Maxim Greenberg

Scientific journals: we don’t want you using generative AI because it makes shit up.

Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote

Same journal: AI cover art which makes no sense? Oooh!

I asked AI if there’s a German word for being in awe of something that will destroy us

Intracellular competition shapes plasmid population dynamics From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...

Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...

Far right to the rescue on Europe’s gene-editing revolution Previously ignored, two far-right lawmakers could end an impasse on gene-edited plants.

« Far right to the rescue on Europe’s gene-editing revolution »
😳 whaaa???
Why can’t European socialist parties be more supportive of science?

www.politico.eu/article/far-...

The CDC has been taken over by the people who didn’t trust the CDC. We live in the upside down

It’s hard to correctly estimate the level of fumigation that will be required to restore public trust and proper function in the CDC (and several other executive branches) after what has occurred over the past ten months (has it really only been ten months?!)

Polycomb Repressive Complexes 1 and 2 are recruited independently to pericentromeric heterochromatin in response to hypomethylation in mouse embryonic stem cells Pericentromeric heterochromatin (PCH) is delineated by the enrichment of repressive epigenetic modifications, specifically trimethylated histone H3 at lysine 9 (H3K9me3) and DNA methylation (5-methylc...

www.biorxiv.org/content/10.1...

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Fun week for DNA methylation research! Here is a thread of three cool papers that came out, all with an evolution angle. And a bonus 4th that examines DNAme/PcG interplay (certainly an interest for our lab!) #Epigenetics

"When I say epigenetics what I really mean is DNA methylation in multicellular eukaryotes," just doesnt have the same ring to it. I'll consider your advice 😅.

Nice Alex!! Congrats!!

Adenine DNA methylation associated with transcriptionally permissive chromatin is widespread across eukaryotes - Nature Genetics Long-read sequencing in 18 unicellular eukaryotes reveals that 6mA is widespread across eukaryotes and is enriched at transcriptionally permissive regions, which are also marked by H3K4me3.

Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9

Et tu, @plosbiology.org ?

Cadherins modulate the self-organizing potential of pseudo-embryos Gastruloids derived from ES cells mimic embryonic patterning through robust self-organization. Mayran et al. uncover that this competence depends on a cadherin switch regulated by Snai1-driven E-cadhe...

Happy to present the final version of our Cadherin and gastruloid manuscript, online at @cp-cellreports.bsky.social.
www.cell.com/cell-reports...
Initially in BiorXiv (www.biorxiv.org/content/10.1...) 1/12

Congrats Zayna 👏!

It’s been an immense pleasure to present and discuss our work on genome organization and genomic imprinting with the Canadian community at the CEEHRC Epigenetics meeting #CanEpi25 in beautiful Banff. Immensely grateful to the trainee committee for their kind invitation

My lab is recruiting a post-doc ! please share ! emploi.cnrs.fr/Offres/CDD/U...

Opinion | Shocked by Trump’s profiteering? Here’s some perspective. There are periods in American history when graft was the rule, not the exception.

It is shocking how bad the @washingtonpost.com editorial page has become in the last year. The thrust of this article (so you don't have to read it) is "yeah, Trump is corrupt, but so were presidents in the 1880s" and I quote "In short, we need to get a grip." www.washingtonpost.com/opinions/202...

Vertebrate rna directed dna methylation!

That’s why you have use “enthusiastic” instead of “ambitious”. You angle for someone who *wants* to be in the lab at 9AM on Saturday 😂

Fantastic Allegra! Great to see this out, can't wait to read!! Congrats to all the authors!

1/ I’m very excited to share my postdoc work with @kseskv.bsky.social, in collaboration with @oligriffith.bsky.social. We explore embryonic DNA methylation reprogramming in the fat-tailed dunnart, an Australian marsupial 🦘🌏 www.biorxiv.org/content/10.1...

A preprint‼️that's bound to ruffle some 🪶 "Widespread DNA off-targeting confounds studies of RNA chromatin occupancy" led by our Micah Goldrich and Louis Delhaye from
Pieter Mestdagh in Ghent. TL;DR we show that many of lncRNA chromatin occupancy obtained are flawed www.biorxiv.org/content/10.1...

New paper from the lab: we’re using long-read sequencing to disentangle isoform complexity at allele-specific loci 🧬💡
Here, we combine the PacBio Iso-Seq workflow with the established WhatsHap phasing approach to assign long reads to the correct allele in polymorphic F1 mouse hybrids.

Are you an early-stage graduate student (2nd or 3rd year) or early-stage postdoc based in the US or Canada, working primarily in Drosophila? Would you like to help improve the experience of all trainees working in Drosophila research? If so, read on.

(Please repost to reach a broad audience.)

Just out! Our work on active transport in epithelial tissues. Congrats to Huiqiong Wu, Greg Arkowitz and Ranjith Chilupuri in collaboration with C. Duclut and J. Prost!
PNAS www.pnas.org/doi/10.1073/...

I am thinking of not replacing but assisting human review. Say, a human reviewer is assigned 10 preprints to screen. 9 of them are greenlighted by AI, so the human will only briefly glance at them. Only one preprint is flagged by AI, so the human will spend more time on this one preprint. Saves time

I feel like I'm going crazy. Is reviewing grants and papers time-consuming and painful, but a vitally important part of our job and the scientific enterprise? Or is it drudge work we're supposed to outsource to AI?