Matt Padula

Principles for proper peer review

I'll just leave this here: jocnf.pubpub.org/pub/qag76ip8...

16/36 riders. I'll take that.

Matrix directs trophoblast differentiation in a bioprinted organoid model of early placental development - Nature Communications The placenta plays vital roles in supporting fetal development. Here, Richards et al. develop a high-throughput bioprinted trophoblast organoid model to recapitulate the microenvironment of the e...

Read more in @natcomms.nature.com by:
@clairerich.bsky.social
@lanamcclements.bsky.social
@mattpadula.bsky.social
@louisecole.bsky.social

🏫
@utsengage.bsky.social
@centenaryinstitute.bsky.social
@hmriaustralia.bsky.social
@garvaninstitute.bsky.social

www.nature.com/articles/s41...

Well, I had a "lie down" on a warm up of a stage. But got through the rest of the race. No idea of times, but I got third in class (yes, only 3 entries). Actually had fun. Typical loose Sydney dry dirt despite all the rain of last few weeks.

Not planning on being fast....

Medical update: last infusion of six cycles of chemo. It's done. Oncologist is predicting more sometime, but cancer gone AFAIAC. PET scan in November.

Feel tired but that's likely poor sleep. Have to ignore it cause I'm racing the MTB on Sunday....

Proteomics Webinar: DIA with FragPipe, DIA-NN, and Skyline
Presenters: Eduard Sabidó and Brendan MacLean
When: Tuesday, September 16, 8am (Pacific Time)
Register Now ... skyline.ms/project/home...

#massspec #proteomics

The dangerous logic behind the killing of Charlie Kirk Political extremism isn’t caused by other people saying things you don’t like. It’s caused by those people having no constructive way to air their frustrations.

This is really interesting and worth five minutes of your time to read.
www.smh.com.au/world/north-...

Pre-analytical drivers of bias in bead-enriched plasma proteomics | EMBO Molecular Medicine www.embopress.org/do...

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#proteomics #prot-paper

UTS, the university that forgot about its students If the university executive continues to dominate, we may be left with an institution rich in consultants but poor in teachers, researchers and students.

Perfectly encapsulates my feelings.

www.afr.com/work-and-car...

Cycling. Motos will kill me.

We are not the same. 😁

I tend to TRY and rebuild things first. Bikes normally do 10+ years of riding with me, until bits can't be sourced or geometry is that much better.

Regularly. Bike shop monkey has appeal.

Universities have lost their way, but cost-cutting and consultants are not the answer Last week in Sydney, we saw a melodrama acted out that could stand in for the state of Australian universities more generally.

UTS executive and council should read this. But I doubt they will.
theconversation.com/universities...

Post-Translationally Modified Proteoforms as Biomarkers: From Discovery to Clinical Use academic.oup.com/cli...

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#proteomics #prot-paper

Discipline implies you have to fight something, you have to push yourself to do something that you really don’t want to do. But passion says, ‘You're going to do this because you want to do it.’ There will be challenges along the way, but there's never the thought of giving up

Steve Vai: I’m not a very disciplined person; it was a passion. Because passion is a much more powerful engine of creation than discipline.

Something is rotten in Australia’s tertiary education. And UTS’s suspension of teaching courses is one of its biggest disgraces | Isobel Crealy If preparing teachers for NSW during an ongoing teacher shortage isn’t a public good, what is?

This: www.theguardian.com/commentisfre...

MASSyPupX: A FREE, open-source platform for off-site processing of shotgun DDA and DIA proteomics data.

✅ Runs on USB, PC, or server
✅ Pre-installed tools & libraries
✅ Perfect for education, collaboration & resource-limited labs

doi.org/10.1016/j.jp...
#Proteomics #DDA #DIA #Bioinformatics #FOSS

Why assume equilibrium? I have no evidence for or against that.

The thing I wonder about in these studies is that it implies that every microlitre of blood contains the same molecules at the same concentration as every other microlitre. That logic doesn't make sense to me.

I guess what I'm saying is that people are often driven by pursuit of wealth as a means of status. Cause how much money does one actually need.

Because the general public's definition of genius is someone who can do what they can't. Parting people with their money falls into this category, so billionaires are seen as geniuses.

There is a smaller intensity peak exactly 17 Da less (ammonia loss?) and a peak of similar intensity to that smaller peak at half its m/z. All 1+. None are on regular list of contaminants.

Joe Rogan gets universities better than a lot of university administrators.

Universities are supposed to be places where you tackle challenging ideas, and have your ideas challenged.

If you take that away, you don't have a university anymore. No matter what you put on your letterhead.

Those liking the post, have you seen this ion in your data?

I'm getting sick of editors and reviewers letting ridiculous terms like this through.

When analysing peptides from in-gel digests by LC-MS/MS, has anyone noticed a 1+ ion of m/z 1342.93 after washing the column with 80% ACN? We are leaving the pump at 80% ACN at 1uL/min for 5 mins after our usual 0-40% ACN gradient. Doesn't correspond to any contaminants. #massspechelp