Sarah Kim-Hellmuth's Avatar

Sarah Kim-Hellmuth

@skimhellmuth.bsky.social

Human Geneticist, Emmy Noether Group Leader at Helmholtz Munich & Dr. von Hauner Children‘s Hospital, University Hospital LMU Munich, Germany, Member of Die Junge Akademie

52 Followers  |  114 Following  |  1 Posts  |  Joined: 31.05.2025  |  1.4491

Latest posts by skimhellmuth.bsky.social on Bluesky

Excited to see that our study on context-specific transcription factors was named as one of 8 remarkable outputs of 2024 by the Swiss Institute of Bioinformatics.

05.08.2025 20:51 — 👍 2    🔁 2    💬 0    📌 0

Great career opportunities in Cellular Genomics @sangerinstitute.bsky.social

Big data (human in vivo + in vitro) + AI to derive biological mechanisms at scale.

We are seeking a range of research expertise including spatial omics and perturbation at scale

01.08.2025 11:02 — 👍 7    🔁 6    💬 0    📌 0
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🥳🌟🥳 Our very first PhD student defended her thesis yesterday!
Huge congratulations to 💫Dr. Sathya Darmalinggam💫 for a brilliant PhD defence 🎓!
It's been a privilege have Sathya in the lab and see her develop as an independent researcher, the lab and I couldn't be more proud🤩! #proudPI #WomenInSTEM

24.07.2025 04:46 — 👍 6    🔁 0    💬 0    📌 0
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Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease - Nature Neuroscience The dynamics of microglia states adjacent to or far from amyloid-beta plaques are unclear. Here the authors show that non-plaque-associated microglia modulate the cell population expansion in response...

🥳🥳🥳Countless years in the making and there it is 🫶🏻
Exceptionally proud of my lab and especially Lance who was driving this project for the last years! 🏎️Thank you to all the fantastic collaborators ♥️ I hope everyone enjoys reading our little story! www.nature.com/articles/s41...

14.07.2025 15:37 — 👍 16    🔁 6    💬 0    📌 1
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Kupffer cell programming by maternal obesity triggers fatty liver disease Nature - In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.

We are SO EXCITED to share our story @nature.com:
🧵1/
Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring.
This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease.
👉 Read here: rdcu.be/erD3b

18.06.2025 16:41 — 👍 73    🔁 25    💬 2    📌 8
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Preprint on "Improving spliced alignment by modeling splice sites with deep learning". It describes minisplice for modeling splice signals. Minimap2 and miniprot now optionally use the predicted scores to improve spliced alignment.
arxiv.org/abs/2506.12986

17.06.2025 01:48 — 👍 108    🔁 54    💬 0    📌 1
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SPC: a SPectral Component approach to address recent population structure in genomic analysis Population structure is a well-known confounder in statistical genetics, particularly in genome-wide association studies (GWAS), where it can lead to inflated test statistics and spurious associations...

📢 Just posted: Our preprint introducing SPC — Spectral Components — is now live on medRxiv!

Led by Dr. Ruhollah Shemirani and years in the making, this method offers a robust, scalable way to adjust for recent population structure in genomic analyses.
🔗 www.medrxiv.org/content/10.1...

1/9

17.06.2025 16:26 — 👍 36    🔁 15    💬 1    📌 0
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Haplomics: A Snakemake pipeline for haplotype-based association analysis in multi-omics studies Summary Genome-wide association studies (GWAS) generated thousands of loci associated with complex traits and diseases. However, to characterize of the pleiotropic, molecular and population genetic bo...

As a post-GWAS analysis, ever thought about automatic haplotype testing @ each locus + test vs any number of traits?
👏 Amazing @dariushghasemi.bsky.social just released #Haplomics, a #Snakemake pipeline walking u all the way down to summary stats+clustering
www.medrxiv.org/content/10.1...
#statgen

13.06.2025 07:11 — 👍 6    🔁 5    💬 1    📌 0
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Disease-associated loci share properties with response eQTLs under common environmental exposures Many of the genetic loci associated with disease are expected to have context-dependent regulatory effects that are underrepresented in the transcriptomes of healthy, steady-state adult tissues. To un...

If we want to connect genetic variation to disease, we need to move beyond baseline conditions. Our study shows that dynamic, context-specific regulation holds the key to understanding many unexplained GWAS signals. The preprint again:

www.biorxiv.org/content/10.1...

10.06.2025 14:20 — 👍 23    🔁 11    💬 1    📌 0
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Out today from #HectorOrtega & #SethASharp A state of the art review on polygenic risk scores (#PRS) in diabetes. This is your #101 on what we currently know about them and their application to understanding disease heterogeneity & clinical translation.

Read for free here - rdcu.be/eprel

04.06.2025 23:22 — 👍 9    🔁 6    💬 0    📌 0
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Population-scale inheritance analysis of 858,635 individuals reveals North Sea migration from the Middle Ages to the Industrial Revolution The North Sea's historical migrations have impacted the genetic structure of its neighbouring populations. We analysed haplotype sharing among 858,635 modern individuals from Denmark and Britain to in...

We have updated our preprint about 850,000 person UK-Danish haplotype sharing - sheding light on the rich history each person carries with them in their DNA and comparing this to historical records. Xiaolei Zhang postdoc in my group led this work. www.biorxiv.org/content/10.1...

04.06.2025 22:17 — 👍 33    🔁 10    💬 1    📌 1
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junior professorship position (f/m/d) in Single-Cell Systems Biology - Würzburg (Stadt), Bayern (DE) job with Julius-Maximilians-University Würzburg - Faculty of Medicine | 673667 The Julius-Maximilians-University Würzburg, Faculty of Medicine is offering one junior professorship position (f/m/d) in Single-Cell Systems Biology.

We have an attractive opening for a tenure-track professorship in Single-Cell Systems Biology. Excellent package and infrastructure at @uni-wuerzburg.de Institute of Systems Immunology. Great place to live and work in the heart of the franconian wine region!

jobs.sciencecareers.org/job/673667/j...

02.06.2025 09:29 — 👍 10    🔁 15    💬 0    📌 1
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FIMM-EMBL Group Leaders in Molecular Medicine FIMM-EMBL Group Leaders in Molecular Medicine

We have 2-3 group leader positions opening @fimm-uh.bsky.social !!

We are looking for outstanding candidates in human genetics and precision medicine.

This time we have a focus on population health data science. E.g. AI for EHR/health data       

Generous starting package 💰

shorturl.at/FAk6n

01.06.2025 15:38 — 👍 38    🔁 45    💬 0    📌 1
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#OpenToWork: how laid-off US scientists are coping with shattered careers Unemployed researchers face some tough career choices as they flood the job market after the Trump administration’s cuts to science.

Nature’s careers team spoke to a dozen scientists who have been laid off from US federal agencies and from universities because of federal funding cuts in the past two months. #Academicsky 🧪

01.06.2025 01:12 — 👍 77    🔁 37    💬 1    📌 0
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What makes Helmholtz Munich's research unique?

At #HelmholtzMunich, our research is focused on detecting diseases earlier and preventing their progression, with the support of #AI, #genomics & #bioengineering.

👉 t1p.de/cgbwh

@www.helmholtz.de
#PersonalizedMedicine #Prevention #AI #bioengineering

19.05.2025 08:32 — 👍 3    🔁 2    💬 0    📌 0
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NUCLEATE Cluster of Excellence: beacon of nucleic acid research The new NUCLEATE Cluster of Excellence is all about nucleic acids. The research alliance seeks to better understand their various functions and open up new areas of application.

Wow, so cool!🌟
Excellence in Nucleic Acid Sciences and Technologies: NUCLEATE Cluster selected for national recognition
Led by spokesperson Veit Hornung, the NUCLEATE Cluster secures funding in Germany’s Excellence Strategy
🥂🥳🤩
www.lmu.de/en/newsroom/...
@v-hornung.bsky.social

22.05.2025 18:05 — 👍 20    🔁 7    💬 0    📌 0

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