Cláudio Gomes Lab - Protein Misfolding in Disease

Frontiers | Neuronal expression of S100B triggered by oligomeric Aβ peptide contributes to protection against cytoskeletal damage and synaptic loss Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by the intracellular deposition of Tau protein and extracellular deposition of...

📣 In Alzheimer’s disease neurons respond to toxic Aβ oligomers by boosting S100B — a Ca-binding chaperone that protects the cytoskeleton and synapses from damage 🧠Collaboration with the Cardoso Lab, spearheaded by our joint PhD student Joana Saavedra 👩‍🔬👏

📄https://doi.org/10.3389/fnmol.2025.1636365

Design of intrinsically disordered region binding proteins Intrinsically disordered proteins and peptides play key roles in biology, but a lack of defined structures and high variability in sequence and conformational preferences have made targeting such syst...

Design of intrinsically disordered region binding proteins | Science www.science.org/doi/10.1126/...

The second day of talks at #ISPIS2025 #Lisbon finishes with one of our hosts, @claudiogomeslab.bsky.social, telling us about extracellular proteostasis, and the role of S100B as a chaperone holdase in biology and disease

International Symposium on Protein Interactions and self assembly 🇵🇹
📣 Day 2 quick off with @lindorfflarsen.bsky.social talk on Predicting condensates of disordered proteins and many others to follow, poster pitches and session and lakeside lunch. #ISPIS2025 #Lisbon @cienciasulisboa.bsky.social

All set for the start of the 'International Symposium on Protein interactions and self assembly' in Lisbon 🇵🇹 later today. Excited to host an amazing lineup of speakers and 65 participants from all over during the next 3 days #ISPIS2025 @twin2pipsa @cienciasulisboa.bsky.social #ULisboa

Received the 2025 ULisboa/CGD Award in Biomedical Sciences yesterday! 🧪🧠🥼
Thank you to my incredible team and collaborators — and congrats to all fellow awardees!👏

Still time to submit an abstract for a short talk! Join us in Lisbon to discuss all things protein — interactions, aggregation, phase separation, and more! 🗓️ Deadline 30 June

📢 International Symposium on Protein Interactions and Self-Assembly

Join us in ☀️ Lisbon 🇵🇹
🗓️ 14–16 July 2025

🗣️ A great programme + short talks selected from abstracts.

🔗 Check it here: twin2pipsa.campus.ciencias.ulisboa.pt/ISPIS2025.html

🔬 Powered by #TWIN2PIPSA at @cienciasulisboa.bsky.social

S100B Mitigates Cytoskeletal and Mitochondrial Alterations in a Glial Cell Model of Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay - Molecular Neurobiology Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS) is an early-onset neurological disorder caused by mutations in the SACS gene, resulting in the loss of sacsin function. Sacsin is a m...

Just out! A collaboration with the Herrera lab shows that S100B acts as a chaperone supporting intermediate filament organization, compensating for sacsin loss in a cell model of Autosomal Recessive Spastic Ataxia of Charlevoix–Saguenay (ARSACS) #molecularneurobiology
doi.org/10.1007/s120...

Congratulations to Guilherme Moreira for the brilliant defence of his PhD thesis: “The calcium-binding protein S100B as a novel chaperone preventing Tau aggregation in Alzheimer’s disease” 🧠 Huge thanks to the jury and everyone who came to support! #ProudSupervisor @cienciasulisboa.bsky.social

Nanopore sequencing set to transform our understanding of proteins Rapid sequencing technique can not only deal with proteins hundreds of amino acids long but can detect modifications

A new protein sequencing method, which uses a biological motor to pull a protein through a tiny nanopore, could revolutionise protein analysis.
www.chemistryworld.c...

Progress in Understanding and Tackling Multifactorial Alzheimer’s Disease - American Chemical Society A virtual symposium of ACS Fall 2025 programmed at convenient day times of multiple regions. This Global Virtual Symposia aims to discuss these recent developments comprehensively, enhancing our unde...

Thrilled to be an invited speaker 🗣️ at the @acs.org Fall 2025
Global Virtual Symposium "Tackling Multifactorial #Alzheimer’s Disease"🧠 .Join us as we explore the latest advances in understanding the complex nature of AD. 📆 Submit your abstract by 31/3/24 🧪
www.acs.org/events/fall/...

Our paper on prediction of phase-separation propensities of disordered proteins from sequence is now published:
www.pnas.org/doi/10.1073/...

The paper has been substantially updated compared to the preprint including new experimental data and using the neural network to finetune CALVADOS. 1/n

Predictomes, a classifier-curated database of AlphaFold-modeled protein-protein interactions Schmid and Walter train a classifier that discerns functionally relevant structure predictions in proteome-wide protein-protein interaction (PPI) screens using AlphaFold-Multimer, and they use this confidence metric to curate a database of 40,000 predicted interactions among ∼300 genome maintenance proteins.

Predictomes, a classifier-curated database of AlphaFold-modeled protein-protein interactions

Looking forward #ADAM10 kick-off 🇸🇪 3 days of all things amyloid and great opportunity to meet old friends and making new ones! Thanks @professorpernilla.bsky.social and Elin Esbjorner et al for such a great program. Reach out if you are around
www.chalmers.se/en/conferenc...

Our reseach combines #biochemistry, biophysics, and cell biology to unravel #ProteinInteractions and self-assembly and how #chaperones influence aggregation, #PhaseSeparation and #proteostasis. The image depicts S100B, a chaperone acting on #Tau and #AmyloidBeta, and one of our favorite models 🧪

Hello Bluesky, we just landed and are happy to reconnect! We research on #proteins and mechanisms of aggregation in #Alzheimer's Disease and #ProteinFolding disorders at ULisboa 🧪 Follow us for news and updates on lab life and achievements 🥼 and check us out at:
🔗 folding.campus.ciencias.ulisboa.pt