Cyril Mousseaux

We uncovered a powerful type I interferon signature in #ANCA #vasculitis, especially in MPA, tied to kidney prognosis, and close to lupus nephritis. 🚀 This opens exciting perspectives for IFN–targeted therapies in vasculitis. Full results presented at #KidneyWk @asnkidney.bsky.social in a few hours!

YouTube video by Allo Docteurs Lavement au café : attention aux effets secondaires de cette nouvelle tendance détox

Depuis la rentrée, j'ai une nouvelle casquette ! Je suis chroniqueuse dans le Mag de la santé sur France 5. A chaque fois, je démêle le vrai du faux de pratiques désignées comme alternatives. En voici une de la famille détox : le lavement au café ! Un conseil, continuez de le boire par le haut... ☕

Horisberger et al separate Lupus nephritis patients in 3 groups by blood:
healthy-like, interferon-dominant and CD8 T cell-dominant.
The CD8 T cell-dominant group had the highest biopsy activity score and highest response rate after 1 year; the healthy-like the most chronic damage. 🧪 ⑂ #NephSky
1/

Pregnancy-associated acute kidney injury — consensus report of the 32nd Acute Disease Quality Initiative workgroup - Nature Reviews Nephrology Pregnancy-associated acute kidney injury is a risk factor for maternal and fetal morbidity and mortality and a driver of health inequity worldwide. This Consensus Statement from the Acute Disease Quality Initiative provides recommendations on the causes, diagnosis, management and follow-up of pregnancy-associated acute kidney injury.

Super proud to be part of this magical team led by ravindra mehta and marlies osterman marshalling us all to come up with these consensus statements about pregnancy associated acute kidney inhury PrAKI www.nature.com/articles/s41...

Awesome infographic on genetic testing in ADPKD by Neera Dahl, @pranavgarimella.bsky.social and Fouad Chebib www.kidneynews.org/view/journal...

Great quizz!

#Quiz from January 2022:

A 57-year-old woman presented with severe hypokalemia; the electrocardiogram showed sinus arrhythmia, flattened T waves, and prolonged QT interval of 667ms.

How should this patient be treated?

bit.ly/3pFr8au (FREE)

Very nice practical summary article

Amazing how far we have come with understanding the genetics behind Alport Syndrome and much of what we used to call “Thin Basement Membrane Disease”

> il faut des cardiologues avec de l'expérience et de l'expertise du sujet. Tous les cardiologues ne sont pas "insuffisant cardiologues" tout comme tous les cardiologues ne sont pas coronarographistes.

Challenging the narrative of alport syndrome spectrum: no link with cystic phenotype AbstractBackground. Alport Syndromes (AS) are the second leading genetic cause of Kidney Failure (KF). Whether multiple kidney cysts (MKC) phenotype belong

The proof is in the data: academic.oup.com/ndt/advance-...
Cysts are not caused by Alport syndrome, though patients with Alport syndrome can have cysts.

Anticoagulant-related nephropathy MINI-REVIEW Anticoagulant-related nephropathy Authors Irene Martin1, Paolo Nikolai So2, Tiffany Caza3, Mohamed Hassanein4 Affiliation 1 Hospital Universitario 12 de Octubre, Madrid, Sp...

Nice review @glomcon.org
#MedSky #NephSky

pubs.glomcon.org/anticoagulan...

Clinical Spectrum and Prognosis of Atypical ADPKD Caused by Monoallelic Pathogenic Variants of IFT140

https://bit.ly/4h1uEDV

#VisualAbstract

Traitement diurétique de l’insuffisance cardiaque Associés aux digitaliques, les diurétiques ont été longtemps le seul traitement de l’insuffisance cardiaque. L’efficacité était modeste, la mortalité des patients présentant une insuffi…

bumetanide + acetazolamide + MRA is my prefered option by oral route

torsemide is not available in France ; The oral bioavailability of bumetanide is better than that of furosemide

more here (in french)
insuffisantcardiologue.com/2023/03/13/t...

US Abortion Bans and Infant Mortality This population-based, cross-sectional study investigates the infant mortality rate following the adoption of complete or 6-week abortion bans in a number of US states.

L'interdiction des avortements aux USA s'accompagne d'une augmentation de la mortalité infantile de 5% soit 478 décès supplémentaires en qq mois. Ceci touche en premier les populations les plus fragiles. jamanetwork.com/journals/jam...

Figure 2. Sodium Content on Packaging in a Basket of Food Products in the Agincourt-Bushbuckridge by Wave and Legislative Target

From JAMA Cardiology:

South African regulations limiting sodium in processed foods were associated with reductions in sodium consumption and blood pressure among rural adults aged 40 years or older.

ja.ma/4hMWyUW

#CardioSky

Every week, I see a new study talking about this or that effect of GLP-1 receptor agonists like #ozempic. FINALLY, we have a study evaluating all the outcomes (good and bad) in one dataset. There are some... surprises. 🧵

Exon location of glycine substitutions impacts kidney survival in autosomal dominant Alport Syndrome - PubMed Our results confirm that ADAS can lead to ESKD. We demonstrated that a glycine substitution involving the distal exons had a negative impact on renal survival in ADAS patients, probably due to a trime...

A glycine substitution involving the distal exons had a negative impact on renal survival in patients with autosomal dominant #Alport syndrome. pubmed.ncbi.nlm.nih.gov/39810285/

Estimated potassium intake and the progression of chronic kidney disease AbstractBackground and hypothesis. Lower potassium intake is associated with a higher risk of chronic kidney disease (CKD) in the general population. Howev

Most kidney disease patients are still advised the OPPOSITE.
Important to know:
Low potassium intake is associated with worse CKD progression.

academic.oup.com/ndt/advance-...

Update- transdermal mGFR system is now FDA approved…

www.medibeacon.com/medibeacon-t...

Early Thrombotic Microangiopathy #TMA After #ABOIncompatible Living Donor Kidney Transplantation #LDKT

#VisualAbstract by @NephroSeeker

www.kireports.org/ar...

ICU Studies - Refresher:

Are you using the IVC diameter to "predict" if an ICU patient is "fluid responsive" (FR)?

This was an important multi-center descriptive study conducted during a 2-yr period in 5 French ICUs

540 ventilated patients w shock of various origins underwent

#Oxalatenephropathy associated with glyoxylate-containing hair-straightening products: a call for caution

doi.org/10.1016/j.kint.2024.09.015

Original article: doi.org/10.1016/j.kint.2024.07.032

#KICommentary #aki #acutekidneyinjury

Chronic Hyponatremia and Brain Structure and Function Before and After Treatment

https://bit.ly/3ZpTbLX

#VisualAbstract #OpenAccess

Oui fort heureusement !

Deaths Related to Coffee Enemas NATUROPATHIC therapies are increasing in popularity in the United States, and many of them rely primarily on alterations in diet. Although diet and nutrition are recognized as important adjuncts in ca...

Je ne penserai pas qu'on en parlerai un jour sur le ciel bleu. On a malheureusement eu deux patients hospitalisés en nephrologie il y a qq années avec ce type de lavement avec des insuffisances renales avec cristaux d'oxalate de calcium. Sans parler des rectites. jamanetwork.com/journals/jam...

Patient with severe heart failure getting nuclear-powered diuresis when the creatinine goes down: the kidneys are perfusing better, continue diuresis

Patient with severe heart failure getting nuclear-powered diuresis when the creatinine goes up: that’s just hemoconcentration, continue diuresis

Quand la néphrotoxicité du méthotrexate se voit au microscope 🔬
▶ Methotrexate Crystals on Electron Microscopy of Kidney Biopsy for Acute Kidney Injury

A list of #NephTwitter #NephJC followers and supporters

Small list but will be growing!

bsky.app/profile/did:...