UCSF Broad Stem Cell Center

Thank you to all the incredible trainees, program directors, patient advocates, and inspiring speakers who joined us for the 2025 #CIRMTraineeConference!

We’re grateful for the insights you shared and the community we continue to build together in advancing #RegenerativeMedicine. #BlueskyBiotech

Astrocyte specification in the mouse septum is shaped by both developmental origin and local signals Nature Neuroscience - The relative contribution of intrinsic and extrinsic factors to astrocyte heterogeneity is unknown. Using heterotropic transplantation of septal astrocytes with distinct...

New in @natneuro.nature.com: Astrocyte fate isn’t hardwired — it’s shaped by where they grow up. Local neuron signals — not just where they come from — shape their identity. A key step toward understanding brain health and developing new therapies. rdcu.be/eyoIX #NewResearch

Curing Genetic Disease Before Life Begins with Tippi MacKenzie Fetal surgeon Tippi MacKenzie on curing genetic disease before birth using in utero therapy.

🎧 Don’t miss this podcast with Dr. Tippi MacKenzie, Broad Center Director, on in utero therapies & the future of regenerative medicine.

📍19:40: vision for the Center → discover, engineer, heal.

🔗 bit.ly/46qjYgi

#UCSF #StemCells #FetalSurgery #GeneTherapy #GenomeEditing #DiscoverEngineerHeal

Science x Art Science x Art - Innovative Genomics Institute (IGI)

Did you know that the illustrations in our resources like CRISPRpedia are free to use for non-commercial, educational purposes? Check out our Science x Art page to see a selection of work from our designers & artists. Tag us to show us how you're using them! innovativegenomics.org/science-x-art/ 🧬🎨

It's #WorldBrainDay!

The brain controls everything that makes life possible.

Scientific research provides the tools and knowledge needed to protect, restore, and enhance brain health for all.

Are you a #neurowiz?

Take this short quiz to find out: vist.ly/3yr5j

Why Is Discovery Research So Important? Neuroscientist Grae Davis, PhD, unpacks why public understanding of science matters.

Why Is Discovery Research So Important? Broad Center member Grae Davis unpacks how big breakthroughs happen and why public understanding of science matters: magazine.ucsf.edu/why-discover...

A full circle ⭕️ moment interviewing @ameliecollins79 . Dr. Collins was my fellow during my #neonatology sub-I. Fascinating #hsc work (the mother cell of #immunology!) ✅it out and her 😍publication: pubmed.ncbi.nlm.nih.gov/38428422/ @ucsfchildrens.bsky.social @ucsfstemcell.bsky.social

🚨 REMINDER: Prospective DISC4 applicants, the Pre-Submission Form deadline is June 16 at 2 PM.
The DISC4 Awards support large, cross-disciplinary teams working on innovative ways to understand and treat human disease. Learn more at www.cirm.ca.gov/disc4/.

We are thrilled that @semilc.bsky.social and the Choksi Lab will be part of our RMB community! 🎉

CBER Roundtable on Cell and Gene Therapy The Roundtable will provide you with an opportunity to share your thoughts on advancing the field of cell and gene therapy.

🔊 TOMORROW, June 5: Join @fda.gov’s Cell and Gene Therapy Roundtable featuring ASGCT Board Members Terry Flotte, Paula Cannon, and more, on the panel! Watch on YouTube from 9 a.m. to noon (ET).

Do not miss out on this opportunity to hear from top regulatory leaders! www.fda.gov/vaccines-blo...

Today! Join us for our Getting to Patients seminar. Dr. Matthay will share “Allogeneic Bone Marrow-Derived Mesenchymal Stromal Cells for ARDS: Pre-Clinical and Clinical Data” with patient perspective and discussion moderated by Dr. Julia Brown tiny.ucsf.edu/StromalCells... @ucsfsurgery.bsky.social

CIRM is excited to announce that we have launched our new funding programs: the DISC4 (for multidisciplinary, collaborative basic #research), #Preclinical Development (PDEV), and #ClinicalTrial (CLIN2) Awards!

Learn more about our funding programs on our website at www.cirm.ca.gov/researchers/...

The rapid advancement of CRISPR-Cas gene editing is transforming medicine, offering precise treatments for genetic disorders. Evaluating unintended effects remains crucial. UNCOVERseq, a new method, improves detection of off-target edits, enhancing the safety and effectiveness: bit.ly/UNCOVERseq

Slide for AGC 28th Annual Meeting keynote lecture by Tippi C. MacKenzie, MD, titled "Prenatal Gene Therapies for Severe, Early-Onset Genetic Diseases," scheduled for May 15.

Hear how gene therapies can address serious genetic diseases before birth. Dr. Tippi MacKenzie will deliver a George Stamatoyannopoulos Memorial Lecture at the @asgct.bsky.social Annual Meeting on May 15. #ASGCT2025 #GeneTherapy #PrenatalResearch #raredisease

We love to see and hear this! ☀️ Thank you, @elizabethcrouch.bsky.social 😀

Join us today for Getting to Patients! — 4 PM in HSW-300

The promise of cerebral organoids for neonatology : Current Opinion in Pediatrics . Human cell-derived cerebral organoid models are an appealing way to address some of these gaps. In this review, we will touch on previous work to model neonatal conditions in cerebral organoids, som...

#cerebralorganoids 🧠🧫hold much promise in #neonatology but have yet to deliver directly for our #patients 👶🏾👶🏻 We outline some high yield areas for future study (vasculature! Cortical circuits!) @ucsfchildrens.bsky.social @ucsfstemcell.bsky.social ✅it out! journals.lww.com/co-pediatric...

The Game is On: Meet the UCSF Grad Slam Finalists! Get ready for UCSF Grad Slam! The Graduate Division’s popular annual research communications contest returns on April 2 as part of UCSF’s celebration of National Graduate Student Appreciation Week.

So proud of #Crouchlab MSTP KWP (Kaylee Wedderburn-Pugh)! Come listen to her amazing talk on #bloodbrainbarrier gene modules during development @ucsfstemcell.bsky.social 🧠💻🧬 graduate.ucsf.edu/news/game-me...

Join us for Getting to Patients on Thurs, 3/20, in HSW-300! Drs. Peter Stock & Julie Sneddon share “Beta Cell Replacement Therapies for the Treatment of Diabetes Mellitus” with patient perspective and discussion with @juliaehbrown.bsky.social tiny.ucsf.edu/Diabetes

Meet the UCSF Pathologist Focused on Supporting Women in Science Carolyn, a UCSF pathology professor, founded a 100+ member women's physician-scientist group. It fosters collaboration and provides support to empower women across the university.

The incredible @rnahelix.bsky.social Dr. Carolyn Sangokoya and the formation of the Women’s physician scientists supergroup has had an incredible impact on my career! Great to see her celebrated!

www.ucsf.edu/news/2025/03...

Graphical abstract from the paper depicting the neural stem cells in the mouse ventricular subventricular zone (V-SVZ) over time. B2 cells are more prevalent in adults. B1 and B2 cells can be quiescent or active and can generate olfactory bulb neurons and oligodendrocytes. Publication citation: Cebrian-Silla A et al. Neural stem cell relay from B1 to B2 cells in the adult mouse ventricular-subventricular zone. Cell Rep. 2025 Feb 27;44(3):115264. doi: 10.1016/j.celrep.2025.115264. Epub ahead of print.

In @cp-cellreports.bsky.social, Arantxa Cebrian-Silla, PhD, Arturo Alvarez-Buylla, PhD, & their colleagues show that B2 cells are an important population of secondary neural stem cells that help sustain neurogenesis in adult mice: doi.org/10.1016/j.ce...
@ucsfstemcell.bsky.social #Neuroskyence

Celebrating International Women's Day 2025 at UCSF this week with a fabulous group of panelists Women in Science: Holding the Vision in Academic Science and Medicine March 7th 3pm PST shorturl.at/rVrdt

801: Dr. Kyle Cromer: Using Gene Editing to Create Enhanced Cell Therapies - People Behind the Science Podcast Listen to the Episode Below (0:56:00) 0.75x 1x 1.25x 1.5x 2x 0:000:56:00 801: Dr. Kyle Cromer: Using Gene Editing to Create Enhanced Cell Therapies Apple PodcastsGoogle PodcastsSpotifyPlayer EmbedShar...

We’re excited to share that Dr. Kyle Cromer was featured on the “People Behind the Science” podcast! Tune in to hear his insights on gene editing, innovative cell therapies, and his scientific journey.

Listen now: www.peoplebehindthescience.com/dr-kyle-crom...

Rick Sontag with past Sontag Distinguished Scientist Awardees from UCSF. Seated from left to right: Dan Lim, MD, PhD (DSA 2009), Tom Nowakowski, PhD (DSA 2021), and Cathryn Cadwell, MD, PhD (DSA 2024).

Grateful to the Sontag Foundation for their support of brain tumor research at UCSF! We’re glad to be catching up with our colleagues and collaborators this week at the annual Sontag Scientific Retreat. @ucsfcancer.bsky.social @ucsfstemcell.bsky.social

UCSF associate professor of neurosurgery Tomasz Nowakowski, PhD, presenting at the Sontag Foundation's 22nd Annual Scientific Retreat. His slide notes his collaborations with William Weiss, Mariella Filbin, Michael Taylor, Anna Kirchevsky and Gilbert Rahme. The title says, How do neural stem cells give rise to different cell types in the brain?

UCSF neuroscientist and 2021 Sontag Distinguished Scientist Tomasz Nowakowski, PhD, talking about how different types of cells in the brain develop at this year's Sontag Scientific Retreat. #neuroskyence @ucsfstemcell.bsky.social

🗳️ Voting is open! 🗳️

Your voice matters in shaping the future of the Society. Vote for new leadership positions, including Vice President, Treasurer, Clerk, and two Directors - plus the re-appointment of two Directors. Vote today👉 bit.ly/4h9vu1S

Late-breaking poster abstract submission is now open for the #ISSCR2025 Annual Meeting! Showcase your latest work, get valuable feedback, and connect with collaborators or future employers at The Global Stem Cell Event.

Abstracts due 19 March 2025👉 bit.ly/4ePsyGq

Using Genetic Sequencing and AI to Identify and Treat Schizophrenia Top left to right: Tomasz Nowakowski, PhD, and Nevan Krogan, PhD Bottom left to right: Aparna Bhaduri, PhD; Matt State, PhD; Alice Ting, PhD; Trey Ideker, PhD; Willow Coyote-Maestas, PhD As outline…

Neuroscientist Tomasz Nowakowski, PhD, is leading a collaborative CIRM-funded project using stem cell technologies & #AI to uncover how genetic mutations associated with schizophrenia impact brain development.
#Neuroskyence @ucsfstemcell.bsky.social @uclastemcell.bsky.social @aliceyting.bsky.social

Congratulations, @ucsfstemcell.bsky.social member David Schaffer, and all elected to the National Academy of Engineering! 🎉

Dr. Tippi MacKenzie of @ucsfstemcell.bsky.social is presenting, "Prenatal Therapies for Single Gene Disorders" at our Annual Stem Cell Symposium this Friday, February 7. #UCLAStemCell25

👉 Register now: bit.ly/3Cv2brO