Joseph Genereux

Keep an eye out for this rising star on the faculty job market. Elizabeth is truly remarkable. Her resilience and determination continue to inspire me, especially in the face of setbacks during these times. #proudMOSAICcoach

"The Committee... maintains its longstanding bill language prohibiting NIH from developing or implementing a modified approach to funding F&A costs" on p. 156 is encouraging.

Isn't this the same as saying that the optimal trypsin concentration is 10 ng/µL, irrespective of the amount of protein?

Harvey Mudd is hiring a tenure track analytical chemist. Come join my department!

Great new Hrd1 complex structure from Leo Lin with the Qi and Jomaa labs at UVA. Lots of interesting features, including that the functional form is the dimer. Congratulations Leo!

N-glycan-dependent protein maturation and quality control in the ER - Nature Reviews Molecular Cell Biology N-glycosylation of secretory pathway proteins in the ER is crucial for their maturation and quality control. Recent insights into the enzymes and chaperones that facilitate N-glycosylation have expand...

Dan, a friend for many of us, passed at the end of last year. Before leaving, with his students and colleagues, he prepared this gift. Amazing.
N-glycan-dependent protein maturation and quality control in the ER | Nature Reviews Molecular Cell Biology
www.nature.com/articles/s41...

Contrary to Clear, Verifiable Facts, Secretary Kennedy Continues to Repeat Harmful Myths About Alzheimer’s and Dementia Research The Alzheimer's Association calls on HHS Secretary Kennedy to stop dangerous fabrications about the state of Alzheimer’s and dementia research.

www.alz.org/news/2025/ke...

To be clear, if this bill passes, it will end all scientific research & medical training in the US. It will close hospitals. It will be economically devastating. Millions will lose their jobs.

Call your representatives & tell them to vote fuck no on 15% IDC rates & the rest of this horror show.

I often evaluate how I spend my time and emotional energy, and how it matches my values. I care about the scientific goals, the people (trainees, students, colleagues, and friends), and the joy of discovery and benchwork. All the rest is just to make sure that I can keep doing the parts that matter.

The PhET Interactive Simulations (app and website) are fantastic. I highly recommend them. My kid particularly enjoys the circuit builder and gene expression simulations. PhET is a great resource, and it's terrible that its National Science Foundation (NSF) grant was cancelled.

Blunt letter to the editor on ACS: "If ACS won’t stand up now, it should stand down." cen.acs.org/business/Rea... #chemsky 🧪⚗️

ByeTAC: Bypassing E-Ligase-Targeting Chimeras for Direct Proteasome Degradation The development of targeted protein degradation by recruiting a protein of interest to a ubiquitin ligase to facilitate its degradation has become a powerful therapeutic tool. The potential of this approach is limited to proteins that can be readily ubiquitinated and relies on having a ligand with the various E3 ligases. Here, we describe a new methodology for targeted protein degradation that directly recruits a protein of interest to the proteasome for degradation. We generated bifunctional molecules that incorporate a small molecule ligand into a subunit on the 26S proteasome that recruits the protein directly for degradation. ByeTAC degradation requires binding to Rpn-13, a nonessential ubiquitin receptor of the 26S proteasome, and the protein of interest and does not have to rely on the E ligase cascade for ubiquitination. The ByeTAC methodology demonstrates the application of directly recruiting a protein to the proteasome via interactions with Rpn-13 for degradation.

ByeTACs is finally out in J. Med Chem. Congrats team! Can't wait to see how else we can use this degradation technology. @codyloy.bsky.social

pubs.acs.org/doi/10.1021/...

During RESET, misfolded GPI-APs traffic from the ER to the Golgi. Top left : Time-lapse imaging sequence collected immediately after thapsigargin (TG) treatment of a typical YFP-PrP * NRK cell that was co-expressing ER-marker, Cerulean-calnexin (CER-CNX). Scale bar represents 10 µm. Top right: Plot of the average Pearson’s r values between YFP-PrP * and CER-CNX for 9 individual cells across the 0 and 20 min time points of time-lapses collected after addition of TG. Bottom left: Time-lapse imaging sequence collected immediately after TG-treatment of a typical YFP-PrP * NRK cell that was co-expressing the Golgi marker, CER-GalT. Scale bar represents 10 µm. Bottom right: Plot of the average Pearson’s r values between YFP-PrP * and CER-GalT for 10 individual cells across the 0 and 20 min time points of time-lapses collected after addition of TG.

TMED9 mediates export of misfolded #prion proteins from the ER. @pskcellbio.bsky.social &co show that TMED9 also helps capture #misfolded GPI-anchored proteins that are released by calnexin in the ER and moved into the Golgi for degradation via the RESET pathway @plosbiology.org 🧪 plos.io/44kURu5

Congratulations Danielle!

Plasticity of the mammalian integrated stress response Nature - A study describes the split integrated stress response, a cellular stress response mechanism characterized by reduced eIF2B activity without eIF2α phosphorylation, which activates the...

Beautiful work by my colleague and friend Maria Hatzoglou 🎉

rdcu.be/efdpL

Bukele’s justice minister has said that those held would never return to their communities.

If 250 people can be deported to a concentration camp in El Salvador without due process and vanished forever, then you can be deported to a concentration camp in El Salvador without due process and vanished forever.

apnews.com/article/el-s...

Assistant Teaching Professor - HigherEdJobs Jobs in higher education. Faculty and administrative positions at colleges and universities. Updated daily. Free to job seekers.

Come be our colleague!

Interested in careers @ PUI or R2? We envision this 3yr position to be launching pad for such roles. Teaching & research. Modest start-up. Mentoring, other resources.

Great for graduating PhD students, current PDs.

Please share!

www.higheredjobs.com/search/detai...

Poster for FASEB Endoplasmic Reticulum 2025 Conference to be held 8-12 June 2025 in Melbourne, Florida. The poster includes the invited speakers

We have a lineup of outstanding speakers 😍 for this year’s conference 👇. Please share the poster with your network to spread the word 📢!

I haven't been happy with how I introduce rate-determining steps in my intro chem classes on kinetics. Today I sang Sam Cooke's "Another Saturday Night" in class, and the students got the concept: meeting girls is the rate-determining step when his charisma guarantees a date will follow.

One of the most significant and challenging projects of my career so far. PepCentric: a scalable computational platform utilizing novel 2-D fragment indexing for rapid peptide-centric searches, enabling proteogenomics searches against billions of spectra in seconds. www.biorxiv.org/content/10.1...

Okay, nerds, buckle in!
It's time for some SCIENCE.

Back in the late 1960s, a scientist got some government funding from the National Science Foundation (NSF) and the Atomic Energy Commission to look for interesting bacteria living in extreme environments.

1/x

@standupforscience.bsky.social Los Angeles 3/7 noon at the Federal building docs.google.com/forms/d/e/1F...

Graduate Reductions Across Biomedical Sciences (2025)

I created a brief spreadsheet of reductions I've heard of so far. Any additions you know of (especially if you have the links/receipts) would be great: docs.google.com/spreadsheets...

As others have noted, the life of Carl Bosch is worth a look in these times. Fritz Haber demonstrated that nitrogen could be reduced to ammonia, but Bosch’s work turned that into a technology that changed the world with sudden new supplies of fertilizer (and of explosives). (1/8)

Stand Up And Be Counted

Biopharma companies and CEOs are keeping their heads down at their own peril. They should speak up about what’s happening to the NIH and other science agencies before it’s too late.

Silence gives consent. And no one should consent to this.

Concerned about the devastating effect of the cut to NIH indirect costs (from >60% at many to 15% for all) on US biomedical research that takes effect tomorrow? Phone the Committee on Health, Education, Labor, and Pensions (HELP), Chaired by Senator Bill Cassidy TOMORROW morning at 202-224-6770.

YouTube video by Association of American Universities Facilities and Administrative (F&A) Costs Explainer

Great summary on what are NIH F&A (IDC) and why it is critical to maintain the rate for research. Innovation has been leading this country for decades. Let’s try to keep it that way ! 👉🏻👉🏻 m.youtube.com/watch?v=yxTD...

ATTENTION

If you are someone who had an F31-Diversity (or similar) application submitted this cycle, please DM me here, contact me on signal (jeremymberg.78), or email me at jeremymberg@gmail.com.

I will keep all information confidential.

2/n

The expanded feasibility and ease of noncanonical amino acid incorporation over the past decade has expanded what chemical biologists can dream, and it's great to see those frontiers pushed back even further! Congratulations Abhishek!

Student coauthors of this paper.

List of all students in the Cell Biology course who contributed to the project

Excited to share our latest work!

We found kinesin Kar3 is required for ER protein quality control.

This 10-yr project involved 78 students, including undergrad & master's students in my lab & students enrolled in CURE I helped design, & 2 excellent colleagues.

www.molbiolcell.org/doi/10.1091/...