Victoria Cornelius

After 14 Critical Care Reviews Meetings we have loads of great talks on file.

Check out this super panel discussion from CCR23 on "Causality".

Get a coffee, sit back, and enjoy!

https://criticalcarereviews.com/meetings/ccr23#Causality

Powered for a 2.5% mortality difference, found point estimate 0.7%
Is aligned with MEGA-ROX (powered for a 1.5% - in progress)
Meanwhile there is much to unpick in discussion here at #CCR25 for these results …
Including overly pragmatic collection of safety outcome ?
3/3

Conservative Oxygen Therapy With Mechanical Ventilation This randomized clinical trial assesses whether reducing supplemental oxygen to a peripheral oxygen saturation target of 90% would reduce mortality among critically ill adults receiving mechanical ven...

Results don’t find evidence for a difference.. paper live
2/3

shorturl.at/uVe6L

Day 2 at #CCR25 & #UKROX
Is conservative O2 therapy in MV in ICU patients beneficial?
Ambitious #NIHR data-enabled trial & great example of how to do this.
3 data sources used for 16,500 patients in 97 sites with enhanced data for 15% for adherence
Great cast list!
1/3

Though combining the design with the primary outcome distribution would bring the heebie-jeebies to most statisticians- they managed it.

Lovely example of ICEMAN for subgroups and reported in full in supp 3
2/2

Augmented Enteral Protein During Critical Illness This randomized clinical trial examines whether augmenting enteral protein increases days alive and free from hospitalization in critically ill patients.

First day at #CCR25 (and already loving it) and the first trial result for
#TARGETproteintrial

No clear clinical conclusions here but a fantastic example of a statically efficient cluster trial design with double crossover. 1/2

jamanetwork.com/journals/jam...

#CCR25 … here we go! Three days of deep discussion of the top trials in critical care. If you are not in the room, do connect via livestream - see criticalcarereviews.com

This week saw the publication of the accompanying editorial from Rachel Phillips and Victoria Cornelius providing a really useful overview of learning from the series 3/7
@vcornelius.bsky.social
@rachpips.bsky.social
trialsjournal.biomedcentral.com/articles/10....

Exploring the effect of COVID-19 restrictions on the social functioning scale in a clinical trial of antipsychotic reduction: using multiple imputation to target a hypothetical estimand is out in @jclinepi.bsky.social www.sciencedirect.com/science/arti... 1/n

Many thanks to you Darren, fabulous couple of days and can feel some momentum building..exciting time ahead :)

Description Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

New opportunity in Imperial CTU for a Lecturer in Digital Health & Clinical Trials. Its all about data-enabled and decentralised trials. Seeking an experienced methodologist who is looking for a new leadership and research role. Details
shorturl.at/IioXW
Closing 5th May

Exploring the effect of COVID-19 restrictions on the Social Functioning Scale in a clinical trial of Antipsychotic Reduction: using multiple imputation to target a hypothetical estimand Many trials are affected by unforeseen events after recruitment has commenced. The aim of this study is to explore a hypothetical strategy for dealing…

📢New publication: Exploring the effect of COVID19 on the Social Functioning Scale in a Antipsychotic Reduction trial using multiple imputation to target a hypothetical estimand by @proflouisemarston.bsky.social @suziecro.bsky.social @vcornelius.bsky.social et al www.sciencedirect.com/science/arti...

More or Less - How did lockdown impact children? - BBC Sounds Five years on, Tim Harford looks at the data on the effect of lockdown.

It was a pleasure to speak to BBC More or Less about the impact of the COVID-19 pandemic on children

An impact felt overwhelmingly from the impact of interventions to suppress the pandemic, rather than from the virus itself

So pleased you coming Ali, should be a great day. and look forward to meeting you in person.

2nd Contemporary Clinical Trials Methodology Meeting Putting contemporary clinical trials methodology into practice. Do you work in clinical trials and want to find out about the latest in the design and delivery of contemporary trials? Join us for ses...

Just registered for the Contemporary Clinical Trials Methodology Meeting in April!

Looking forward to hearing from @suziecro.bsky.social & @vcornelius.bsky.social (and seeing them in person!)

Book here if you think it sounds good (or want to meet me for coffee☕)

www.imperial.ac.uk/events/18598...

With guest speakers: Tony Gordon, Fiona Lugg-Widger, Janis Best-Lane, Lindsey Masters, Cheryl Pugh, Andy King, David Murray, Marion Mafham

Hope to see many colleagues there
4/4

Day 2 will suit trial managers, data managers & trialists wanting to explore operations & DM considerations for
- Platform trials
- Routine data enabled trials
With guest speakers ...3/4

Day 1 will suit statisticians & statistically minded trialists. We will be delving into practical design and analysis considerations for:
MAMS
Platform
& Target trial emulation

With guest speakers: Max Parmar, Stuart Pocock, James Wason, Philip Pallmann, Shaun Seaman, Li Su 2/4

2nd Contemporary Clinical Trials Methodology Meeting Putting contemporary clinical trials methodology into practice. Do you work in clinical trials and want to find out about the latest in the design and delivery of contemporary trials? Join us for ses...

Delighted to announce that registration is now live for our 2-day (and 2nd!) ICTU & RSS Contemporary Clinical Trials meeting for applied trialists.
'Putting Contemporary Clinical Trials into Practice'
2-3 April 2025
10.00 - 16.00
South Kensington, London
shorturl.at/WKhB7 1/4
retweets appreciated

The second trial result for #CCR25 in Titanic Belfast
in June is GASTROSAM

Gastroenteritis Rehydration of African Children with Severe Acute Malnutrition

Join us in June for the best critical care trials in the world

Register at criticalcarereviews.com/meetings/ccr25

Yes it does for PCT but no evidence for CRP to reduce antibiotic duration.
Fantastic editorial by @marionkcampbell.bsky.social to critique methods used and provide perspective on interpretation of secondary analysis explored regarding the strength of the PCT intervention

First up at #ccrdownunder24 ADAPTSepsis with Paul Dark Biomarker guided antibiotic duration in hospitalised patients with sepsis.
Does treatment protocol using CRP or PCT reduce total 28day use of antibiotics- and safely (28day mortality)?

All set for inaugural #ccrdownunder
4 major trial results coming up…

Arrived Melbourne and so excited for #CCRdownunder with some amazing trials and reviews ahead.
Always enjoy the in depth analysis and conversations unique to @criticalcarereviews.com

NIHR Research Support Service Imperial College London and Partners Hub: Meet our advisors As part of the first anniversary celebrations for our service, we asked some of our advisors: what has been your highlight this year? Hear from Professor Greta Rait, Thomas Hamborg, Jane Wilcock, Lorna Hazell, Dr Amelia Cossart and Jack Elkes about what they have enjoyed most about their work as research support advisors. From working with our fantastic team of highly skilled advisors, to supporting with fellowship interviews, and being able to provide advice alongside the clients' research career progression. We're proud of the first year of Imperial College London & Partners Research Support Service, and the hard work of our dedicated team!

Proud to be leading NIHR Imperial College London & Partners Research Support Service with @vcornelius.bsky.social and a fantastic team. We've now been running for one year! And supporting those new to research to research experts. Our advisors share their highlights bit.ly/3VnS1PT @nihr.bsky.social

📅SAVE THE DATE(s) & spread the word about the ***2nd Contemporary Clinical Trials Methodology Meeting*** from ICTU & NIHR RSS Imperial and partners hub, 2nd & 3rd April 2025. Register interest here: bit.ly/3Zg7yUn More details with booking link coming soon!