Noel Research Group

First stop in USA East Coast lecture tour: Merck Rahway, great to discuss #FlowChemistry, #HTE, #SelfDrivingLabs and synthetic methodology with our friends in the pharma industry

Thanks Stephan for highlighting Dima’s work 🙏

Great talk by @dimanagornii.bsky.social from the group of Timothy Noël (@tnoel82.bsky.social) at #Lunteren2026. He talked about the late-stage modification of aryl compounds with NCF3 and SCF3 groups using flow chemistry.
chemrxiv.org/doi/full/10....
#ChemSky #FlowChemistry

📣 Thrilled to announce our incredible speaker lineup for the 2026 edition of #ETOC Online Symposium on April 29-30th.🗓️ Join us by registering today and to stay up-to-date! : tinyurl.com/ETOC2026-reg... (1/3)

📄 We report a radical disconnection strategy that enables the direct, single-step conversion of α-amino acids into differentiated vicinal diamines via photocatalytic decarboxylation.

Broad scope, functional-group tolerant, and scalable in flow.

🔗 @chemrxiv.org: chemrxiv.org/engage/chemr...

We combine ML + #DigitalTwins to autonomously design photoreactors with high light capture and uniform irradiation. A virtual photoreactor guides #BayesianOptimization, allowing numerous designs in silico and fabrication only of the best candidates.

🔗 @chemrxiv.org : chemrxiv.org/engage/chemr...

New @chemrxiv.bsky.social preprint!

RoboChem-Flex is a powerful, low-cost (<5k EUR), modular self-driving lab for chemical synthesis

We showcase 6 studies (photochemistry, biocatalysis, cross coupling, ee ...), all optimized with different configurations & ML

🔗 chemrxiv.org/engage/chemr...

📄 We report a radical disconnection strategy that enables the direct, single-step conversion of α-amino acids into differentiated vicinal diamines via photocatalytic decarboxylation.

Broad scope, functional-group tolerant, and scalable in flow.

🔗 @chemrxiv.org: chemrxiv.org/engage/chemr...

We combine ML + #DigitalTwins to autonomously design photoreactors with high light capture and uniform irradiation. A virtual photoreactor guides #BayesianOptimization, allowing numerous designs in silico and fabrication only of the best candidates.

🔗 @chemrxiv.org : chemrxiv.org/engage/chemr...

📄 New Paper Alert: We report a radical disconnection strategy that enables the direct, single-step photocatalytic conversion of α-amino acids into differentiated vicinal diamines.

Broad scope, functional-group tolerant, and scalable in flow.

🔗 @chemrxiv.org: chemrxiv.org/engage/chemr...

#RSCPoster is happening again on March 3rd and 4th, 2026, here on LinkedIn. I am happy to be involved as subject chair for #RSCChemBio.

If you want to share some exciting research in #Chemistry and especially #ChemBio consider registering for the event:

www.rsc.org/our-events/a...
#ChemSky

Nov 11, 11:30 AM EST: Join our next #ACSeminar ft. @tnoel82.bsky.social to learn about #RoboChem, an autonomous laboratory system that integrates flow reactors, real-time analytics, custom control software + machine learning algorithms.

Register: airtable.com/appYBjHgttvB...

My student forgot to add a stir bar to a biphasic reaction in a sealed container. I said let's go ahead and try after reading that paper. Lo and behold, we got almost no conversion. The reaction worked fine when resubjected with a stir bar. At least for biphasic reactions, it's still crucial to stir

Our ChemRxiv article keeps moving; thanks #ChemistryWorld for covering the debate. Critics say it’s “too early” for conclusions, yet mixing principles are grounded in 100+ years of science. Read and make up your own mind.

Here is our @chemrxiv.org article: chemrxiv.org/engage/chemr...

😂 this will be a great example to add 😂

Our ChemRxiv article keeps moving; thanks #ChemistryWorld for covering the debate. Critics say it’s “too early” for conclusions, yet mixing principles are grounded in 100+ years of science. Read and make up your own mind.

Here is our @chemrxiv.org article: chemrxiv.org/engage/chemr...

All stirred up: chemical engineers refute claims that ‘stirring doesn’t matter’ Failing to mix reactions in heterogeneous or industrial systems could cause numerous issues and might even be dangerous, preprint claims

Earlier this year, a paper came out that suggested for many organic reactions stirring has little effect on reactions rates. Now, a group has released a preprint arguing that stirring remains critical for reproducibility, selectivity and scalability.

Donna Blackmond opened yesterday's morning w/ a talk on mechanistic studies, followed by Timothy Noel @tnoel82.bsky.social who presented latest advancements in automated #FlowChemistry.
Join the FREE livestream 🎥 and follow TODAY's program: https://tinyurl.com/7mhrbyap
#BeilsteinShapingSynthesis2025

We built a machine learning–guided workflow to optimize reaction conditions for photochemical nickel-catalyzed cysteine arylation; no specialized robots or fancy HTE plates needed!

Check it out @chemrxiv.org : chemrxiv.org/engage/chemr...

#MachineLearning #ReactionOptimization

We built a machine learning–guided workflow to optimize reaction conditions for photochemical nickel-catalyzed cysteine arylation; no specialized robots or fancy HTE plates needed!

Check it out @chemrxiv.org : chemrxiv.org/engage/chemr...

#MachineLearning #ReactionOptimization

We felt a sense of urgency to summarize why mixing matters in synthetic organic chemistry.

Our takeaway: don’t toss those stir bars yet!
The truth is more complex than it may seem.

Read our ChemRxiv preprint: chemrxiv.org/engage/chemr...

#Chemistry #Mixing #Reproducibility

We felt a sense of urgency to summarize why mixing matters in synthetic organic chemistry.

Our takeaway: don’t toss those stir bars yet!
The truth is more complex than it may seem.

Read our ChemRxiv preprint: chemrxiv.org/engage/chemr...

#Chemistry #Mixing #Reproducibility

Don’t miss Timothy Noël @tnoel82.bsky.social (University of Amsterdam) giving an online @gdch.de lecture organized by the Liebig-Vereinigung.
#ChemSky

Details and registration: gdch.app/event/from-b...

✨The Dream Reactions Symposium has begun! ✨

Today at the castle in Münster, brilliant scientists have gathered to share groundbreaking ideas in chemistry, sustainability, and innovation. 🌍⚗️

A huge thank you to our speakers —let’s make this symposium unforgettable!

#DreamReactions #Sustainability

Dream Reactions Symposium – Wrap-Up Part I ✨

Our speakers are truly passionate about driving towards a positive change! 🌍

Special congratulations to @fragrisoni.bsky.social, the very first recipient of the Green Dream Reactions Award!! 🏆👏

#DreamReactions#Sustainability

Tech-Enhanced Synthesis: Exploring the Synergy between Organic Chemistry and Technology Recent years have witnessed growing interest in integrating enabling technologies into synthetic organic chemistry to address long-standing challenges in reproducibility, sustainability, and scalability. This perspective showcases how modern tools, ranging from continuous-flow reactors and electrochemical cells to photochemical technologies, biocatalysis, mechanochemistry, and self-driving laboratories, are reshaping the way chemists design, perform, and optimize reactions. Through selected case studies, we highlight how these technologies not only solve specific reactivity and process issues but also open new avenues for reactivity discovery and chemical innovation. Rather than viewing technology as a complication, we advocate for its adoption as a natural extension of synthetic creativity, capable of enhancing safety, reducing waste, and expanding accessible chemical space. Our aim is to inspire broader implementation and interdisciplinary training to equip the next generation of chemists with the tools to rethink how synthesis is performed in the 21st century.

Our group’s mission: exploring the synergy between organic chemistry & technology.

In our new @jacs.acspublications.org Perspective, we highlight 6 technologies reshaping synthetic organic chemistry:

⚙️ Flow
💡 Photo
⚡ Electro
🌱 Bio
🌀 Mechano
🤖 Automation

👉 doi.org/10.1021/jacs...

For SusPharma, sustainability is not a single task — it’s the foundation of every process, reaction and solution across the project.
#SustainableByDesign #SusPharma

Tech-Enhanced Synthesis: Exploring the Synergy between Organic Chemistry and Technology Recent years have witnessed growing interest in integrating enabling technologies into synthetic organic chemistry to address long-standing challenges in reproducibility, sustainability, and scalability. This perspective showcases how modern tools, ranging from continuous-flow reactors and electrochemical cells to photochemical technologies, biocatalysis, mechanochemistry, and self-driving laboratories, are reshaping the way chemists design, perform, and optimize reactions. Through selected case studies, we highlight how these technologies not only solve specific reactivity and process issues but also open new avenues for reactivity discovery and chemical innovation. Rather than viewing technology as a complication, we advocate for its adoption as a natural extension of synthetic creativity, capable of enhancing safety, reducing waste, and expanding accessible chemical space. Our aim is to inspire broader implementation and interdisciplinary training to equip the next generation of chemists with the tools to rethink how synthesis is performed in the 21st century.

Our group’s mission: exploring the synergy between organic chemistry & technology.

In our new @jacs.acspublications.org Perspective, we highlight 6 technologies reshaping synthetic organic chemistry:

⚙️ Flow
💡 Photo
⚡ Electro
🌱 Bio
🌀 Mechano
🤖 Automation

👉 doi.org/10.1021/jacs...

We Will do that after final version is Published. Working on that, paper is submitted now 🍀

A Flexible and Affordable Self-Driving Laboratory for Automated Reaction Optimization Self-driving laboratories (SDLs) have the potential to revolutionize chemical discovery and optimization, yet their widespread adoption remains limited by high costs, complex infrastructure, and limited accessibility. Here, we introduce RoboChem-Flex, a low-cost, modular self-driving laboratory platform designed to democratize autonomous chemical experimentation. The system combines customizable, in-house-built hardware with a flexible Python-based software framework that integrates real-time device control and advanced Bayesian optimization strategies, including multi-objective and transfer learning workflows. RoboChem-Flex supports both fully autonomous closed-loop operation and human-in-the-loop configurations, enabling seamless integration with shared analytical equipment and minimizing entry barriers. We validate the versatility of the platform across six diverse case studies, including photocatalysis, biocatalysis, thermal cross-couplings, and enantioselective catalysis, spanning both single and multi-objective optimizations. Through these campaigns, we demonstrate RoboChem-Flex’s ability to navigate large, complex chemical spaces, autonomously identify scalable high-performance reaction conditions, and flexibly adapt to a variety of analytical setups. By providing an affordable, scalable, and open platform, RoboChem-Flex offers a tangible step toward making SDLs accessible to resource-limited laboratories, fostering broader participation in automated chemical research.

#RobSelects preprint of the week #ChemRxiv: A frugal flow-based self-driving laboratory platform for optimization of diverse organic reactions. #autochem https://doi.org/10.26434/chemrxiv-2025-73xqf