Anand Patel

Back on the inpatient leukemia service for a 2-week stretch! I will be posting daily articles as usual!

Day 1 - time to treatment with HMA + VEN in newly dx AML

pubmed.ncbi.nlm.nih.gov/40702896/

Feeling inspired after the @ash.hematology.org Committee on Educational Affairs meeting!

1/ This is a long 🧵, so buckle up & I hope you read till the end.
The HHS Secretary, is planning to remove all 16 members of the USPSTF the expert panel that decides which preventive services (cancer screenings, HIV prevention meds) must be covered by insurers under the Affordable Care Act.

Happy to share new work led by senior fellow Dr. Sam Yates! We found that time from diagnosis to treatment does not impact overall survival in pts w/ newly diagnosed AML treated with HMA + VEN!

haematologica.org/article/view...

More than 100 humanitarian groups warn of mass starvation in Gaza A joint statement says the Israeli government's "siege" has left aid supplies "totally depleted".

This is deeply shameful. Over 1,000 Palestinians have been killed while trying to get aid in the past 8 weeks. Israel must immediately cease these shootings & lift the blockade. Congress must pass the UNRWA Funding Emergency Restoration Act to help distribute aid in Gaza

www.bbc.com/news/article...

thanks to @oncbrothers.bsky.social for having me on to discuss AML!

oncbrothers.com/algo-aml-2025

helpful @bloodjournals.hematology.org study focusing on IDH1 and IDH2 as markers of MRD in AML!

ashpublications.org/bloodadvance...

New paper in @bloodjournals.hematology.org focused on olutasidenib +/- azacitidine in IDH1m MDS

ashpublications.org/bloodadvance...

An interesting article in Haematologica analyzing the characteristics of patients with AML who don't receive treatment
-9% of pts with AML did not receive treatment (40/429)
-most common reasons were pt pref (73%), med
reasons/doc rec (25%)

haematologica.org/article/view...

Stand up with ASH and #Fight4Hematology! 🩸💪

As executive orders threaten hematologic research and care of patients, ASH has created a new #Fight4Hematology Action Hub to keep you informed and involved.

Learn how to protect #hematology: www.hematology.org/a...

#HemeSky #MedSky

Very excited to share that I was selected for a 2025 National Cancer Institute Early Career Investigator Award!

@uchicagocancer.bsky.social @uchicagomedicine.bsky.social

reporter.nih.gov/search/OYXYV...

grateful to be a part of this comprehensive review led by @leivaorly.bsky.social focused on pulm HTN and HF in patients with MPNs!

www.jacc.org/doi/10.1016/...

very interesting study on how JAK2 inhibition may select for RAS pathway mutations in MPNs!

www.nature.com/articles/s41...

the 2025 ELN guidelines for CML are out!

www.nature.com/articles/s41...

Got to see the incredible Ramy Youssef perform tonight!

A very practical retrospective report demonstrating limited benefit of phlebotomy in patients with secondary/idiopathic polycythemia!

onlinelibrary.wiley.com/doi/10.1111/...

an excellent article looking at various subtypes of myeloid malignancies!

-SF3B1 VAF matters for MDS subtypes
-blast % doesn't matter for NPM1m; HR mutations impact outcome in NPM1m AML
-molecular data helps to separate oligomonocytic CMML from MDS

aacrjournals.org/bloodcancerd...

helpful report of asciminib in R/R Ph+ ALL! High rates of remission but limited overall survival

pubmed.ncbi.nlm.nih.gov/40601900/

America is beautiful, contradictory, unfinished. I am proud of our country even as we constantly strive to make it better, to protect and deepen our democracy, to fulfill its promise for each and every person who calls it home.

Happy Independence Day. No Kings in America.

So excited to share that @ash.hematology.org Self Assessment Program (SAP) 9th edition is out! I had the honor of serving as part of an incredible editorial team and co-author the MPN chapters

ashpublications.org/books/book/1...

New paper in @bloodjournal.bsky.social reporting a score incorporating IPSS-M, EPO level, transfusion dependence to predict ESA response in LR-MDS

ashpublications.org/blood/articl...

Really impossible to overstate how completely this guy has failed at every aspect of being an opposition leader over the past six months. Jeffries is a truly inspiring example for every soulless careerist who would rather be king of nothing than stand for anything decent in the world.

Moving Beyond The Eyeball Test for Fitness Assessment in AML Samuel J. Yates, Heidi D. Klepin; Moving Beyond The Eyeball Test for Fitness Assessment in AML, Blood Advances, , bloodadvances.2025016235, https://doi.org

a very nice commentary in @bloodjournals.hematology.org on incorporation of fitness assessment into AML workup written by @uchicagocancer.bsky.social hem/onc fellow Sam Yates et al!

ashpublications.org/bloodadvance...

Elderly and disabled people told Congress that cutting Medicaid could kill people and in response, they were arrested in their wheelchairs.

What the hell are we doing?

A very useful study demonstrating the non-inferiority of IDAC (1.5g/m2) consolidation compared to HIDAC (3g/m2) in patients aged 18-60 with AML

pubmed.ncbi.nlm.nih.gov/40552969/

excellent paper looking at molecular/cytogenetic features associated with hematologic progression of polycythemia vera!

www.nature.com/articles/s41...

Day 14 - days of venetoclax with HMA in new diagnosed AML

www.nature.com/articles/s41...

Day 13 - outcomes of patients with AML that receive a 2nd allo-HCT with active disease

www.nature.com/articles/s41...

Day 12 - risk factors for early death in APL

ashpublications.org/bloodadvance...

Day 11 - pre-clinical rationale for targeting BCL2/BCLxL and LCK1 in T-cell ALL by @canersaygin.bsky.social et al (and informed an ongoing study open at @uchicagocancer.bsky.social!)

pmc.ncbi.nlm.nih.gov/articles/PMC...