Type 2 Immunity & Allergy Lab

Microbial metabolism of food allergens determines the severity of IgE-mediated anaphylaxis @biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...

SMI Member Eduardo Villablanca and colleagues review B cells in inflammatory bowel disease at Immunology Letters:
www.sciencedirect.com/science/arti...

#SMIMemberPaper #MucosalImmunology #Immunology

I’m excited to share a perspective that an incredible group of experts in the B cell field worked on over the past 2 years. The thoughtful conversations resulted in what we hope will be a helpful framework moving forward. An open access link is available below:

urldefense.com/v3/__https:/...

Celia & Elisa participated at #SICAM at isciiisalud.bsky.social. Contrats to Elisa for winning the Best Oral Talk Award (sponsored by Inmunotek) on #Microbial #metabolism of food #allergens drives #IgE-mediated #anaphylaxis. A collaboration with the Caminero Lab at @mcmasteruniversity.bsky.social

An illustration of a man falling out of a piece of paper, with text that says: How an academic betrayal led me to change my authorship practices.

"The day the paper was published should have been a moment of pride. Instead, it felt like a quiet erasure." #ScienceWorkingLife https://scim.ag/4p3eH5g

With deep gratitude, we thank Dr. Marc Jenkins for his decades of leadership, mentorship, and dedication to the Center for Immunology. The foundation he built will guide and inspire us for years to come.

👏Congratulations to Prof. Klaus Rajewsky on receiving the first ever #EFIS Lifetime Achievement Award which recognizes not only his groundbreaking science but also his mentorship of countless young researchers worldwide. We honor his vision, brilliance + generosity.Thank you for inspiring us all.

In Seminars in #Immunology, we comment how #microbes may be central to the developmemt and progression of #food #allergy and #celiac disease, and their therapeutic implications.
doi.org/10.1016/j.sm...

Opening the gateway to food-induced anaphylaxis Cysteinyl leukotrienes are important drivers of the anaphylactic response to ingested food antigens

Cysteinyl leukotrienes are important drivers of the anaphylactic response to ingested food antigens @science.org
Comment: www.science.org/doi/10.1126/...
on @rmedzhitov.bsky.social @stephanieeisen.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...

Is IFN-γ good or bad for the host during helminth infections? IFN-γ function during a type-2 helminth infection remains enigmatic. Westfall et al. found an unexpected role for IFN-γ in limiting tissue damage during intestinal infection by Heligmosomoides polygyr...

Thanks to P’ng Loke and Oyebola Oyesola for highlighting our recent article on immune-stromal interactions in @cp-trendsparasitol.bsky.social!!

IFNg does it all!!

www.cell.com/trends/paras...

Take a look at our feedback 👉👈

www.preprintclub.com/preprint-rev...

Journals Operating Predatory Practices Are Systematically Eroding the Science Ethos: A Gate and Code Strategy to Minimise Their Operating Space and Restore Research Best Practice Scientific research seeks to extend knowledge and understanding, an activity that perhaps more than any other advances society and humanity. In essence, it is the search for truth. But, because it se....

Predatory practices—journals, meetings etc—are spoiling the research landscape and erasing trust in science. But what can be done? Here Timmis et al inspect the phenomenon & propose a few measures to contain and even revert the damage enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...

Lung-resident memory B cells maintain allergic IgE responses in the respiratory tract IgE-expressing B cells fail to form memory B cells (MBCs). Nelson et al. show that inhaled allergen induces the formation of lung-resident MBCs with IgG1+ MBCs class switching to IgE driven by interleukin-4 from lung Th2 cells. Upon rechallenge, these lung-resident lymphocytes generate IgE in the airway independent of IgE in the circulation.

Online now: Lung-resident memory B cells maintain allergic IgE responses in the respiratory tract

Today #preprinthub2’s @alisaiakupova.bsky.social will lead a discussion of this #preprint 🥜🐭🦠

ICYMI by First release - now in print @science.org

Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection.

buff.ly/3DjNQ1e

By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al

Our article "Allergic #inflammation triggers #dyslipidemia via IgG signalling" published in Allergy received the award for "Best Scientific Publication of Young Researchers 2024" at the Princess Hospital Excellent Awards".
doi.org/10.1111/all....

In this @biorxivpreprint.bsky.social @biorxiv-immuno.bsky.social, we show that #oral #bacteria can break down #food #allergens, potentially affecting their systemic absorption, #IgE recognition, and allergic reactions—including #anaphylaxis.
www.biorxiv.org/content/10.1...

Microbial metabolism of food allergens determines the severity of IgE-mediated anaphylaxis https://www.biorxiv.org/content/10.1101/2025.02.17.638013v1

Microbial metabolism of food allergens determines the severity of IgE-mediated anaphylaxis https://www.biorxiv.org/content/10.1101/2025.02.17.638013v1

Anaphylaxis: Spotlight on Inflammation - Editorial in Clinical & Experimental Allergy (Jan 2025 Issue) – By Emilio Nuñez- Borque | Timothy E. Dribin | Pablo Rodriguez Del Rio | Carlos A. Camargo Jr | Vanesa Esteban | George du Toit | Rodrigo Jiménez-Saiz | Mattia Giovannini - https://doi.org/10.1111/cea.14610 Inflammation is the main process underlying anaphylaxis, regardless of the molecular pathway involved in the reaction. The activation of the different molecular pathways involved in the reaction results in the release of pro-inflammatory mediators, which leads to the systemic inflammation underlying symptoms and signs of anaphylaxis. Ig, Immunoglobulin; MRGPRX2, Mas-related G protein-coupled receptor member X2.

Anaphylaxis: Spotlight on Inflammation - Editorial in Clinical & Experimental Allergy (Jan 2025 Issue) – By Emilio Nuñez, Mattia Giovannini et.al. doi.org/10.1111/cea....

Microbiota translocation following intestinal barrier disruption promotes Mincle-mediated training of myeloid progenitors in the bone marrow @cp-immunity.bsky.social
@sancholab.bsky.social
www.cell.com/immunity/ful...

Diacylglycerol kinase zeta dictates CD40-mediated immune synapse formation, mTORC1 signaling and plasma cell fate in B lymphocytes https://www.biorxiv.org/content/10.1101/2025.01.11.632541v1

In this new study, published in Allergy, we show that #IgE can form without first switching through #IgG1. The IgG1 step had minimal impact on allergic response or long-term memory.
#Immunology #Allergy #Therapeutics #Anaphylaxis

📄 Full article: doi.org/10.1111/all....

Allergic Reactivity and Memory Occur Independently of Sequential Switching Through IgG1 Sequential switching through IgG1 is not required to produce IgE with sufficient allergen-binding affinity to cause anaphylaxis against food allergens. Sequential switching through IgG1 does not conf....

Using a food allergy model in mice incapable of class switch recombination to IgG1, the Jordana-Waserman Lab showed that sequential class switching is redundant for the production of anaphylactic IgE and allergic recall responses.
onlinelibrary.wiley.com/doi/10.1111/...
#immunology #Immunosky

Anaphylaxis: Spotlight on Inflammation Click on the article title to read more.

The role of #inflammation has been underlined as central in several atopic #diseases, but, surprisingly, not in #anaphylaxis.
doi.org/10.1111/cea....

Translocation of gut Enterococcus faecalis trains myeloid bone marrow progenitors via the C-type lectin receptor Mincle Impairment of the intestinal barrier allows the systemic translocation of commensal bacteria, inducing a pro-inflammatory state in the host. To address potential mechanisms underlying this link, we ex...

What is the effect of increased bacterial dissemination in distant organs?
Check our www.biorxiv.org/content/10.1...
1 Gut barrier disruption induces trained immunity in bone marrow progenitors
2 Enterococcus faecalis translocates to the bone marrow inducing trained immunity

I would love to join!

Fungal symbiont transmitted by free-living mice promotes type 2 immunity - Nature Kazachstania pintolopesii is a highly prevalent fungal symbiont that can trigger type 2 immunity and influence the composition of the gut mycobiome, as well as immune and disease phenotypes.

Fascinating new paper about how commensal #fungi can promote #type2 responses in mice, a process involving fungal induction of #IL-33 🍄 🧪 #ImmunoSky www.nature.com/articles/s41...

Happy to share our latest paper on T follicular helper cell profiles that distinguish milk allergy from eosinophilic esophagitis

Congratulations to Dr. Emilio Nuñez-Borque on delivering an invited talk at #SEAIC2024 about #extracellular #vesicles and #microRNAs in #anaphylaxis!