Previously unknown contacts between mitochondria identified using new approach with AI & volumetric electron microscopy

📹 Benjamin S. Padman, Runa S.J. Lindblom & @lazaroulab.bsky.social, @monashuniversity.bsky.social @jcb.org

➡️ bpod.org.uk/archive/2025/10/3 with
@antdlewis.bsky.social

Solomon R. Guggenheim Museum, New York © 2016 Artists Rights Society (ARS), New York/ADAGP, Paris

Years of Fear by Matta, 1941 #artbots #guggenheim
https://botfrens.com/collections/212/contents/137917

Nike co-founder Phil Knight and wife pledge record $2B to Oregon cancer center, university says An Oregon university says Nike co-founder Phil Knight and his wife Penny Knight have pledged a record $2 billion to its cancer center.

Nike co-founder Phil Knight and his wife Penny Knight have pledged to donate $2 billion to Oregon Health & Science University’s Knight Cancer Institute, the school announced Thursday, describing it as the largest single gift to a U.S. university.
apnews.com/article/ohsu...

#TubulinTuesday!

A stars massive outburst captured by the Hubble Space Telescope.

Credit: NASA/ESA

Proud to share our first lab pre-print: “SND3 is the membrane insertase within a fungal multipass translocon” where @tzujingyang.bsky.social solved the structure of a ribosome-associated SND3-translocon complex involved in ER membrane protein insertion ➡️ doi.org/10.1101/2025...

Chemicals from turmeric and rhubarb could help fight antibiotic-resistant bacteria lurking in wastewater When people take antibiotics, some of the dose is excreted with urine and feces and ends up in our wastewater. The presence of this low dose of antibiotic creates an opportunity for resistant bacteria to evolve.

Natural compounds from turmeric and rhubarb have demonstrated potential to inhibit multidrug-resistant bacteria in wastewater, suggesting a possible strategy to address antibiotic resistance.

Critically endangered leopard caught on camera in Bangladesh forest: "Extremely rare and secretive species" The predator was once widely seen in forested areas. Habitat loss, lack of prey and poaching are key contributors to the loss of leopards, experts say.

Critically endangered leopard caught on camera in Bangladesh forest: "Extremely rare and secretive species" cbsn.ws/4esfOX1

Top: Schematic of GP2 filaments, with labeled residue ranges of ZP domains and four N-glycosylation sites. Middle left: Cryo-EM map of GP2 filaments, color-coded according to the schematic above. The density of one of the flexible branches was indicated by a black arrow. Middle right: Atomic model of GP2 filaments, with five N-glycosylation sites marked by arrows. Bottom: Proposed model of GP2 filaments’ function in the digestive tract. The filament core of UMOD and GP2 is colored in dark blue and green, respectively. The EGF domains and D8C/D10C domains in the branches of both proteins are shown in grey and light blue, respectively. High-mannose N-glycans are colored in red. UPEC cells and their adhesive pilus are colored in pink, while the proteases (such as elastase) are colored in yellow.

#Glycoprotein 2 (GP2) filaments protect against infections by acting as decoys for the bacterial #lectin FimH. The #cryoEM structure of GP2 filaments provides insights into filament assembly and #antibacterial function in the digestive tract @plosbiology.org 🧪 plos.io/3HP2obF

Solomon R. Guggenheim Museum, New York Gift, Fuller Foundation, Inc., 1976 © 2016 Artists Rights Society (ARS), New York/ADAGP, Paris

Blue Painting by Vasily Kandinsky, 1924 #artbots #guggenheim
https://botfrens.com/collections/212/contents/137152

Isaac Asimov on, "If God is Dead, Everything is Permitted?"

“Dog chases down ambulance that owner is being transported in. When EMS realise, they let the dog in.”

Love this 🥰❤️

#DogSky
#Reddit
r\NextF***ingLevel

Tubulin rings induced by cryptophycin show compacted longitudinal interfaces #TubulinTuesday

"This was an experiment by a kindergarten class. They dropped seeds in the cracks of the sidewalk to see what would happen.
This would help our bees "
via I Love Bees

Isoflurane activates the type 1 ryanodine receptor to induce anesthesia in mice What are the molecular targets of inhaled anesthetics, such as isoflurane? This study reports that isoflurane binds type 1 ryanodine receptor, and determines that genetically disrupting a specific res...

What are the molecular targets of inhaled anesthetics, such as isoflurane? Hideaki Ueda &co @riken-bdr.bsky.social @utokyoofficial.bsky.social report that isoflurane binds type 1 ryanodine receptor, which can be targeted to modulate sensitivity to #anesthesia. 🧪
plos.io/45EsVlx

Cryogenic light microscopy of vitrified samples with Angstrom precision www.biorxiv.org/content/10.1101/2025.05.27.656160v1 #cryoEM

Structure of blood cell-specific tubulin and demonstration of dimer spacing compaction in a single protofilament pubmed.ncbi.nlm.nih.gov/39725029/

How sad!

Towards community-driven visual proteomics! Excited to finally share this large-scale curated & annotated dataset of 1829 high-quality #cryoET tomograms of the little green alga that just keeps giving— Chlamydomonas! 🧪🧶🧬🌾🌊🌍

Preprint📜: www.biorxiv.org/content/10.1...

A short thread🧵👇

Structure of blood cell-specific tubulin and demonstration of dimer spacing compaction in a single protofilament Microtubule (MT) function plasticity originates from its composition of α− and β−tubulin isotypes and the post-translational modifications of both sub…

The cryoEM structure of blood cell-specific tubulin is out! @cryoempapers.bsky.social @pdbeurope.bsky.social @actacrystd.iucr.org

www.sciencedirect.com/science/arti...

‘A place of joy’: why scientists are joining the rush to Bluesky Researchers say the social-media platform — an alternative to X — offers more control over the content they see and the people they engage with.: https://www.nature.com/articles/d41586-024-03784-6

There are already many articles for which there is more attention on Bluesky than on other comparable micro-blogging sites, meaning the academic community and the general public have clearly adopted Bluesky as one of its core places to disseminate and discuss new research.

A Place of Joy.

Today's science fact:

#Fluoride in public drinking water reduces cavities & was one of the greatest health achievements of the 20th century.

This article is a few years old, but worth a read.

www.cbc.ca/news/health/...