Excited to see that our study on context-specific transcription factors was named as one of 8 remarkable outputs of 2024 by the Swiss Institute of Bioinformatics.
05.08.2025 20:51 — 👍 2 🔁 2 💬 0 📌 0@skimhellmuth.bsky.social
Human Geneticist, Emmy Noether Group Leader at Helmholtz Munich & Dr. von Hauner Children‘s Hospital, University Hospital LMU Munich, Germany, Member of Die Junge Akademie
Excited to see that our study on context-specific transcription factors was named as one of 8 remarkable outputs of 2024 by the Swiss Institute of Bioinformatics.
05.08.2025 20:51 — 👍 2 🔁 2 💬 0 📌 0Great career opportunities in Cellular Genomics @sangerinstitute.bsky.social
Big data (human in vivo + in vitro) + AI to derive biological mechanisms at scale.
We are seeking a range of research expertise including spatial omics and perturbation at scale
🥳🌟🥳 Our very first PhD student defended her thesis yesterday!
Huge congratulations to 💫Dr. Sathya Darmalinggam💫 for a brilliant PhD defence 🎓!
It's been a privilege have Sathya in the lab and see her develop as an independent researcher, the lab and I couldn't be more proud🤩! #proudPI #WomenInSTEM
🥳🥳🥳Countless years in the making and there it is 🫶🏻
Exceptionally proud of my lab and especially Lance who was driving this project for the last years! 🏎️Thank you to all the fantastic collaborators ♥️ I hope everyone enjoys reading our little story! www.nature.com/articles/s41...
We are SO EXCITED to share our story @nature.com:
🧵1/
Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring.
This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease.
👉 Read here: rdcu.be/erD3b
Preprint on "Improving spliced alignment by modeling splice sites with deep learning". It describes minisplice for modeling splice signals. Minimap2 and miniprot now optionally use the predicted scores to improve spliced alignment.
arxiv.org/abs/2506.12986
📢 Just posted: Our preprint introducing SPC — Spectral Components — is now live on medRxiv!
Led by Dr. Ruhollah Shemirani and years in the making, this method offers a robust, scalable way to adjust for recent population structure in genomic analyses.
🔗 www.medrxiv.org/content/10.1...
1/9
As a post-GWAS analysis, ever thought about automatic haplotype testing @ each locus + test vs any number of traits?
👏 Amazing @dariushghasemi.bsky.social just released #Haplomics, a #Snakemake pipeline walking u all the way down to summary stats+clustering
www.medrxiv.org/content/10.1...
#statgen
If we want to connect genetic variation to disease, we need to move beyond baseline conditions. Our study shows that dynamic, context-specific regulation holds the key to understanding many unexplained GWAS signals. The preprint again:
www.biorxiv.org/content/10.1...
Out today from #HectorOrtega & #SethASharp A state of the art review on polygenic risk scores (#PRS) in diabetes. This is your #101 on what we currently know about them and their application to understanding disease heterogeneity & clinical translation.
Read for free here - rdcu.be/eprel
We have updated our preprint about 850,000 person UK-Danish haplotype sharing - sheding light on the rich history each person carries with them in their DNA and comparing this to historical records. Xiaolei Zhang postdoc in my group led this work. www.biorxiv.org/content/10.1...
04.06.2025 22:17 — 👍 33 🔁 10 💬 1 📌 1We have an attractive opening for a tenure-track professorship in Single-Cell Systems Biology. Excellent package and infrastructure at @uni-wuerzburg.de Institute of Systems Immunology. Great place to live and work in the heart of the franconian wine region!
jobs.sciencecareers.org/job/673667/j...
We have 2-3 group leader positions opening @fimm-uh.bsky.social !!
We are looking for outstanding candidates in human genetics and precision medicine.
This time we have a focus on population health data science. E.g. AI for EHR/health data
Generous starting package 💰
shorturl.at/FAk6n
Nature’s careers team spoke to a dozen scientists who have been laid off from US federal agencies and from universities because of federal funding cuts in the past two months. #Academicsky 🧪
01.06.2025 01:12 — 👍 77 🔁 37 💬 1 📌 0What makes Helmholtz Munich's research unique?
At #HelmholtzMunich, our research is focused on detecting diseases earlier and preventing their progression, with the support of #AI, #genomics & #bioengineering.
👉 t1p.de/cgbwh
@www.helmholtz.de
#PersonalizedMedicine #Prevention #AI #bioengineering
Wow, so cool!🌟
Excellence in Nucleic Acid Sciences and Technologies: NUCLEATE Cluster selected for national recognition
Led by spokesperson Veit Hornung, the NUCLEATE Cluster secures funding in Germany’s Excellence Strategy
🥂🥳🤩
www.lmu.de/en/newsroom/...
@v-hornung.bsky.social