www.researchsquare.com/article/rs-7... intriguing preprint on myonuclei motility in muscular dystrophy, particularly in light of centronucleation and regeneration #myoblue

Scientist on front lines of overdose crisis receives MacArthur 'genius' award Nabarun Dasgupta was recognized with a MacArthur "genius" award for work studying the deadly overdose crisis. He's also a front-line organizer, helping people survive.

Scientist on front lines of overdose crisis receives MacArthur 'genius' award : NPR www.npr.org/2025/10/08/n...

This 4-year-old's heart is failing. A federal grant that might help him was canceled A Cornell University researcher has been developing an artificial heart for children for more than 20 years. Now, his research is on hold and his lab is shut down.

How Trump's research cuts affect a 4-year-old in heart failure : NPR www.npr.org/2025/10/09/n... this is tragic

Screenshot of article linked below.

Canadians, tell your MPs and MLAs/MPPs/MNAs/MHAs to listen to sleep doctors, support permanent Standard Time and not permanent Daylight Saving Time!

Nobel Laureate Professor Sir John Gurdon dies aged 92 It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.

So sad to hear the news - John truly was an inspiration to so many, and one of a kind.

www.cam.ac.uk/research/new...

Weaponizing uncertainty in science and in public health puts people in harm’s way Those who cite scientific studies to support policies should take care to tell the whole story, especially when it’s complex.

Public health decisions must be made in line with the consensus of experts

go.nature.com/46Oxl8p

YouTube video by National Geographic Official Film Trailer: JANE | National Geographic

"Jane" (2017), directed by Brett Morgen, with music by Philip Glass, and based on unseen footage discovered shortly before, is one of the most enchanting films I've ever seen. Goodbye Jane Goodall, and thank you.

www.youtube.com/watch?v=FRlU...

This piece by @olivia.science et al is a fantastic read for anyone navigating AI in academia — I’ve included it in the reading for the lecture I’m giving to MSc students later this week

Screenshot of headline from Astronomy magazine. Article is linked below.

“Most people would experience the least circadian burden under permanent Standard Time, which prioritizes morning light.” #DitchDST #SaveStandardTime

www.nature.com/articles/s44...

Many of us have been saying this for a long time. The only question is whether LLM’s are now “too big to fail” given the massive investments currently at risk.

The future of gene therapy: Safer vectors, sharper focus While low-dose adeno-associated virus (AAV) gene therapy has been generally well tolerated, multiple recent reports have documented fatalities associated with high-dose AAV vectors. These events have ...

The future of gene therapy: Safer vectors, sharper focus: Molecular Therapy www.cell.com/molecular-th... sobering commentary on the present challenges in AAV-based gene therapy @myoblue.bsky.social

oh boy, that's gonna make for a thorny discussion

oh boy, I didn't know that!

Elegant functional genomics that helps explain increases in cholesterol & atherosclerosis after menopause.

@mattiaquattro.bsky.social & team discover a nonrare variant encoding the human glucocorticoid receptor that increases cholesterol & promotes atherosclerosis

buff.ly/rQEt53L

Time-restricted feeding mediated synchronization of circadian rhythms to sustain cardiovascular health Circadian rhythm is critical in maintaining metabolic homeostasis, including cardiac health, with disruptions often leading to adverse cardiac outcomes. Time-restricted feeding/eating (TRF/TRE) is a d...

Time-restricted feeding mediated synchronization of circadian rhythms to sustain cardiovascular health - @jmccardiology.bsky.social www.jmcc-online.com/article/S002... excited to share this review on time-restricted feeding in our JMCC special issue on #circadian biology #cardiosky

A brief history of circadian time in the heart This review tracks the discovery of circadian biology in cardiovascular science, starting with early clinical observations of daily changes in heart rate, blood pressure, and cardiovascular events. Th...

A brief history of circadian time in the heart - @jmccardiology.bsky.social www.jmcc-online.com/article/S002... excited to share this excellent historical perspective on our JMCC special issue on #circadian biology #cardiosky

Circadian transcriptional repressors REV-ERBα/β and E4BP4 regulate cardiac function Circadian rhythms are an endogenous timekeeping system with a period of approximately 24 h that regulate many aspects of body physiology to maintain organismal health. Dysregulation of circadian rhyth...

Circadian transcriptional repressors REV-ERBα/β and E4BP4 regulate cardiac function - @jmccardiology.bsky.social www.jmcc-online.com/article/S002... excited to share this new contribution to our JMCC special issue on #circadian biology #cardiosky

In 1900, 31% of all deaths were children under the age of 5. Today it’s 0.7%. Vaccines, medications, and modern science are the reason why. Trust the science, it’s been proven to work safely and efficiently time and time again.

Opinion | Robert F. Kennedy Jr., the CDC and Me I was fired after 29 days because I held the line and insisted on rigorous scientific review.

What Dr. Monarez, the CDC Director for 1 month, has to say about why she was fired
www.wsj.com/opinion/robe...

C3 Visit the post for more.

excited about our upcoming #Cincinnati #Circadian #Conference on Sept 19th ! We will have keynote lectures from Dr. Michael Rosbash (2017 Nobel Prize) and Dr. Selma Masri (2022 SRBR Award), plus 4 selected talks, plus 20+ posters! Register here, spots are limited: scienceoflightcenter.org/c3/

Proximity-specific ribosome profiling reveals the logic of localized mitochondrial translation Development of LOV-domain-controlled ligase for translation localization (LOCL-TL), an optogenetic approach for monitoring translation with codon resolution at any defined subcellular location under p...

Proximity-specific ribosome profiling reveals the logic of localized mitochondrial translation: Cell www.cell.com/cell/fulltex...

The #C3 #Cincinnati #Circadian #Conference will return in a new format and setting this September 19th with a keynote from Selma Masri (UC Irvine). Checkout the updated program here scienceoflightcenter.org/c3/, there's still time to register for free to participate in person!

Integrated Systems Biology Identifies Disruptions in Mitochondrial Function and Metabolism as Key Contributors to HFpEF Heart failure with preserved ejection fraction (HFpEF) accounts for ∼50% of HF cases. The ZSF1-obese rat model recapitulates clinical features of HFpE…

Integrated Systems Biology Identifies Disruptions in Mitochondrial Function and Metabolism as Key Contributors to HFpEF - ScienceDirect www.sciencedirect.com/science/arti... happy to finally see this out, congrats Andrew @cardiometabosci.bsky.social

Risdiplam in Presymptomatic Spinal Muscular Atrophy | NEJM Risdiplam, an oral pre–messenger RNA splicing modifier, is an efficacious treatment for persons with symptomatic spinal muscular atrophy (SMA). The safety and efficacy of risdiplam in presymptomati...

Risdiplam in Presymptomatic Spinal Muscular Atrophy | New England Journal of Medicine www.nejm.org/doi/abs/10.1... encouraging results with early postnatal intervention with a small oral pre–messenger RNA splicing modifier #myoblue

Risdiplam in Presymptomatic Spinal Muscular Atrophy | NEJM Risdiplam, an oral pre–messenger RNA splicing modifier, is an efficacious treatment for persons with symptomatic spinal muscular atrophy (SMA). The safety and efficacy of risdiplam in presymptomati...

Risdiplam in Presymptomatic Spinal Muscular Atrophy | New England Journal of Medicine www.nejm.org/doi/abs/10.1... encouraging results with early postnatal intervention with a small oral pre–messenger RNA splicing modifier #myotwitter

The CCL2-CCR2 axis drives neuromuscular denervation in amyotrophic lateral sclerosis - Nature Communications Neuromuscular junctions (NMJs) are denervated in amyotrophic lateral sclerosis (ALS) through unknown mechanisms. Here, the authors show immune cells infiltrating muscle of ALS patients and mouse model...

The CCL2-CCR2 axis drives neuromuscular denervation in amyotrophic lateral sclerosis | Nature Communications www.nature.com/articles/s41... important and consequential work, finally provides a solid mechanistic rationale for immunological interventions in ALS

Sympathetic innervation maintains the murine quiescent skeletal muscle stem cell pool via perivascular-derived Angpt1 Muscle stem cells rely on their niche for maintenance, yet how β-adrenergic innervation regulates these cells remains elusive. Here, we show that symp…

Sympathetic innervation maintains the murine quiescent skeletal muscle stem cell pool via perivascular-derived Angpt1 - ScienceDirect www.sciencedirect.com/science/arti... @myoblue.bsky.social

Removal of promoter CpG methylation by epigenome editing reverses HBG silencing - Nature Communications DNA methylation is a critical component for repression of fetal haemoglobin in adult blood cells. Removing DNA methylation from the fetal haemoglobin promoter effectively upregulates the gene, opening...

Removal of promoter CpG methylation by epigenome editing reverses HBG silencing | Nature Communications www.nature.com/articles/s41... elegant and effective esample of epigenetic therapy at its best!

few outcomes, except for 99% of FDA-approved drugs, 174 recipients of 104 Nobel Prizes, training ~30K MDs and ~10K PhDs per year to enter the workforce, and a 34% reduction in age-adjusted cancer deaths since 1990 -- the largest decrease in history