by Chris Booth with a hell of a ride & tour de force in the Q&A. Very inspiring comments by @eaeisenhauer.bsky.social
www.nejm.org/doi/full/10....

I senaste @swedishskeptics.bsky.social Folkvett lysande introduktion "Systematiska översikter: hur man slipper ägna tid åt osäkra resultat" från Alexander Snellman om varför välgjorda oberoende systematiska översikter är av så stor betydelse för varje kunskapsbaserad samhälle
folkvett.vof.se

JCVI statement on COVID-19 vaccination in 2025 and spring 2026

UK stopped recommending covid vaccination to pregnant women from spring 2025 to my knowledge.
www.gov.uk/government/p...

Recommendations for COVID-19 vaccination from September 1 2025 - The Public Health Agency of Sweden Swedish recommendations for COVID-19 vaccination focus on preventing severe illness and death. These national guidelines are regularly updated and adjusted in response to changes in the epidemiologica...

I missed also the outrage in media and social media about the decision of Public Health Agency in Sweden that from 1st september 2025 pregnant women are not recommended Covid vaccination anymore www.folkhalsomyndigheten.se/the-public-h...

Thats why HTA-units are so utterly important for every knowledge-driven society. Very interesting read by the way with refreshing balance.

Ending publication bias: A values-based approach to surface null and negative results Sharing knowledge is a fundamental principle within the scientific community, yet null and negative results are still being underreported. This Consensus View discusses the problem of such publication...

"Ending publication bias: A values-based approach to surface null and negative results"

Paper out today in PLoS Medicine by many of us who would like to see publication bias reduced or eliminated.

Especially happy that Registered Reports got shout-outs.

journals.plos.org/plosbiology/...

Looks also like a good learning example to illustrate the importance of taking your time to think through your PICO before starting a systematic review. In the search strategy they used "colorectal cancer" without mentioning rectal cancer or premalign lesions under exclusion-criterias.

Tack för att Du gett ett ordentligt feedback till Umeå Universitet. Och welcome to the capital of Scandinavia

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Science is not always as good as it appears on print in a research paper. Ready to be scared by finding nasty truths. Try out INSPECT-SR for checking the trustworthiness of trial results when you do systematic reviews.

A further problem is illustrated by the authors equating no treatment with placebo. For example, describing their second assumption, they state, ‘Implicit in this notation is that there is a single version of ‘no treatment’ that is consistently defined across all subjects in the RCT and external controls’ (p4). However, most clinical trials are add-on trials (Senn, 2002), even if not specifically identified as such. In placebo-controlled trials, one starts with standard of care and then subjects are either allocated to receive in addition the active treatment or a placebo to it. The statistical analysis plan for SUNFISH (F Hoffman-La-Roche Ltd, 2020) has a protocol summary as Appendix 1, which has this to say, ‘In addition to the study drug treatment, patients may continue to receive concomitant drug medication…’ (p186). This is very standard for clinical trials. It highlights that a key assumption in borrowing control data in this way is that there has been no evolution in the standard of care in the period since the trial.

One of the most common misunderstandings about the use and value of placebos in clinical RCTs, often made by both methodological experts and experienced trialists:

(from @stephensenn.bsky.social in academic.oup.com/jrsssa/advan...)

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Hon är ju sist så det går utmärkt att ta till sig de övriga föreläsare. Min personliga highlight är Mikael Hoffmann. Som jag saknar lakemedel från twitter-tider. Jag är helt medveten om att Agnes känns upprörande för en del av svenska befolkningen. En del älskar henne. Vi vill hålla oss till mitten.

This malpractice by our universities might have a huge collateral damage as public trust in our experts competence is endangered.

An example from UK that applies also to "innovation-friendly" 🇸🇪. If you are in 🇸🇪 the 10th of october you are very welcome to HTA-unit Camtö's swedishspeaking workshop in Örebro "Why in such a hurry- about evidence and introduction of new methods in healthcare". www.regionorebrolan.se/sv/forskning...

The scandal of unbelievable bad medical research gets the well-deserved public attention unfortunately only occasionally in highly polarised and politcized questions.

Ikväll får jag festa för första gången hos Old Fellows i Västerås

Mitt liv som hund

I appreciate academical clinical trials as the discussion-section often is written much more thoughtful than in industry-sponsored trials. This paragraph with the time of inclusion seems important to me. Wouldnt be other infections than covid be more important nowadays?

World Health: The Magazine of the World Health Organization. May 1980. smallpox is dead!

#ThrowbackThursday: In 1980 the 🌍🌎🌏 was declared #smallpox free, thanks to mass vaccination efforts.

Smallpox was an acute contagious disease caused by the variola virus. It was one of the most devastating diseases known to humanity. #VaccinesWork

Really concerning that they only had some concerns about randomization in non-randomized trials

The Indian Journal of Medical Ethics is known in Sweden due to a publishing scandale bsky.app/profile/lars...