LancasterM.bsky.social

Sad to hear of the passing of Jack Daniels. A legend in the field of running coaching. May the wind be ever at your back.

Run fast and furious for longevity: Intensity or volume: the role of physical activity in longevity url:https://academic.oup.com/eurjpc/article/32/1/10/7758152

Global Effect of Cardiovascular Risk Factors on Lifetime Estimates | NEJM Five risk factors account for approximately 50% of the global burden of cardiovascular disease. How the presence or absence of classic risk factors affects lifetime estimates of cardiovascular dise...

Interesting analysis of cardiovascular risk and longevity. Show BMI as the wrong thing to focus on, although the closely-linked issue of BP is a key thing to target if you want to live a long healthy life: www.nejm.org/doi/pdf/10.1...

Muscle-derived small extracellular vesicles induce liver fibrosis during overtraining Liu et al. show that overtraining promotes liver fibrosis. During this process, muscle lactate accumulation facilitates the sorting of FBXO2 into small extracellular vesicles (SEVs) through SORBS3 lac...

There's a concerning impact of overtraining! Muscle-derived small extracellular vesicles induce liver fibrosis during overtraining: Cell Metabolism www.cell.com/cell-metabol...

Cardiac Arrest During Long-Distance Running Races This case series and cohort study uses data from the Race Associated Cardiac Event Registry to determine the incidence and outcomes of cardiac arrest during US marathons and half-marathons between 201...

Long distance races are reassuringly safe, and probably getting safer. Chance of cardiac arrest is super low: 176 out of 29.3 million runners in this study. Most are male and survival chances are good with rapid CPR and defib use: jamanetwork.com/journals/jam...

Optimal dietary patterns for healthy aging - Nature Medicine In two longitudinal cohorts followed for 30 years, the associations of eight different dietary patterns with healthy aging—encompassing cognitive, physical and mental health—were studied, identifying ...

No grand surprises but more evidence a balanced diet with plenty of vegetables helps with healthy ageing: www.nature.com/articles/s41...

How marathons change runners’ brains: scans point to surprise energy source After the gruelling races, levels of the nerve-cell insulator myelin were lower, suggesting the brain uses the fatty substance as fuel.

Are marathons really and ultra endurance events really so taxing you have to digest the lipids out of your brain to keep it fuelled? A rather interesting idea. Does that mean don't expect fast answers to hard questions the day after a marathon....? www.nature.com/articles/d41...

Clinical Considerations for Competitive Sports Participation for Athletes With Cardiovascular Abnormalities: A Scientific Statement From the American Heart Association and American College of Cardiolo... Collaborators: Larry A. Allen, MD, MHS, FAHA, FACC; Mats Börjesson, MD, PhD, FACC; Alan C. Braverman, MD, FACC; Julie A. Brothers, MD; Silvia Castelletti, MD, MSc, FESC; Eugene H. Chung, MD, MPH, FHRS...

New AHA statement on clinical considerations for competitive athletes with cardiovascular abnormalities. Changes generally reflect the developing stance of it may do more good than harm so monitor but keep going: www.ahajournals.org/doi/10.1161/...

Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKα2 signaling Chen et al. demonstrate that circadian-timed activation of adipocyte AMPKα2 signaling by meal timing (day-restricted feeding, DRF, akin to Ramadan-style fasting) or an adipocyte AMPK activator enhance...

Run in the morning to optimise endurance gains? Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKα2 signaling: Cell Metabolism www.cell.com/cell-metabol...

Cardiac Arrhythmia Mechanisms gets underway…..

On my way to the Gordon Research Conference on Cardiac Arrhythmia Mechanisms. Poster made it through airport security ok so first hurdle cleared!

Average v-c pay tops £340,000 as rises outpace rank-and-file Union describes results of THE analysis as ‘sickening’ amid spate of redundancies and course closures in crisis-hit universities

Interesting to see where tops the bill (literally) for their leadership team….. www.timeshighereducation.com/news/average...

Frontiers | The effects of weather on physical activity and sedentary behaviour in older adults

They're a hardy lot in Canada - the weather doesn't seem to impact their physical activity much at all (puts my fair-weather running/cycling to shame): www.frontiersin.org/journals/spo...

Muscle-derived small extracellular vesicles induce liver fibrosis during overtraining Liu et al. show that overtraining promotes liver fibrosis. During this process, muscle lactate accumulation facilitates the sorting of FBXO2 into small extracellular vesicles (SEVs) through SORBS3 lac...

Interesting potential impact of overtraining and fascinating new signaling pathways, to me at least: Muscle-derived small extracellular vesicles induce liver fibrosis during overtraining: Cell Metabolism www.cell.com/cell-metabol...

Review of research funding in the UK recommends reducing research bureaucracy and streamlining funding application processes: assets.publishing.service.gov.uk/media/62e234...

Horizons Institute newsletter February 2024 Connect with us via: Website | LinkedIn | BlueSky | X

Our latest newsletter is now out!

Take a look for more on
👉 our Challenge Theme Networks development programme,
👉 what our current networks are getting up to,
👉 our Global Academy in-person Crucible, and
👉 lots more ways for you to get involved!

#AcademicSky #Interdisciplinary #Research 🧪

Heart Month February 2024 is Heart Month. Go Red or learn CPR to help save lives.

It’s February - Heart month. Surviving a heart attack is highly influenced by very fast aid with CPR, yet less than 50% know how to do this effectively. Learn how to help at: www.bhf.org.uk/how-you-can-...