@jccvila.bsky.social
Microbial evolutionary biologist at Stanford for most of the time. Radically queer liberal for the rest. πͺπΊπ³οΈβπ They/Them
One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential.
www.biorxiv.org/content/10.1...
1/n 𧡠Excited to share our new paper! We developed a framework to reveal hidden simplicity in how organisms adapt to different environments, particularly focusing on antibiotic resistance evolution. #EvolutionaryBiology #MachineLearning
15.05.2025 14:33 β π 38 π 22 π¬ 1 π 1My NSF PRFB on the genetics of female polymorphism in hummingbirds was terminated yesterday.
I don't have much to say, I'm just sad. We've discovered so much, and could have gone so much further.
If anyone else is in the same boat, esp postdocs, please reach out, it would be good to connect.
5 relative abundance plots arranged to have increasing compositional variability (variability across relative abundance samples, here vertical bars)
1/ Hey y'all, I'm excited to share my latest paper, which is out now in PNAS! We introduce FAVA, a statistical framework to measure compositional variability across microbiome samples. If you want to measure variability across a stacked bar plot, FAVA is for you! Paper: doi.org/10.1073/pnas...
14.03.2025 20:46 β π 207 π 73 π¬ 5 π 2Iβm thrilled to share my first ever publication, now published in PNAS! www.pnas.org/doi/10.1073/...
With mentorship from the amazing @ksxue.bsky.social, I looked at how the outcomes of species introductions to microbial communities are influenced by the number of introduced microbes.
How is functional variation at large-effect loci maintained in natural populations?
Thrilled to share our work showing how beneficial dominance reversal helps fruit flies maintain a resistance polymorphism as selection varies in their environment! A thread 𧡠1/n
www.biorxiv.org/content/10.1...
To measure the selective and dominance effects of the resistant Ace alleles on fitness in a semi-natural context, we used Paul Schmidt & @petrovadmitri.bsky.social powerful system combining field mesocosms with large-scale phenotypic and genomic measurements (Rudman et al 2022) 9/n
22.01.2025 19:44 β π 2 π 2 π¬ 1 π 0
Is it βwinner-takes allβ when the simplest living things compete? Check out my fresh publication on phage coexistence in Science and a thread below𧡠www.science.org/doi/10.1126/...
12.12.2024 19:22 β π 182 π 98 π¬ 5 π 11Apologies for linking the other place, I wanted to be able to tag everyone who was involved. I'm hoping that as a community we eventually decide that BlueSky becomes the default platform for sharing new results.
30.10.2023 18:08 β π 1 π 0 π¬ 0 π 0Huge thanks to all my co-authors including @mrebolleda.bsky.social and @jgoldford.bsky.social who are on here and all the others who are not . Here's a link to a longer thread explaining this work. twitter.com/jccvila/stat...
30.10.2023 18:03 β π 3 π 0 π¬ 1 π 01st post on here to share our new preprint: βMetabolic similarity and the predictability of microbial community assemblyβ. Metabolically similar carbon sources lead to predictably similar growth rates and by-products which leads to predictably similar communities
biorxiv.org/content/10.1... .
