π Congratulations to Luis Rodriguez @lurod8.bsky.social on leading this research on how impaired AMPK control of alveolar epithelial cell metabolism promotes pulmonary fibrosis. Check out the new manuscript from the Beers lab @westphillytough.bsky.social
insight.jci.org/articles/vie...
17.07.2025 12:21 β π 1 π 1 π¬ 0 π 0
REGULATORY T CELLS PROTECT AGAINST ABERRANT REMODELING IN A MOUSE MODEL OF PULMONARY FIBROSIS
Regulatory T (Treg) cells are well recognized for their role in immune regulation; however, their role in tissue regeneration is not fully understood. This study demonstrates such a role of Tregs in a published preclinical murine model of spontaneous pulmonary fibrosis (PF) expressing a human PF related mutation in the Surfactant Protein-C (SP-C) gene (SFTPCI73T). Genetic crosses of SP-CI73T mice with Foxp3GFP and Foxp3DTR lines were utilized to study Treg behavior during PF development. We found that FoxP3+Tregs accumulate during the transition from inflammation to fibrogenesis, peaking at 21-28 days after mutant SftpcI73T induction localizing to both perivascular and distal fibrotic lung regions. Diphtheria toxin mediated ablation of Tregs at 17 days worsened fibrosis and increased levels of TGFΞ² and inflammatory cytokines. Tregs expressed Th2 markers (Gata3+) and elaborated factors including amphiregulin (Areg) and Osteopontin (Spp1). Reductionist experiments showed that lung Tregs enhanced organoid formation when co-cultured with alveolar epithelial cells and adventitial fibroblasts, an effect size mimicked using Areg and Spp1 in combination. Our findings demonstrate that immune-mesenchymal-epithelial signaling crosstalk is present in the distal lung wherein Tregs play a protective role by limiting fibrosis and promoting tissue repair, highlighting their broader function beyond immune modulation in lung injury. ### Competing Interest Statement The authors have declared no competing interest. National Institutes of Health, https://ror.org/01cwqze88, 1R01HL145408, HL152970, HL007586, HL150226, 1K99HL171946
Check out the newest preprint from
the @westphillytough.bsky.social lead by @amurthy10.bsky.social exploring the important role of Regulatory T cells as modulators of fibrotic resolution! www.biorxiv.org/content/10.1...
06.07.2025 16:23 β π 1 π 1 π¬ 0 π 0
Postdocs and Research Associates in Psychiatry are ready for their union! Let's go!!!! πͺπͺπͺ
16.07.2025 17:48 β π 1 π 1 π¬ 0 π 0
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