Jiuling Yang

KMT2C/KMT2D-dependent H3K4me1 mediates changes in DNA replication timing and origin activity during a cell fate transition Gökbuget et al. use machine learning to quantify chromatin state changes that predict DNA replication timing changes during cell differentiation. By following up on top predictors through functional v...

🚨 New Paper Alert! 🚨
Our latest study on KMT2C/KMT2D (mutated in 20% of cancers) reveals a new function for H3K4me1 in regulating DNA replication timing (RT) and origin activity during cell state transitions. Check it out: www.cell.com/cell-reports.... More info ⬇️

04.02.2025 17:06 — 👍 25    🔁 10    💬 2    📌 5

The FIRE biosensor illuminates iron regulatory protein activity and cellular iron homeostasis Iron is essential for life, yet the full context of its regulation in shaping cell fates in stem cells of the early developing mammalian embryo is not well understood. Sangokoya reports a ratiometric ...

Excited about the release of my lab's first paper🎉https://shorturl.at/ftC4f today, in print soon. many thanks to @bwfund.bsky.social NICHD/NIH UCSFPathology, @mdphdequity.bsky.social #UCSFWatsonScholar UCSFLiverCenter @ucsfstemcell.bsky.social for support in the first year of sangokoyalab.ucsf.edu

17.01.2025 02:15 — 👍 7    🔁 5    💬 1    📌 0

The glycosyltransferase ST3GAL4 drives immune evasion in acute myeloid leukemia by synthesizing ligands for the glyco-immune checkpoint receptor Siglec-9 - Leukemia Leukemia - The glycosyltransferase ST3GAL4 drives immune evasion in acute myeloid leukemia by synthesizing ligands for the glyco-immune checkpoint receptor Siglec-9

Excited to see this new #glycotime work from #proudofalumni Simon Wisnovsky's lab at UBC, identification of ST3GAL4 as mediator of Siglec-9 ligand biosynthesis in AML cells, which promotes immune evasion especially of macrophages.

www.nature.com/articles/s41...

19.11.2024 07:37 — 👍 59    🔁 7    💬 0    📌 0

In vivo CRISPR screens identify key modifiers of CAR T cell function in myeloma https://www.biorxiv.org/content/10.1101/2024.11.19.624352v1 Chimeric antigen receptor (CAR) T cells are highly effective in hematologic malignancies. However, l

In vivo CRISPR screens identify key modifiers of CAR T cell function in myeloma https://www.biorxiv.org/content/10.1101/2024.11.19.624352v1

20.11.2024 02:18 — 👍 10    🔁 3    💬 0    📌 0

Huaigeng Xu at the podium ready to give his presentation.

Huaigeng Xu at the retreat

Huaigeng is presenting his exciting work on developing cancer vaccines today at the UCSF Prostate Program retreat.

14.11.2024 20:11 — 👍 6    🔁 4    💬 2    📌 0

The Blelloch Lab held a retreat in the Tahoe National Forest this weekend. We decided to join the Bluesky Science Community.

11.11.2024 05:49 — 👍 10    🔁 3    💬 0    📌 0

Discovery of MD-265: A Potent MDM2 Degrader That Achieves Complete Tumor Regression and Improves Long-Term Survival of Mice with Leukemia MDM2 has been pursued as an attractive therapeutic target for human cancers. Herein, we describe our discovery of MD-265 as a promising PROTAC MDM2 degrader and extensive in vitro and in vivo evaluati...

I'm excited to share a new publication from my previous lab building on our earlier work on PROTAC degraders targeting MDM2 for cancer therapy. More efficient MDM2 degraders have been developed as we gain deeper insights into their mechanisms. Check it out if interested! pubs.acs.org/doi/full/10....

13.11.2024 19:02 — 👍 3    🔁 2    💬 0    📌 0