Stone Cold Pillar

Oncogenic potential of SARS-CoV-2—targeting hallmarks of cancer pathways - Cell Communication and Signaling The 2019 outbreak of SARS-CoV-2 has caused a major worldwide health crisis with high rates of morbidity and death. Interestingly, it has also been linked to cancer, which begs the issue of whether it ...

Oncogenic potential of SARS-CoV-2: "the virus encodes several proteins that alter key signaling pathways associated with cancer hallmarks."

#LongCovid

biosignaling.biomedcentral.com/articles/10....

STAT news did a lot of this background research in their article, “A closer look at the new members of the CDC vaccine advisory panel” published yesterday. They are an excellent outlet for health news... TikTok video by Dr. Arghavan Salles

I went through all 8 ACIP nominees, with the help of @debunk-the-funk.bsky.social @statnews.com @tom.medsky.social @luckytran.com @ryanmarino.bsky.social @johnrossmd.bsky.social @elizabethjacobs.bsky.social

Don’t worry, it’s probably worse than you think!

(Too long to upload here) MedSky 🩺

IN THE UNITED STATES DISTRICT COURT FOR THE NORTHERN DISTRICT OF CALIFORNIA GAVIN NEWSOM, et al., Plaintiffs, Case No. 25-cv-04870-CRB v. DONALD J. TRUMP, et al, ORDER GRANTING PLAINTIFFS' APPLICATION FOR TEMPORARY RESTRAINING ORDER Defendants. On June 6, 2025, the federal government initiated immigration raids across the City of Los Angeles. Protests swiftly followed, and some individuals involved in those protests were unruly and even violent. State and local law enforcement responded. The following day, President Trump ordered that members of the California National Guard be federalized, and thereupon assumed control of those forces. At this early stage of the proceedings, the Court must determine whether the President followed the congressionally mandated procedure for his actions. He did not. His actions were illegal both exceeding the scope of his statutory authority and violating the Tenth Amendment to the United States Constitution. He must therefore return control of the California National Guard to the Governor of the State of California forthwith.

BREAKING: Judge Breyer orders Trump to "return control of the California National Guard" to CA Gov. Newsom, finding that Trump's order taking control was illegal because it did not follow the required procedure.

The order is stayed until noon Friday.

More to come at Law Dork: www.lawdork.com

Logo of Irish ME/CFS Association - for Information. Support & Research In March 2025, we sent nearly 3600 Irish GPs the following bundle: - 2-page covering letter - Flyer for free GP webinar with Dr Ros Vallings, "Key messages for Primary Care on the Diagnosis and Management of Post-Viral Fatigue Syndrome and ME/CFS" - Flyer for free 1-hour CPD course, "Improve your knowledge on diagnosis and management of myalgic encephalomyelitis (ME/CFS)" whose chief author is Dr Nina Muirhead - "Diagnosis and Management of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome" by Dr Stephanie Grach et al from the Mayo Clinic Proceedings journal (8 pages) "Myalgic encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer" by Peter Rowe et al (2 pages of extracts with link & QR code to fulltext) - "10-Minute NASA Lean Test Clinician Instructions" (Bateman Horne Center) (4 pages) - "What Is ME/CFS?" from the CDC (1 page) - "ME/CFS Guide for Primary Care" (from the UK ME Association) (A3-sized poster) - "Orthostatic Intolerance Overview" (Bateman Horne Center) (2022 version, minus refs)

🧵
This information bundle has gone out to 3600 Irish GPs in advance of the webinar on April 8.

Just 48 hours left if you want to send in your GP's details to get a bundle.

People in Ireland can also request a copy of the bundle for themselves

#MEcfs #CFS

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#COVID didn't end because Joe Biden said it had.
Or because airline execs lobbied to get sick workers back to work.
Or when most people decided to stop #masking and get back to "normal".
It's year 6 now, it's disabling us and will keep doing that as long as we ignore the facts.
#disability #mecfs

Long Covid warning: 'Silent organ damage is a real problem' Experts are urging the government to protect people from Long Covid, which they say could have already affected a quarter of a million New Zealanders.

www.rnz.co.nz/news/nationa...

Hippocampal subfield volume alterations and associations with severity measures in long COVID and ME/CFS: A 7T MRI study Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) patients share similar symptoms including post-exertional malaise, neurocognitive impairment, and memory loss. The neurocogni...

Australian research finds brain swelling in #LongCOVID and #MECFS patients, linked to memory and concentration issues. MRI showed a significantly larger hippocampal volume in affected individuals compared to healthy controls. The study included 17 long COVID, 29 ME/CFS patients, and 15 controls.

In just 16 days, NIH has shifted from actively including folks to expressly, explicitly & openly violating the constitution & anti-discrimination laws.

I have no doubt there’ll be an injunction—but undoubtedly they’ve already marked all the apps that hadn’t been disqualified based on race & gender

Exclusive | White House Preparing Order to Cut Thousands of Federal Health Workers The executive order could come as soon as next week, if the Trump administration goes ahead with plans, according to people familiar with the matter.

Exclusive: The White House is preparing an executive order to fire thousands of workers from the Department of Health and Human Services

US Government Websites Are Disappearing in Real Time A growing number of US government websites have gone offline as of Saturday, including several related to USAID and others focused on youth programs, Africa, and more.

NEW: USAID source says staff are scrambling to save archived copies of US regulations before they're gone & are being actively locked out of systems, including a publicly available database of USAID documents.

WIRED has built software to systematically check the status of 1,374 government domains.

Hello, friend!

a quote that says " good friends are like stars you don t always see them but you know they are there " Alt: a quote that says " good friends are like stars you don t always see them but you know they are there " over a dark gray starry background above black treetops

So excited to see so many familiar faces here

It’s such a mindfuck to see ppl walk around in LA without masks because we KNOW the air is toxic. Even if the AQI is good, 9/11 showed us that the air was deadly even though officials said it was safe. It’s mind boggling to see people walking around like everything is normal🧵1/

Here's an excellent review of how many different viruses play a role (in many different ways) in the pathogenesis of Rheumatic diseases.
www.translationalres.com/article/S193...
It lends weight to Prof. Prusty's model of #MEcfs
This is how their ideas potentially align: chatgpt.com/share/678897...

ATTN: If you are interviewed by DOGE, make sure your union dues are up to date. Ask your supervisor for administrative leave to speak to the EEO about filing a grievance for 1A (no union membership needed for that step.) This gets you on the record with your supervisor and the EEO.

Finland's epidemic 8 Jan 2025: deaths of 5-9 year olds are now 2.6 times higher than normal, and growing 23 percent annually (7.7 times in 10 years).
1/x

Wat is PEM, POTS en MCAS - C-support Patiënten met post-COVID ervaren vaak ook PEM, POTS (een vorm van dysautonomie) en/of MCAS

It's worth mentioning that the factsheet on PEM appears on a web page next to similar factsheets on POTS and MCAS (!)

www.c-support.nu/wat-is-pem-p...

I'm impressed by this handout on PEM. This is attached along with the information every GP needs to register patients with the Long COVID clinics in the Netherlands.

I will put the salient text below in thread.

COVID‐19 Infection Risk Assessment in a Kindergarten Utilizing Continuous Air Quality Monitoring Data Researchers and transnational public health organizations have recognized aerosol transmission as an essential route of COVID-19 transmission. Therefore, improving ventilation systems is now adopted ...

onlinelibrary.wiley.com/doi/full/10....

We need to treat fossil fuels like Big Tobacco To reduce the consumption of fossil fuels and stem disinformation that blocks effective climate action, a comprehensive ban on advertising, promotion and sponsorship of fossil fuel products and indust...

"Ban fossil fuel advertising. Remove lobbyists from negotiations. End subsidies. The science is clear, and the stakes couldn’t be higher. It’s time to treat fossil fuels like Big Tobacco."
www.nationalobserver.com/2024/12/01/o...

Infectious diseases killed Victorian children at alarming rates — their novels highlight the fragility of public health today Between 40% and 50% of children didn’t live past 5 in the US during the 19th century. Popular authors like Charles Dickens documented the common but no less gutting grief of losing a child.

theconversation.com/infectious-d...

California Declares an Emergency Over Bird Flu Officials have discovered the virus in 645 herds of dairy cattle, more than in any other state so far.

www.nytimes.com/2024/12/18/h...

Evolutionary tree of SARS-CoV-2 variants in radial format, scaled to divergence (number of mutations). All Greek letters were assigned between May and November 2021, and none since "Omicron", which is enormously more diverse and divergent than any other named variant. Data from Nextstrain.org.

Graph showing mutations in SARS-CoV-2 versus time. The virus is not running out of mutational space (if anything, the most recent variant clade was above the trend line). Data from Nextstrain.org.

Graph showing mutations in the SARS-CoV-2 spike protein over time. The virus is not running out of mutational space. There was a very large jump in divergence with the arrival of BA.2.86, which evolved within a single host over a period of a year or so. Data from Nextstrain.org.

Graph showing the consistent increase in immune escape of SARS-CoV-2 variants (versus BA.2) over time. Data from Nextstrain.org.

State of SARS-CoV-2 evolution (Nov. 2024).

The minimum for disabled people whose disability began before they could work enough quarters to qualify for SSDI is roughly half that.

Billionaires (that shouldn’t exist) are pressing millionaires in Congress to cut the paltry Social Security benefits of seniors & disabled people.
#FuckinParasites

Skeletal muscle adaptations and post-exertional malaise in long COVID When acute SARS-CoV-2 infections cause symptoms that persist longer than 3 months, this condition is termed long COVID. Symptoms experienced by patients often include myalgia, fatigue, brain fog, cognitive impairments, and post-exertional malaise (PEM), which is the worsening of symptoms following mental or physical exertion. There is little consensus on the pathophysiology of exercise-induced PEM and skeletal-muscle-related symptoms. In this opinion article we highlight intrinsic mitochondrial dysfunction, endothelial abnormalities, and a muscle fiber type shift towards a more glycolytic phenotype as main contributors to the reduced exercise capacity in long COVID. The mechanistic trigger for physical exercise to induce PEM is unknown, but rapid skeletal muscle tissue damage and intramuscular infiltration of immune cells contribute to PEM-related symptoms.

A comprehensive review on long COVID post-exertional malaise (PEM) symptoms and potential mechanism.

While there are no definitive treatments, ongoing trials explore options like immunoadsorption, dietary supplements, and anti-inflammatory/antiviral therapies.

#longCovid #MECFS #PEM

UK SequenceME: first of a kind genetic study "SequenceME will bring together experts from Oxford Nanopore Technologies, the University of Edinburgh and Action for ME, to uncover the root causes of ME ... The project builds on the DecodeME study, the world’s largest genetic study of ME led by the University of Edinburgh and Action for ME, which investigated whether common genetic variants were more likely to appear in those with ME than those without the condition. Over 17,000 participants who donated saliva samples to DecodeME have consented to further analysis and he SequenceME partners will seek to analyse them all." The project team are seeking £7 million to analyse the first 10,000 samples.

SequenceME: first of a kind genetic study

www.actionforme.org.uk/news/sequenc...

Image is from Science for ME weekly update

#MEcfs #CFS #pwme

Screenshot of abstract and first paragraph of introduction

The Impact of #LongCOVID on Employment & Well‑Being: A Qualitative Study of Patient Perspectives

link.springer.com/article/10.1...

"For those who continued working after their COVID-19 infection, the effort & energy required for work left little capacity to participate in other life activities"

Screenshot of title and first four paragraphs of linked document

News Release 16-Dec-2024

"#LongCOVID’s effects on employment: financial distress, fear of judgment: In study, patient perspectives highlight how providers can help"

www.eurekalert.org/news-release...

"their lives have been completely changed because of this chronic condition"

#PASC #PwLC

Autoantibodies to selenoprotein P in chronic fatigue syndrome suggest selenium transport impairment and acquired resistance to thyroid hormone Chronic Fatigue Syndrome (CFS) presents with symptoms of hypothyroidism, including mental and physical fatigue, poor sleep, depression, and anxiety. H…

www.sciencedirect.com/science/arti... “Autoantibodies to SELENOP are relatively frequent in chronic fatigue syndrome.
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SELENOP-aAb are associated with dysregulated GPx3 and DIO expression.
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Strongly reduced urinary iodine reflects low TH activation and DIO activity.” #mecfs