Dan Johnson

50th EWGCCE Meeting 2026 on ESC 365 Seminar on Cellular Electrophysiology by the WG on Cardiac Cellular Electrophysiology to improve your practice and prepare for your exams.

Abstract submission deadline approaching for the 50th EWGCCE! Join us 6–8 July 2026 in Leuven 🇧🇪 to celebrate 50 years of cardiac cellular electrophysiology. Submit your abstract today (or by 2nd March! 😀)

Looking forward to seeing you there!

#EWGCCE

esc365.escardio.org/event/2035

Selective ROCK2 inhibition reduces microvascular obstruction but does not reduce myocardial infarction after ischaemia and reperfusion Myocardial ischaemia/reperfusion (I/R) injury causes infarction, microvascular obstruction (MVO), and haemorrhage. MVO, often driven by vasospasm, lac…

Stuck between a ROCK2 and a hard place?
New research just out shows selective ROCK2 inhibition reduces microvascular obstruction after myocardial I/R but doesn’t limit infarct size. Highlights distinct roles for ROCK isoforms in #cardioprotection. 🫀

www.sciencedirect.com/science/arti...

#CardioSky

Response of human iPSC-cardiomyocytes to adrenergic drugs assessed by high-throughput pericellular oxygen measurements and computational modeling Rate- and contractility-modulating drugs, such as adrenergic agonists and antagonists, are widely used in the treatment of cardiovascular conditions. …

🫀New research demonstrates that high-throughput, label-free optical oxygen measurements can assess adrenergic effects in iPSC-derived #cardiomyocytes

Paired with all-optical #electrophysiology, this enables scalable, human-based preclinical testing

#CardioSky

www.sciencedirect.com/science/arti...

The #deadline for our special edition of @jphysiol.bsky.social
looking at Crosstalk of cells in the #heart has been extended until March 6th!

Feel free to get in touch or check out the call on the website!

physoc.onlinelibrary.wiley.com/hub/journal/...

@physoc.bsky.social

#CardioSky

Are you working on #cellular #cross-talk in the #heart? Looking for an outlet for your work?

Look no further! Molly O Reillyy, Chris 'O Shea and I are editing an edition of @jphysiol.bsky.social

Deadline 6th Jan!

#CardioSky

physoc.onlinelibrary.wiley.com/hub/journal/...

Final Call!

🫀 Boost your cardiac research career!

Scientific Exchange Grants from the WG Cellular Cardiac Electrophysiology offer €2,500 for a 1-month stay in a European lab. Great chance to learn new skills + collaborate internationally.

Apply by 8 Dec 2025

👉 escardio.org/Research/Res...

Rab10 plays a protective role in the development of pathological cardiac hypertrophy Prolonged cardiac hypertrophy is a main risk factor for heart failure (HF). During cardiac hypertrophy remodelling, there is an increase in protein sy…

Rab10 to the rescue! 🦸‍♂️🫀!

New study from Xu et al. in the December issue shows how this tiny protein helps keep harmful heart growth in check.

Read more at:
www.sciencedirect.com/science/arti...

#CardioProtection #Hypertrophy #CardioSky

Scientific Exchange Grants Your access to the latest cardiovascular news, science, tools and resources.

🚀 Calling all early-career cellular cardiac #electrophysiology researchers!

The @escardio.bsky.social is offering Scientific Exchange Grants for short-term research visits across Europe 🌍.

📅 Deadline: 8 Dec 2025 — don’t miss out!

👉 Learn more & apply:

escardio.org/Research/Res...

#CardioSky

Cardiomyocyte Rac1 signaling in hypertrophy, arrhythmia, and cardiac stress adaptation Cardiovascular disease remains the leading cause of mortality globally and is often marked by pathologic cardiac remodeling including hypertrophy and …

🧪 Just out: a new #review of Rac1-driven signalling in cardiomyocytes — covering #hypertrophy, #arrhythmia and #redox stress.

A must-read for anyone in cardiac research! 💙

#Cardiology #HeartResearch #SignalTransduction #CardioSky

www.sciencedirect.com/science/arti...

Signaling pathway alterations in hearts of a porcine model harboring a β-myosin heavy chain (MYH7-R403Q) gene variant The disease-causing myosin variant (MYH7-403Q) is linked to hypertrophic cardiomyopathy (HCM). We carried out a research study of signaling pathways i…

On your way to #AHA or just looking for some weekend reading?

Check out the latest paper from Warren et al who uncovered region-specific metabolic and signalling changes in the endocardium vs epicardium in a mini-pig model of #HCM 🫀🫀

sciencedirect.com/science/arti...

#CardioSky #AnimalModel

YAP/TAZ deletion in vascular smooth muscle cells mirrors atherosclerosis-associated transcriptional programs The transcriptional co-activators YAP (YAP1) and TAZ (WWTR1) are central regulators of vascular smooth muscle cell (VSMC) phenotype and vascular homeo…

New work from Daoud et al. shows that removal of YAP/TAZ from vascular smooth muscle cells triggers inflammation and immune activation- indicating these factors as essential in vascular health.#vascularbiology

sciencedirect.com/science/arti...

#CardioSky

Deletion of CHOP in beta cell protects mice from cardiovascular complications in type 2 diabetes: evidence from a pre-clinical mouse model Cardiovascular complications are the leading cause of morbidity and mortality in patients with type 2 diabetes (T2D), which is recognized as a major i…

We often treat #diabetes and #heart #disease separately — but they’re connected🫀.

A recent study from Srinivas, Alluri et al. shows that removing CHOP in β-cells protects against both metabolic dysfunction and cardiac fibrosis in T2D mice.

sciencedirect.com/science/arti...

#CardioSky #NewPaper

Age, sex, and vessel region affect the vasomotor function and gene expression signature of the aorta in mice Vascular aging is associated with endothelial dysfunction, changes in vascular elasticity or stiffness, and the prevalence of cardiovascular diseases.…

🫀 New in JMCC Plus!

Age, sex & vessel region shape vasomotor function in the descending thoracic #aorta — with #endothelial integrity & relaxation declining with age.

Want to know more- check out Saemann et al.:

sciencedirect.com/science/arti...

#CardioSky @jmccardiology.bsky.social

Quantification of morphological, functional, and biochemical features of H9c2 rat cardiomyoblast retinoic acid differentiation Cell culture models enable advancement in our understanding of heart development and heart disease. The H9c2 rat ventricular cardiomyoblast cell line …

New work from Nicole S. York and the group of Leigh Anne Swayne at the University of Victoria charts how #H9c2 heart cells change shape, signal, & express genes during differentiation—revealing both their promise & limits as #cardiomyocyte models.

#CardioSky

sciencedirect.com/science/arti...

Nanoscale architecture and dynamics of CaV1.3 channel clusters in cardiac myocytes revealed by single channel nanoscopy The clustering of L-type calcium channels for functional regulation of intracellular calcium signaling remains poorly understood. Here we applied supe…

Ever wondered how #Calcium channels cluster in #iPSC derived #Cardiomyocytes?

New work just published from Schwenzer et al. should put your mind at rest as they investigated just that!

Check out the latest paper for more information

www.sciencedirect.com/science/arti...

#CardioSky

Scientific Exchange Grants Your access to the latest cardiovascular news, science, tools and resources.

“Together, we innovate.” 🧬

@escardio.bsky.social is funding collaboration across borders

If you’re an #ECR in #cellular #cardiac #electrophysiology, this is your chance to build connections & push your science forward.

escardio.org/Research/Res...

Deadline- 8 Dec 2025

#CardioSky #BasicScience

Wnt/β-catenin signaling regulates cardiac Cx43 in a metabolic substrate-dependent manner Both Nav1.5 and Cx43 are critical for the fast electrical impulse conduction in the myocardium and their reductions create the arrhythmogenic substrat…

Looking for some weekend reading? 📜

New work from from the University of Ottawa Heart Institute, show how metabolic substrates regulate effects of Wnt/β-catenin signaling in #cardiomyocytes, specifically affecting regulation of #Connexin43

sciencedirect.com/science/arti...

Generation and evaluation of a novel PI3K-targeting gene therapy in the failing mouse heart and healthy sheep heart Heart failure (HF) remains a clinical challenge with cardiac dysfunction typically progressing even with treatment, and heart transplants only availab…

New paper out in our September issue from
Bass-Stringer and colleagues @bakerresearchau.bsky.social
looking at PI3K.

Exploring a new #genetherapy to improve heart function in mice and sheep.

sciencedirect.com/science/arti...

#CardioSky

Less than 24 hours to go before the #EWGCCE meeting kicks off @escardio.bsky.social #HeartHouse in the South of France! Looking forward to a great scientific programme and meeting up with colleagues and friends over the next days! Safe travels all!

#CardioSky

Really nice work just out in @jmccplus.bsky.social !
Congrats to the Authors

#CardioSky

49th EWGCCE Meeting 2025 on ESC 365 Seminar on Cellular Electrophysiology by the WG on Cardiac Cellular Electrophysiology to improve your practice and prepare for your exams.

Title deadline of 2nd June for @escardio.bsky.social
WG in #Cardiac Cellular #Electrophysiology meeting next month.

Want to hear about the latest work in cellular cardiac electrophysiology-, you know what you need to do!

#cardiosky

esc365.escardio.org/event/1815

Cross-Talk of Cells in the Heart 2025: Novel Mechanisms of Disease and Arrhythmias Cross-Talk of Cells in the Heart 2025, an exciting two-day meeting at University of Birmingham (UK) to discuss the latest breakthroughs in cardiac arrhythmia and disease research. Join us

Upcoming Abstract Deadline!

Interested in attending the Cardiac Cellular Cross Talk meeting in Birmingham in September?

Submit your abstract before the 2nd June! Its going to be a good one!

physoc.org/events/cross...

#CardioSky

RePOWER: Returning to Postgraduate Study in the Life and Environmental Sciences

Considering a return to study in the life/environmental sciences at Masters/PhD level after time away? Working and wondering if full/part-time study is the next step for your career? Our RePOWER workshop on 13th June in Oxford/online will provide advice and support. iles.web.ox.ac.uk/repower-retu...

49th EWGCCE Meeting 2025 on ESC 365 Seminar on Cellular Electrophysiology by the WG on Cardiac Cellular Electrophysiology to improve your practice and prepare for your exams.

Interested in presenting your latest #CardiacElectrophysiology data but didnt have chance to submit an abstract to this years #EWGCCE?

Still time to submit a title and register for this meeting happening in June/July
esc365.escardio.org/event/1815

Hopefully see you there!

#CardioSky

Some really nice work just out in @jmccplus.bsky.social
Congrats to the Authors!

#CardioSky

Really nice work just out... Interested in neuro-cardio interactions, have a read!

49th EWGCCE Meeting 2025 on ESC 365 Seminar on Cellular Electrophysiology by the WG on Cardiac Cellular Electrophysiology to improve your practice and prepare for your exams.

Deadline Extended until the 10th March for submission of abstracts for the WGCCE meeting this year happening in the south of France!

Submit your abstract today at
esc365.escardio.org/event/1815

This meeting is the perfect place to conduct some great conversations!!

#CardioSky

This should be a very interesting webinar! Looking forward to seeing you there!

#CardioSky

Fantastic news from @jmccplus.bsky.social 🥳🥳

Congrats to all involved..

Im currently hosting a #SpecialIssue on #Remodelling in #HFpEF! 🫀

Feel free to get in touch if you are interested in submitting!