Shanon Rego

The Da Mesquita Lab turned 5! Kudos to all present & past members!
@lilianacorreia.bsky.social @shanonrego.bsky.social @sanchezlulu.bsky.social
Virginia, Patty, Parul, Rae, Megan, Nicole & Sofia 🤩😍
It is your creativity, intelligence & hard work that make it all worth it. Here’s to another 5!!! 🎉🍾🥂

Celebrating the 1st successful postdoctoral fellowship application from the lab! Liliana (@lilianacorreia.bsky.social) was awarded the NACC & @alzassociation.bsky.social New Investigator Award! On top of doing fantastic research, Lili is also an amazing colleague! We are all very proud of her! 😁🎉🍾🥂

Bluesky plant people!
My patio has potential…right now it’s just hot and sad :/
What would you add to bring it to life?
#PlantsofBluesky #PatioPlants #GardeningInspiration #SmallSpaceGardening

Yet another amazing annual Mayo Clinic Neuroscience Departmental Retreat! Tons of exciting new research avenues and scientific breakthroughs! 😁🧠🔬🤓

Read our latest review article out in @thelancetneuro.bsky.social if you want to know more about CSF transport across the different compartments of the brain-meningeal border and its importance for neurological diseases with strong neuroimmune components 😉
authors.elsevier.com/a/1l7l75FFzL...

Interleukin-34-dependent perivascular macrophages promote vascular function in the brain The niche signals critical for the homeostasis and functions of the brain border-associated macrophages (BAMs) are not well understood. Van Hove et al. demonstrate that BAMs require IL-34 derived from mural cells and perivascular fibroblasts for their maintenance in adulthood. They show that BAMs are required to promote normal vascular function in the brain.

Online now: Interleukin-34-dependent perivascular macrophages promote vascular function in the brain

Very cool to see that the field has now (at least) one mechanism for the phenomena we reported in 2018 & 2021:

www.nature.com/articles/s41...

www.nature.com/articles/s41...

Go @jonykipnis.bsky.social and team! 💪🏻👏🏻👍🏻

One step closer to understanding how meningeal lymphatics affect brain immunity! 😃

strain #000664
IYKYK

Our Sleep, Brain Aging, and Waste Clearance How sleep prevents "dirty" brains that age faster

Publications in the past week built substantially on our knowledge of the brain's waste disposal system—glymphatics—and the implications on sleep and brain aging.
Featuring exceptional work by Nedergaard Lab and @jonykipnis.bsky.social
erictopol.substack.com/p/our-sleep-... open-access

Having an amazing time here at Mayo Phoenix!

So many cool investigators, students, and resources :)

Added benefit of those mountains 🫶🏼

The anatomy of brainwashing. #Science

www.science.org/doi/10.1126/...

Extrasinusoidal dural macrophages are a distinct subset of immunologically active central nervous system–associated macrophages
www.science.org/doi/10.1126/...
@sciimmunology.bsky.social

The SARS-CoV-2 spike protein can persist in the brain—in the skull bone marrow and meninges—to induce neurologic damage
www.cell.com/cell-host-mi... open-access

Here is a starter pack on the #Meninges, #CSF, and #Glymphatics. Please share and let me know if you should be on the list and I will add you! go.bsky.app/NLcabwc

Do you study 🧠 barriers & neurovasculature? We still have room in this starter pack, reply here if you are not added already.

Want to follow 🤩 scientists studying the BEST cell types & structures in the CNS (ok, besides neurons, glia, etc)? Click the 'Follow All' button in the top right corner. 😉

New to 🦋
I’m a first year Neuro PhD student @mayoclinic.bsky.social. My background is in meningeal lymphatics and neuroimmunology. My broad interests are in understanding the neuroimmune interactions in “homeostasis” and diseases like AD, epilepsy, TBI, SCI, among others!

Done! go.bsky.app/RB6RXKy