@jci-insight.bsky.social
High-quality, topflight, and clinically impactful basic and translational research representative of all biomedical specialties and physician-scientists: https://insight.jci.org/
Temporal lobe epilepsy affects ~50 million people globally
@brennan-lab-ucd.bsky.social @futureneuro.bsky.social & team link altered RNA methylation to changes in protein expression, neuronal structure, and seizure susceptibility across models: buff.ly/xcHntUK
ICYMI: Some children with malnutrition disorders don’t respond to nutritional interventions—
Sean R. Moore & team now identify gut microbial signatures and biomarkers associated with the response to ready-to-use supplemental in acute childhood malnutrition: buff.ly/SVHqgJs
Send your submissions | Special Issue on Fibrosis!
JCI Insight invites your papers for consideration in a special issue focused on all aspects of fibrosis.
Submission deadline: October 31, 2025
Scientific editors: Gavin E. Arteel and Melanie Königshoff
buff.ly/O4AqgvZ
ICYMI: Treatment-resistant prostate cancer remains a barrier to optimizing patient outcomes.
Donald W. Kufe & team @danafarber.bsky.social now report on MUC1-C as a driver of resistance, and develop a targeted antibody that decreases tumor volume in mouse models.
See more:
Slow the (neutrophil) roll in lung infections—
Alexander Zarbock & team identify Csk as key to dampening neutrophil infiltration during K. pneumoniae infection in mice: buff.ly/EkrsZJ1
More than 1 in 4 men will develop an inguinal hernia during their life for which non-surgical treatments remain unavailable.
Serdar E. Bulun & team now show antagonism of progesterone reduced hernia size or prevented its formation in mouse models: buff.ly/TGfbAZL
Read the JCI insight article: insight.jci.org/articles/vie...
01.08.2025 14:05 — 👍 0 🔁 0 💬 0 📌 0
Check out our top read article this month 👇
Human pegivirus alters brain and blood immune and transcriptomic profiles of patients with Parkinson’s disease: buff.ly/yQApFEY
@igorkoralnik.bsky.social & team
Behind the scenes: Dr. Avishek Roy analyzes mouse tissue histology and staining to determine the underlying defect of a congenital disorder of glycosylation in Mpi-deficient mice.
31.07.2025 16:08 — 👍 1 🔁 0 💬 0 📌 0
A breakthrough for the study of N-glycosylation in vivo!
Jeffrey A. SoRelle & team debuts a mouse model for mannose phosphate isomerase deficiency, a congenital disorder of glycosylation.
Full article: buff.ly/KAlNQ3O
Diabetic kidney disease leads to glomerular alterations including foot process effacement, but the precise mechanism is unclear.
Roberto Boi & team now show the cytoskeletal protein CKAP4 is important for foot process architecture and is reduced in DKD: buff.ly/OWUJx2T
Hypoxia-inducible factor stabilizers lead to red blood cell production and are typically used in the treatment of chronic kidney disease.
Holger K. Eltzschig & team now evaluate vadadustat in mice and people with SARS-CoV-2-associated lung injury: buff.ly/GCasWYt
Treatment-resistant prostate cancer remains a barrier to optimizing patient outcomes.
Donald W. Kufe & team @danafarber.bsky.social now report on MUC1-C as a driver of resistance, and develop a targeted antibody that decreases tumor volume in mouse models.
See more: buff.ly/TdXLSJa
ICYMI:
Set your sights on this!
This issue’s cover features work by @stemcellseh.bsky.social & team on an inexpensive, clinically translatable photoreceptor isolation strategy for the production of cell therapies to treat inherited blindness: buff.ly/DOm5lN5
Some children with malnutrition disorders don’t respond to nutritional interventions—
Sean R. Moore & team @cincychildrens.bsky.social now identify gut microbial signatures and biomarkers associated with the response to ready-to-use supplemental in acute childhood malnutrition: buff.ly/mlMKBkp
ICYMI:
Despite treatments for multiple sclerosis, halting progression remains an unmet need.
Charles L. Howe & team discover inhibition of the pentose phosphate pathway in autoimmune CD8+ T cells reduces their neurotoxic effects in demyelinating disease models: buff.ly/nC65AzR
In melanoma, obesity is linked with a better immunotherapy response
Carole Bourquin & team now implicate estrogen with increasing the antitumor immune response, & suggest estrogen levels indicate ICI response in overweight and obese men with melanoma: buff.ly/egF7xKn
No small potatoes!
Martin E. Fernandez-Zapico & team identify the nuclear envelope protein Emerin as a regulator of nuclear size in KRAS-driven pancreatic cancer.
Complete report: buff.ly/G9cZcBQ
CAR-T cell therapy for solid tumors remains limited.
In this Review, Ruoqi Chen et al. discuss the latest advances in transcriptional factor engineering for empowering CAR-T cells with superior antitumor efficacy.
buff.ly/mVtMP96
Despite treatments for multiple sclerosis, halting progression remains an unmet need.
Charles L. Howe & team discover inhibition of the pentose phosphate pathway in autoimmune CD8+ T cells reduces their neurotoxic effects in demyelinating disease models: buff.ly/qxb4T5N
Happy to share our new work @jci-insight.bsky.social insight.jci.org/articles/vie... When I was pregnant in Dec 2020, one of the many things that concerned me was if the COVID-19 vaccine would protect me as well as non-pregnant people, as I knew the high risk of COVID-19 infection in pregnancy (1/n)
22.07.2025 17:15 — 👍 3 🔁 2 💬 1 📌 0🚨 NEW PUBLICATION 🚨 "Pregnancy and lactation induce distinct immune responses to COVID-19 booster vaccination and SARS-CoV-2 breakthrough infection" from the Roan Lab in @jci-insight.bsky.social
23.07.2025 14:08 — 👍 1 🔁 2 💬 0 📌 0
Set your sights on this!
This issue’s cover features work by @stemcellseh.bsky.social & team on an inexpensive, clinically translatable photoreceptor isolation strategy for the production of cell therapies to treat inherited blindness: buff.ly/Jr2m8iN
Immune therapy in cancer is often limited by adverse effects including autoimmune diabetes.
Melissa G. Lechner & team discover the JAK inhibitor ruxolitinib is protective against ICI-T1DM: buff.ly/FnqAtF8
Tapping natural killer cells with N-803 as part of the cure strategy in HIV?
Timothy W. Schacker & team evaluate lymph nodes from ART-suppressed people with HIV after treatment with N-803 in a phase IB clinical trial.
Full report: buff.ly/C6ka7yf
Read the manuscript in @jci-insight.bsky.social : insight.jci.org/articles/vie...
21.07.2025 13:54 — 👍 3 🔁 1 💬 0 📌 0
The visual summary 👇
20.07.2025 18:01 — 👍 0 🔁 0 💬 0 📌 0
ICYMI:
Uncovering infectious agents often missed by conventional diagnostic testing for meningoencephalitis—
Antonio C. da Costa & team identify diverse pathogens using metagenomic sequencing: buff.ly/SIzepsI
Proliferative arterial disease is characterized by thickened arterial walls due to smooth muscle cells, but targets that prevent proliferative activity remain unestablished
Hanyan Yang & team now discover NEXN mediates vascular remodeling via ER stress: buff.ly/J46U07u
ICYMI: Parsing the STING in pulmonary hypertension—
Andrew J. Bryant & team report on opposing roles for STING in PH—a paradigm shifting mechanism suggesting we refocus on treatments that target cell-specific inflammatory activation: buff.ly/DWmLPLp
