Maxim Greenberg

My read of the article was quite different. The AI researchers are like a bunch of bemused Dr Frankensteins. Something so powerful has been created, and we don't know exactly how it works (the wright brothers/747 analogy). It's all so fascinating.

Events for February 2026 06-07 July 2026 | Munich, GermanyDNA Replication and Its Impact on Genome and Chromatin MaintenanceWe are RepliFate, a European Training Doctoral Network dedicated to understanding how DNA replication...

We go live!!!

Join us Munich July5-7th to hear exciting research on #Replication by leaders in the field

AND !! registration is FREE 🥳 (but mandatory) - we hope to see many in Munich 🍺 @helmholtzmunich.bsky.social

@replifate.bsky.social @epicrossborders.bsky.social

replifate.eu/event/meetin...

Love this!

🎉 After a very long one (appropriately…), I’m excited to share work revealing an unexpected role for the epigenetic regulator ZFP57 - linking development, lactation, milk composition and lifelong health.

Check it out: www.nature.com/articles/s41...
#MammaryGlandBiology #DOHaD

For once an article about the "how to get to Rome" and not "Rome" itself. Collaboration with my "partner-in-crime" @felibas.bsky.social has been a key ingredient of my research over the years. Sara Miller at Molecular Cell spoke with us of how we got there and what we think about collaborations.

Postdoc job alert at Institut Jacques Monod in Paris! Interested in fundamental membrane trafficking? We seek a postdoc to study collagen secretion as a model for core principles of how cells and their environment build each other. emploi.cnrs.fr/Offres/CDD/U...

Our new preprint on SMCHD1! We’ve shown SMCHD1’s ATPase activity is critical for function in vivo, and excitingly a new DNA binding domain neighbouring the ATPase domain activates the enzymatic function, which is important for normal chromatin binding.
urldefense.com/v3/__https:/...

‘All It Is Is Pain’: The Olympian Testing the Limits of Endurance

I am in awe of elite endurance athletes www.nytimes.com/2026/02/05/m...

Please share: we're hiring a new tenure-track faculty member to our Department of Genetics at Albert Einstein College of Medicine.

faculty-einstein.icims.com/jobs/17847/a...

Michal Gdula group leader at @uam-ibmib.bsky.social is saerching for a postdoc to work on the epigenetics of pancreatic cancer within colaborative OPUS-LAP funded by @ncn.gov.pl and @dfg.de - reach out! #3Dgenome #cancer #pancreas

Chapelle!!! That was the BIGGEST comedy show of the early 2000s and still is referenced all the time.

Unique territorial and compartmental organization of chromosomes in the holocentric silkworm - The EMBO Journal Hallmarks of multicellular eukaryotic genome organization are chromosome territories, compartments, and loop-extrusion-mediated structures, including TADs. However, these have mainly been observed in ...

How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms?
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment
link.springer.com/article/10.1...

Between the Kennedy Center news and this, it's been a bad week for Washington... 😥

DOT1L provides transcriptional memory through PRC1.1 antagonism - Nature Cell Biology Neville, Ferguson et al. show that non-canonical Polycomb repressive complex 1.1-mediated gene silencing is antagonized by DOT1L and is required for the therapeutic efficacy of Menin and DOT1L inhibit...

H3K79me2/3 is sufficient to antagonise PRC1 www.nature.com/articles/s41...

Top: FK506-resistant strains isolated from the Mucor circinelloides complex. Phenotypic analysis of FK506-resistant isolates in Mucor janssenii CBS185.68 (PS1), Mucor bainieri CBS293.63 (PS3), and Mucor atramentarius CBS202.28 (PS6). WT, wild-type; M, mendelian mutant; E, epimutant. Bottom: Schematic overview of epigenetic silencing contributing to antifungal resistance in Mucor species. fkbA expression enables FKBP12 production and FK506 sensitivity (yeast-like morphology). Epigenetic silencing of fkbA via RNAi and/or heterochromatin leads to FK506 resistance and hyphal growth. Generated with BioRender.com.

#Antifungal resistance is a global threat, but epigenetic mechanisms drive rapid, reversible adaptation in fungi. This study shows that #RNAi or #heterochromatin driven #epimutations transiently silence the gene fkbA to confer FK506 #tacrolimus resistance in #Mucor @plosbiology.org 🧪 plos.io/4qdttWc

I started offering career advice to two junior colleagues today in separate meetings, and both times I caught myself thinking that, if I'm honest, I don't have very good advice on navigating the current funding and job climate. I think it's important to say that no one does.

🚨 1/ Preprint Alert!

Sex determination outcome is conserved across vertebrates (i.e. generating 2 compatible sexes) ♀️♂️

But are the cell types and gene programs behind them conserved too? 🧬

Spoiler: not really 👀

Find out in our new preprint ⬇️

www.biorxiv.org/content/10.6...

Finally, for the aficionados, here's a fun paper on the evolutionary origins of Ezhip—a mammal-specific innovation—from @pravrutharaman.bsky.social and @harmitmalik.bsky.social www.biorxiv.org/content/10.6...

From Raphael Margueron's lab @institutcurie.bsky.social 3/4 www.nature.com/articles/s41...

EZHIP restricts noncanonical PRC2 binding and regulates H3K27me3 intergenerational inheritance and reprogramming Zeng et al. identify EZHIP as a critical epigenetic reprogramming factor in mouse early embryos, which promotes global erasure, intergenerational inheritance, and re-establishment of H3K27me3. They de...

From Wei Xie's lab www.cell.com/cell-stem-ce... 2/4

During germline epigenetic reprogramming, Polycomb must be restricted in the gametes to ensure proper genome regulation in the fertilized embryo. 2 must-read papers assess what happens when Ezhip (Polycomb antagonist) is lost. They come to highly similar conclusions and should be read in tandem 1/4

Finally, for the aficionados, here's a fun paper from @pravrutharaman.bsky.social and @harmitmalik.bsky.social on this mammal-specific innovation. www.biorxiv.org/content/10.6...

EZHIP restricts noncanonical PRC2 binding and regulates H3K27me3 intergenerational inheritance and reprogramming Zeng et al. identify EZHIP as a critical epigenetic reprogramming factor in mouse early embryos, which promotes global erasure, intergenerational inheritance, and re-establishment of H3K27me3. They de...

From Raphael Margueron's lab @institutcurie.bsky.social 3/4 www.cell.com/cell-stem-ce...

EZHIP restricts noncanonical PRC2 binding and regulates H3K27me3 intergenerational inheritance and reprogramming Zeng et al. identify EZHIP as a critical epigenetic reprogramming factor in mouse early embryos, which promotes global erasure, intergenerational inheritance, and re-establishment of H3K27me3. They de...

From Wei Xie's lab 2/4 www.cell.com/cell-stem-ce...

‘Crisis’: The fallout from Trump’s surprise plan to close Kennedy Center The president’s announcement shocked artists and staff. A letter obtained by The Washington Post brought the National Symphony Orchestra’s future into focus.

Trump is butthurt that no one wants to play at the Kennedy Center, so he is closing it for 2 years. I know this seems like small potatoes compared to everything else, but as a native Washingtonian (and whose parents are season ticket holders), this absolutely enraged me today.... wapo.st/4qhUb0b

Somehow this escaped my attention! Congrats to Benoit, Francois and the rest for this great story!!

🔔 New paper alert 🔔 www.nature.com/articles/s41...
Some regions in the genome replicate early and some late, but the why and how remain poorly understood. DNA replication and 3D genome organization appear linked, raising the question if one may regulate the other? (1/n)

Remember when Matt Walsh argued that the Little Mermaid can't be black because sea creatures are pale 😂

Dont miss out on it ! Hands on Summer School.
Cut&Run, Cut@Tag, ChIP, ATACseq and analyse your own data ! ➡️Unique opportunity ! 14 exiting days ➕ Daily high profile lectures.
👉 Applications & info: bit.ly/4oGDR8f

From Sunday Long Read Newsletter: The “Melania” reviews piled up like a multi-vehicle crash on Friday and the digital rubbernecking, while a horrifying new batch of 3 million Epstein files documents dropped to, uh, digest, made for a macabre delight. Why did Jeffrey Bezos pay $40 million for this bizarrely bad, bland infomercial (and another $35 million to promote it)? And it was impossible to ignore the fact that this zero-stars bomb debuted the same week of reports that Bezos’ Washington Post is kneecapping the paper’s beloved and legendary sports desk and gutting its vaunted foreign staff. How many Post journalists’ (relatively meager) salaries could be paid for a fraction of the cost of a “horrific” film that Xan Brooks calls “an elaborate piece of designer taxidermy, horribly overpriced and ice-cold to the touch and proffered like a medieval tribute to placate the greedy king on his throne?” The answer is obvious, of course. Too often these days, billionaires choose to pay to placate power rather than pay people to speak truth to it.

Man @dvnjr.bsky.social is not holding back!