Great to be involved in this research on the Ghrelin receptor, out now in Molecular Cell - with potential for translation to improve quality of life for Parkinson's disease patients!
Download now for free via this link:

authors.elsevier.com/c/1lARg3vVUP...

www.uq.edu.au/news/article...

dFLASH; dual FLuorescent transcription factor activity sensor for histone integrated live-cell reporting and high-content screening - Nature Communications Arrayed and pooled high-throughput screening is crucial for drug discovery and CRISPR functional genomics. Here, the authors present dFLASH; a dual FLuorescent transcription factor Activity Sensor for...

Interested in drug or genetic screens? Have a look at our ‘new’ paper in @naturecomms.bsky.social special thanks to Tim and Ali and the labs groups that have supported me and this work. www.nature.com/articles/s41...

When you don't have new results to show in your lab meeting

Or fringe diseases that suddenly become….. pandemics. Or perhaps unexplained cow sickness that becomes mainstream….

What it feels like revising a paper

This is pretty cool approach!

Engineering synthetic phosphorylation signaling networks in human cells Protein phosphorylation signaling networks have a central role in how cells sense and respond to their environment. We engineered artificial phosphorylation networks in which reversible enzymatic phos...

Engineering synthetic phosphorylation signaling networks in human cells

“in human T cells, such a circuit could sense tumor necrosis factor–α and maintain controlled cytokine secretion”

www.science.org/doi/10.1126/...

Progress on the quest for a red mStayGold!
Just out: mScarlet3-S2, a new photostable red FP derived from mScarlet3: www.researchsquare.com/article/rs-5...

Development of compact transcriptional effectors using high-throughput measurements in diverse contexts - Nature Biotechnology Improved effectors for CRISPRi/CRISPRa are developed following high-throughput screening of transcriptional domains.

New here and excited to share our new paper on transcriptional effectors! Interested to discuss context-specificity of gene regulation? Or how to get CRISPRi/a working in new contexts? 👋
www.nature.com/articles/s41...

I scroll down and all I see is science and enthusiasm…. It’s great!!!

Meet Evo, the DNA-trained AI that creates genomes from scratch ChatGPT-like model learns on its own to devise new proteins and genetic sequences

"malicious users could exploit a model like Evo to design a biological weapon, so the researchers banished from the training set any viruses that attack eukaryotes" 👀 www.science.org/content/arti...

Insect factory making plenty of mCherry!

Multiplexed perturbation of yew reveals cryptic proteins that enable a total biosynthesis of baccatin III and Taxol precursors Plants make complex and potent therapeutic molecules, but difficulties in sourcing from natural producers or chemical synthesis can challenge their use in the clinic. A prominent example is the anti-c...

Check out lab member Conor McClune's new preprint! He and Jack Liu in the Sattely lab at Stanford used single-cell transcriptomics from multiple plant tissues in the presence of perturbations to discover *8* new genes in the Taxol biosynthesis pathway!
biorxiv.org/content/10.1... (1/n)