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Exciting news!
Our new paper on ancient mtDNA from Iron Age NE Iberians is now published in #JournalOfArchaeologicalScience! 🧬
Huge thanks to co-authors & @GREAB_UAB, @uabbiociencies, and @UABBarcelona 🙏
Read it here 👉 doi.org/10.1016/j.ja...
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4/ A huge thank you to my co-authors @crisamorjimenez.bsky.social, and @cmpereirasantos.bsky.social! 🙌
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3/ We compared the damage profile with mutational hotspots and heteroplasmic positions and found that 2,781 positions had not been previously reported in any of those profiles.
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Distribution of the 2933 hotspots identified in the present study. These hotspots exhibit a percentage exceeding 23.8% and collectively represent the top 25% of the positions with the highest values. The non-coding region is highlighted in red, while an orange line denotes the origin of replication. Region of the mitogenome with < 30 reads covering them in at least 75% (321 samples) of those analysed are shaded in blue to indicate their absence in our profile.
2/ Using 427 non-UDG-treated ancient samples from NGS data, we created a comprehensive molecular damage profile for ancient mtDNA, identifying 2,933 damage hotspots across the human mitogenome (out of 11,735 evaluated positions).
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