Marco Silva

Essential redundancies fuel Mycobacterium tuberculosis adaptation to the host Redundancy in biology is, at a glance, counterintuitive because if the function of two gene products completely overlaps then, throughout the course of evolution, one of the genes will likely accumula...

Mycobacterium tuberculosis is an outlier in many ways. One of them is keeping a high degree of functional redundancy despite its obligate pathogen lifestyle. In this review, we reflect on the biological meaning of M. tuberculosis functional redundancies.

journals.plos.org/plospathogen...

07.12.2025 12:07 — 👍 33    🔁 14    💬 1    📌 1

The Mycobacterium tuberculosis long-chain fatty acid resistome reveals the universal stress protein TB15.3 as essential for infection The human pathogen Mycobacterium tuberculosis (Mtb) thrives in lipid-rich microenvironments. Long-chain fatty acids (LCFA) are some of the most abundant lipids encountered by Mtb during infection. Mtb...

Long-chain fatty acids can be carbon sources for pathogens but are also potent antimicrobials. In our latest work, we explored the question of how Mycobacterium tuberculosis avoids getting killed by a preferred carbon source.

www.biorxiv.org/content/10.1...

15.04.2025 06:30 — 👍 8    🔁 4    💬 0    📌 1

The Mycobacterium tuberculosis long-chain fatty acid resistome reveals the universal stress protein TB15.3 as essential for infection https://www.biorxiv.org/content/10.1101/2025.04.14.648703v1

15.04.2025 04:16 — 👍 9    🔁 4    💬 1    📌 1

It was really great hosting you @oneyrolles.bsky.social! Fantastic science, great conversations, and a truly enjoyable time. Glad you had a great experience!

22.02.2025 17:31 — 👍 3    🔁 0    💬 0    📌 0

Huge thanks to @marcopsilva.bsky.social, Thales Costa and all the students for the kind invite to speak at the @i3suporto.bsky.social Student symposium! 🌟
Top-notch organization, amazing vibes, and a truly warm welcome, an unforgettable experience! 🙏
#i3Ssymposium

21.02.2025 15:01 — 👍 8    🔁 4    💬 0    📌 1

First time at #EMBOtuberculosis presenting a part of my PhD work through a flash talk and poster presentation. Great to finally meet the TB community! Incredible experience in India, with amazing science, wonderful people, and delicious food! 🇮🇳

12.02.2025 19:17 — 👍 5    🔁 1    💬 1    📌 0

What a great conference #EMBOtuberculosis has been! Amazing science, amazing food and a very friendly community! And it was a pleasure to share the work we’re developing at i3S U. Porto.

12.02.2025 10:24 — 👍 13    🔁 3    💬 1    📌 0

Introducing my wonderful team at i3S - University of Porto. PhD student @marcopsilva.bsky.social and research fellow @alexjpinto.bsky.social

17.11.2024 13:46 — 👍 9    🔁 5    💬 2    📌 0