Steroid hormone receptors through Cry2 are key
players in the circadian clock response to serum - in press at Nat Comms www.nature.com/articles/s41... Cry2 interacts with sex hormone receptors in the response to serum, independent from its effects on #circadian clock rhythm

Reduced Muscular Carnosine in Proximal Myotonic Myopathy—A Pilot 1H‐MRS Study Objective Myotonic dystrophy type 2 (proximal myotonic myopathy, PROMM) is a progressive multisystem disorder with muscular symptoms (proximal weakness, pain, myotonia) and systemic manifestations s...

Reduced Muscular Carnosine in Proximal Myotonic Myopathy—A Pilot 1H‐MRS Study - Gussew - Annals of Clinical and Translational Neurology - Wiley Online Library onlinelibrary.wiley.com/doi/pdf/10.1... @myoblue.bsky.social carnosine beyond sarcopenia: mechanistic biomarker of myopathy?

Circadian regulation of homologous recombination by cryptochrome1-mediated dampening of DNA end resection - Nature Communications The study shows that DNA double-strand break repair follows a circadian rhythm: homologous recombination peaks in the morning and declines by evening. CRY1 regulates CCAR2 to modulate this cycle, link...

Circadian regulation of homologous recombination by cryptochrome1-mediated dampening of DNA end resection | Nature Communications www.nature.com/articles/s41... role of #circadian clock components in DNA homeostasis is finally emerging

UC to lead study on inexpensive drug that could revolutionize ACL recovery time The drug is cheap and already used during surgery. The clinical study will look at whether taking it for seven days afterward could speed up recovery times in teenaged patients.

UC to lead study on drug that could revolutionize ACL recovery time | WVXU www.wvxu.org/health/2025-... pretty cool repurposing idea for tranexamic acid, also interesting is the putative indication for younger (~teenagers) patients

Myostatin Exhibits an Evolutionarily Conserved Circadian Pattern in Skeletal Muscles Introduction Myostatin (MSTN), a transforming growth factor-beta (TGF-β) superfamily member, is an evolutionarily conserved negative regulator of skeletal muscle mass. Loss of MSTN commonly promotes...

Myostatin Exhibits an Evolutionarily Conserved Circadian Pattern in Skeletal Muscles - Liu - 2025 - Journal of Cachexia, Sarcopenia and Muscle - Wiley Online Library onlinelibrary.wiley.com/doi/pdf/10.1... @myoblue.bsky.social #circadian

pretty cool concept

Deletion of fibro-adipogenic progenitors-specific follistatin impairs muscle function and accelerates skeletal muscle atrophy in obese mice - Molecular Medicine Background Follistatin is a potent regulator of various TGF-β superfamily members, including myostatin (MSTN) and activin A. Previous studies have shown that follistatin is crucial in enhancing myogen...

Deletion of fibro-adipogenic progenitors-specific follistatin impairs muscle function and accelerates skeletal muscle atrophy in obese mice | Molecular Medicine link.springer.com/article/10.1... @myoblue.bsky.social intriguing new role for FAPs: source of follistatin to control muscle mass

Cryo-electron microscopy reveals sequential binding and activation of Ryanodine Receptors by statin triplets | Nature Communications www.nature.com/articles/s41... @myoblue.bsky.social possible new mechanism for statin-driven myopathy

Cyberattacks' harm to universities is growing — and so are their effects on research Hackers are ramping up attacks on academic institutions to access valuable data and to demand ransoms.

“The number of cyberattacks is not relenting”

Hackers are ramping up attacks on academic institutions to access valuable data and to demand ransoms

go.nature.com/49tiOCc

Exclusive: CDC to end all monkey research Studies related to HIV and other infectious diseases will be phased out, sources say; fate of the agency's animals remains unclear

Exclusive: Scientists at the U.S. Centers for Disease Control and Prevention have been told to phase out all of their monkey research, Science has learned. https://scim.ag/48foQEk

DST does not save energy. “Arizona would consume more energy if it implemented Daylight Saving Time.” #DitchDST!

Mifepristone alone and in combination with scAAV9-SMN1 gene therapy improves disease phenotypes in Smn2B/- spinal muscular atrophy mice Scientific Reports - Mifepristone alone and in combination with scAAV9-SMN1 gene therapy improves disease phenotypes in Smn2B/- spinal muscular atrophy mice

Excited to share Emma Sutton's recently published Ph.D. research! By using cells, worms and mice, we report that mifepristone, a glucocorticoid receptor anatagonist, alone and in combination with an approved SMN-dependent therapy, has the potential to improve SMA disease pathology.
rdcu.be/eQpXG

Intrinsic dysfunction in muscle stem cells lacking dystrophin begins during secondary myogenesis - Nature Communications In mdx mouse fetuses, the lack of dystrophin markedly impairs secondary myogenesis due to reduced muscle stem cell polarity. AAK1 deletion restores polarity and rescues secondary myogenesis, revealing...

Intrinsic dysfunction in muscle stem cells lacking dystrophin begins during secondary myogenesis | Nature Communications www.nature.com/articles/s41... @myoblue.bsky.social

Gene therapy CM-YAPon protects the mouse heart from myocardial infarction - Nature Cardiovascular Research Meng et al. develop the adeno-associated virus 9-based therapy CM-YAPon to transiently and inducibly express YAP in the heart. In mice, CM-YAPon promoted cardiomyocyte cell cycle reentry and reprogram...

www.nature.com/articles/s44...

Impaired cAMP–PKA–CREB1 signalling drives mitochondrial dysfunction in skeletal muscle during cancer cachexia - Nature Metabolism Tumour-induced dysregulation of cAMP–PKA–CREB1 signalling in skeletal muscle is shown to be a driver of mitochondrial dysfunction, contributing to cancer cachexia in mice.

www.nature.com/articles/s42... cancer promotes cachexia by disrupting cAMP signaling in muscle @myoblue.bsky.social

IN MEMORIAM: A totipotent embryologist: John B. Gurdon
(1933–2025)
By Thoru Pederson
➡️ https://tinyurl.com/gd353471OA

*Photo courtesy of the Cold Spring Harbor Laboratory Archives.

Lactylation of mTOR enhances autophagy in skeletal muscle during exercise Based on an acute exercise model, Yan et al. identify lactate as a positive regulator of autophagy in skeletal muscle. Lactate triggers muscle autophagy via K921 lactylation-dependent inactivation of ...

Lactylation of mTOR enhances autophagy in skeletal muscle during exercise
www.cell.com/cell-chemica...

Dystrophinopathy in ACTION: The first 500 males enrolled in the Advanced Cardiac Therapies Improving Outcomes Network prospective dystrophinopathy registry The Advanced Cardiac Therapies Improving Outcomes Network formed a dystrophinopathy registry to define cardiac diagnostics, management, and advanced t…

Dystrophinopathy in ACTION: The first 500 males enrolled in the Advanced Cardiac Therapies Improving Outcomes Network prospective dystrophinopathy registry - ScienceDirect www.sciencedirect.com/science/arti... @myoblue.bsky.social @cardiosky11.bsky.social

Viral Infections and Risk of Cardiovascular Disease: Systematic Review and Meta‐Analysis | Journal of the American Heart Association

Vaccines save lives in more ways than one.

Flu, COVID, HIV, HCV, and HZV were associated with an increased risk of major cardiovascular events. Vaccines may have important role in reducing the risk of cardiovascular disease… #IDSky #vaccine #COVID

www.ahajournals.org/doi/10.1161/...

Ohio house committee held a third hearing on permanent Daylight Saving Time. All written testimony opposed (thank you!). No oral testimony occurred (we spoke at the second hearing in May). No discussion or vote occurred. Tell your OH state reps NO on HCR 10!

7 basic science discoveries that changed the world Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government.

Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government

www.nature.com/articles/d41...

Munc13-1 restoration mitigates presynaptic pathology in spinal muscular atrophy - Nature Communications Defective neurotransmission is a hallmark of spinal muscular atrophy (SMA). Here, the authors show that local presynaptic Munc13-1synthesis is defective in SMA and that modification of the Munc13-1 mR...

Munc13-1 restoration mitigates presynaptic pathology in spinal muscular atrophy | Nature Communications www.nature.com/articles/s41... #myoblue @myoblue.bsky.social

Maps and photos of winter sunrise times in Pennsylvania. Permanent Standard Time keeps sunrise before 8am. Permanent DST keeps it dark long past 8am.

PENNSYLVANIA State Rep Joe McAndrew files HR 349 for permanent Daylight Saving Time. Would put sunrise past 8am for 3 months, to nearly 9am. Tell your PA state reps NO on HR 349—and yes instead on HB 119 for permanent Standard Time! 🔗👇

“Be Honest, Thank You” meme: • Woman: “Daylight Saving Time helps farmers, children, workers…” • Man: “Be honest.” • Woman: “I am being honest!” • Man: “Be honest! Why do we really have DST?” • Woman: “DST profits shopping malls, golf associations, and candy merchants.” • Man: “Thank you.”

Honestly, why do we even have Daylight Saving Time?

www.researchsquare.com/article/rs-7... intriguing preprint on myonuclei motility in muscular dystrophy, particularly in light of centronucleation and regeneration #myoblue

Scientist on front lines of overdose crisis receives MacArthur 'genius' award Nabarun Dasgupta was recognized with a MacArthur "genius" award for work studying the deadly overdose crisis. He's also a front-line organizer, helping people survive.

Scientist on front lines of overdose crisis receives MacArthur 'genius' award : NPR www.npr.org/2025/10/08/n...

This 4-year-old's heart is failing. A federal grant that might help him was canceled A Cornell University researcher has been developing an artificial heart for children for more than 20 years. Now, his research is on hold and his lab is shut down.

How Trump's research cuts affect a 4-year-old in heart failure : NPR www.npr.org/2025/10/09/n... this is tragic

Screenshot of article linked below.

Canadians, tell your MPs and MLAs/MPPs/MNAs/MHAs to listen to sleep doctors, support permanent Standard Time and not permanent Daylight Saving Time!

Nobel Laureate Professor Sir John Gurdon dies aged 92 It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.

So sad to hear the news - John truly was an inspiration to so many, and one of a kind.

www.cam.ac.uk/research/new...

Weaponizing uncertainty in science and in public health puts people in harm’s way Those who cite scientific studies to support policies should take care to tell the whole story, especially when it’s complex.

Public health decisions must be made in line with the consensus of experts

go.nature.com/46Oxl8p