mattgroeschel.bsky.social

In this 60-Second Journal Club, NEJM Editorial Fellow Abarna Pearl, MD, MPH, summarizes the BALANCE trial comparing antibiotic treatment for 7 versus 14 days in patients with bloodstream infections. Read the full article and accompanying Research Summary: nej.md/3Z5bTJD

#MedSky #IDSky

Come and work with me and use the 53,897 samples of M. tuberculosis we have collated to help tackle this important disease!

We are part of the OxCoD4TB consortium that is developing new therapeutics for tuberculosis.

Grade 7, funding until 28 Feb 2028, deadline noon Fri 4 July

bit.ly/4ndKOhF

congrats Jody!

Changes to the 2026 and 2027 Work Programmes With the launch of the competitions for grants under ERC Work Programme 2026 in July of this year, several changes to the submission of applications and the evaluation of proposals will apply. The mai...

Important changes on @erc.europa.eu grants‼️Grant structure & most importantly eligibility timeframes (10 years for starting, 15 years for consolidator post PhD-but you can have them only once) changes: erc.europa.eu/news-events/...

Cumulative event curves for a sustained QFT test conversion (primary efficacy end point) according to trial visit.

𝘔𝘺𝘤𝘰𝘣𝘢𝘤𝘵𝘦𝘳𝘪𝘶𝘮 𝘵𝘶𝘣𝘦𝘳𝘤𝘶𝘭𝘰𝘴𝘪𝘴 continues to cause substantial illness globally. In this phase 2b randomized trial, BCG revaccination did not prevent sustained 𝘔. 𝘵𝘶𝘣𝘦𝘳𝘤𝘶𝘭𝘰𝘴𝘪𝘴 infection in IGRA-negative, HIV-negative adolescents. Full BCG REVAX trial results: nej.md/3GKdPkf

#MedSky #IDSky

heerlijk

congrats Peter and team

Book Review: ‘Everything Is Tuberculosis,’ by John Green In a new nonfiction book, the Y.A. novelist describes the disease as a window into “the folly and brilliance and cruelty and compassion of humans.”

New review of "Everything Is Tuberculosis" in the @nytimes.com, which calls the book "earnest and empathetic," which is really all I wanted it to be. (And also all I want to be.) www.nytimes.com/2025/03/20/b...

It’s the world’s most deadly infectious disease. But it strikes the world’s most downtrodden and neglected, including here at home. So we turn our eyes.

Not you, @johngreensbluesky.bsky.social. You’ve made the story of TB personal. And your vivid, moving, vital book makes us grateful you did.

As screenshot showing the title of the study "Safety and effectiveness of MVA-BN vaccination against mpox in at-risk individuals in Germany (SEMVAc and TEMVAc): a combined prospective and retrospective cohort study" a and two graphs illustrating the Vaccine effectiveness in the overall cohort and in sub-cohorts.

Out now in @thelancetinfdis.bsky.social our study demonstrates that the MVA-BN (Imvanex/Jynneos) vaccine is safe & effective against mpox, but a single dose does not sufficiently protect people living with #HIV.
Thank you @ema.europa.eu for support
www.thelancet.com/journals/lan...
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Masern: So gefährlich ist das Geschehen in den USA Die Masern sind eine der gefährlichsten Infektionskrankheiten. In den USA gibt es nun einen großen Ausbruch. Warum uns das auch in Deutschland interessieren muss.

Gerade breiten sich Maserninfektionen wieder in den USA aus & es gibt wieder Todesfälle. Auch in 🇩🇪 gibt es weiter viele Masernfälle. Dabei ist die MMR Impfung die vielleicht beste & effektivste Impfung aller Zeiten.
Meine Gedanken zu Masern, Impf- u Wissenschaftsskepsis in der @faznet.bsky.social

Love it! Time to move beyond SNP clustering = transmission. Although important to not forget host infectiousness, exposure time and contact susceptibility in the equation next to pathogen genomes

see, this plane got measles and was perfectly fine

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Hello, Bluesky!👋 We are excited to connect with you!🌟
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🚨 Groundbreaking study reveals how hypoxia shapes immune cell organization in #Tuberculosis granulomas, promoting Mtb persistence. Targeting these metabolic niches could revolutionize TB treatment strategies. A technical tour de force and a major scientific advance!
📖 shorturl.at/WkTgq

While the US trashes public research, the ERC proposes to double its budget. That would be huge and an excellent opportunity for scientists in the US to come to democratic 🇪🇺

‚Gaps in TB funding could lead to increased transmission globally.‘ Rapid communication from StopTB on the impact of foreign aid freeze.

We'll try and keep the political posts to a minimum. That said; the only way to defend our wildlife is to become active politically and go after the politicians going after our parks.

Get in this fight, retweet it and follow us at
@altyellonatpark.org

Because it's a world worth saving

congrats Jeff

Get a first look at the exciting IAS 2025 speaker lineup! Join us this July in Kigali!

Friendly reminder that tuberculosis isn’t an “1800s disease” and is in fact THE infectious disease that kills the most people in the 21st century. It is preventable, treatable, and curable, and yet it still kills over 1.2 million people a year because we don’t put the resources where the disease is.

Important lessons from South Africa on screening contacts of active TB: ‚more than 80% of confirmed TB cases among HHC were asymptomatic. CXR screening missed more than 40% of these asymptomatic cases‘

Great that your book will be available in German.

Big Change in TB treatment recommendations. 6 months of RIPE (also called RHEZ) was once the only treatment in town for susceptible TB. Now there's an all oral FOUR months of:
Rifapentine
INH
PZA
Moxifloxacin
t.co/8EHiWEhEk8

are there studies looking into co-prevalence of leprae and TB?

Immunopeptidomics (impep) friends, have you ever done impep to ID peptides after soluble protein delivery to phagocytes to look at peptides generated by XP?

HIV-Forschung: Kurz vor der Heilung? Einst bedeutete Aids den Tod, heute ist es eine gut behandelbare Erkrankung. Aber heilen lässt sie sich noch nicht. In Berlin will man das ändern.

HIV - Heilung in Sicht?
Sehr informativer und differenzierter Artikel in der @taz.de über die Fortschritte und Herausforderungen in der HIV-Forschung & Therapie und der Lange Weg zur Heilung.
@cgaebler.bsky.social gibt spannende Einblicke in seine Forschung an der Klinik f. Infektiologie #Charité

Interesting study showing several host RNA signatures poorly generalized to a new cohort predicting sputum conversion at 8 weeks.

Yes, transmission is challenging to quantify both through epi-links (recall) and these packages, good to see how these methods are improved. Thanks for your work in this area