SIN - Italian Society of Nephrology

The Mayo Imaging Classification of ADPKD description (left panel) and imaging examples (right panel) with examples (right panel) of (a, b) subclass 1A and 1E, (c-f) subclass 2A, and (g, h) subclass 2B. Abbreviations: ADPKD, autosomal dominant polycystic kidney disease; TKV, total kidney volume. Reproduced with permission of the copyright holder (Kidney Disease: Improving Global Outcomes) from Kidney Disease: Improving Global Outcomes (KDIGO) ADPKD Work Group. KDIGO 2025 Clinical Practice Guideline for the Evaluation, Management, and Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD). Kidney Int. 2025;107(suppl 2S):S1-S239. doi:10.1016/j.kint.2024.07.009

Core Curriculum by Craig E. Gordon et al:

Autosomal Dominant Polycystic Kidney Disease: Core Curriculum 2025
bit.ly/465twwK (FREE)

Excellent thread below

I will also plug this talk by Paola Romagnani on podocytopathies

youtu.be/bRMeqaGgA9I?...

#GlomCon #NephGR

𝗧𝗢𝗗𝗔𝗬: ISN Webinar: "Optimizing RAASi Therapy in Clinical Practice: A Case-Based Discussion."


🗓️ September 17
🕓 4 pm CEST
🔗 Free registration: http://lite.spr.ly/6...

This webinar is supported by @astra-zeneca.bsky.social and CSL Vifor

📣 Registration for #ISNWCN 2026 is open. This is your chance to be part of the leading global congress on kidney care!
✔️ Register early with exclusive discounted rates
✔️Apply for a travel grant
We can’t wait to welcome you in Yokohama! Secure your spot today ➡️http://lite.spr.ly/6...

Horisberger et al separate Lupus nephritis patients in 3 groups by blood:
healthy-like, interferon-dominant and CD8 T cell-dominant.
The CD8 T cell-dominant group had the highest biopsy activity score and highest response rate after 1 year; the healthy-like the most chronic damage. 🧪 ⑂ #NephSky
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Weekend Briefing for September 6, 2025:

New Images in Clinical Medicine: Acute Epididymo-orchitis in IgA Vasculitis nej.md/4m4UJV0

Five New Perspectives:

1️⃣ Caring for Patients with IDDs nej.md/47YdUfB

Visual abstract

How common is kidney failure with MCD and FSGS?

More than we think … @brianrifkin.bsky.social breaks down the recent @asnpublications.bsky.social JASN paper from the RaDaR study www.nephjc.com/news/nephjc-...

New in #ASNJASN and at #Hypertension25: In a randomized, double-blind, placebo-controlled trial, Baxdrostat reduced systolic blood pressure in patients with CKD and uncontrolled hypertension. Read more about its safety and efficacy in patients with CKD here: kidney.pub/JASN0849

Efficacy and Safety of Baxdrostat in Participants with CKD and Uncontrolled #Hypertension: A Randomized, Double-Blind, Placebo-Controlled Trial ca. 2025 from @asnpublications.bsky.social @escardio.bsky.social
#Nephpearls #NephSky #ESCCongress

👉 journals.lww.com/jasn/fulltex...

@nephjc.bsky.social @lastwalsh.bsky.social just presented ACHIEVE results at #ANZSN. Here’s a some details of country differences not in the main paper

How do you treat challenging cases of antibody-mediated glomerular diseases? This #ASNCJASN article explains the options, their efficacy, and possible future directions for care. kidney.pub/CJASN0843

SGLT2 Inhibitors and GLP-1 Receptor Agonists in Kidney... : Transplantation ovascular and kidney benefits in non-KT recipients, but evidence in KT recipients remains limited. This systematic review and meta-analysis provide updated evidence on the efficacy and safety of SGLT2...

>7.000 kidney transplant recipients
on SGLT2 inhibitors & GLP-1RAs

▶️ better survival, cardiovascular & kidney outcomes, weight loss, lower HbA1c

no safety risks
tinyurl.com/4p6fdybn

The ISN Rare Kidney Diseases Toolkit offers concise, expert-led guidance to support timely recognition and informed decision-making in complex cases. Check out our latest tool on ADPKD and explore even more resources in the toolkit.

http://lite.spr.ly/6...

#NephJC Summer Bookclub: Everything is Tuberculosis by John Green — NephJC The summer book club started in 2015 , with one of the best books we have done in book club, Atul Gawande's Being Mortal . I think it should be required reading for all physicians. So now, in 2025, ...

It's finally here!!
#NephJC summer book club 📚
Everything is Tuberculosis by @johngreensbluesky.bsky.social
8/19/25 @ 9pm EST
Come for the discussion, stay for stories.
www.nephjc.com/news/2025/8/...

#Quiz from January 2022:

A 57-year-old woman presented with severe hypokalemia; the electrocardiogram showed sinus arrhythmia, flattened T waves, and prolonged QT interval of 667ms.

How should this patient be treated?

bit.ly/3pFr8au (FREE)

Histogram showing distribution of time from diagnosis of systemic sclerosis to scleroderma renal crisis in the late-onset group

Among 223 patients with scleroderma renal crisis, 24% were late-onset (>5 years), with mean onset 12 years after initial diagnosis of systemic sclerosis. Exposure to steroids was significantly associated with late-onset scleroderma renal crisis

AC&R
doi.org/10.1002/acr....

#Medsky #Nephsky

The Columbia Renal Biopsy Course 2025 starts tomorrow! Don’t forget to register using the following link: web.cvent.com/event/...

📝 Want your abstract to stand out?

Join our webinar on 5 Aug to sharpen your abstract writing – perfect for QI, qualitative, mixed-methods & clinical trials.

✅ Expert tips
✅ Q&A
✅Practical resources

📅 Save the date

📥Submit to #UKKW26 by 19 Sept!
www.ukkw.org/abstracts

A figure showing the changes from baseline in systolic blood pressure (SBP), plasma aldosterone–renin ratio (ARR), and serum potassium level for each patient.

In 15 patients with primary aldosteronism, baxdrostat (a second-generation, nonimidazole aldosterone synthase inhibitor) resolved or reduced the severity of hypertension, excessive aldosterone production, and hypokalemia. Full SPARK study results: nej.md/40Js1kz

#ENDO2025

Galileo—an Artificial Intelligence tool for evaluating pre-implantation kidney biopsies - Journal of Nephrology Background Pre-transplant procurement biopsy interpretation is challenging, also because of the low number of renal pathology experts. Artificial intelligence (AI) can assist by aiding pathologists wi...

Interpreting pre-transplant kidney biopsies just got smarter! Galileo AI tool is showing incredible promise. It's not just faster (2 mins!), but also reduces variability in critical assessments. #HealthcareInnovation #AI #TransplantMedicine link.springer.com/article/10.1...

Alport Syndrome Outcomes Linked to Genotype and Proteinuria in RaDaR Study A RaDaR analysis from ERA 2025 provides insight into predictors of disease progression, outcomes in patients with Alport syndrome.

🎥 New RaDaR data on #AlportSyndrome

✅ 1175 patients
✅Key for understanding disease progression
✅ Informs future trial design

RaDaR's Danny Gale discusses the most detailed AS analysis yet.

🎥Watch the HCP Live News interview: ow.ly/xo7150WbFcY

#RareKidneyDisease

📢 New from KDIGO: The 2025 Clinical Practice Guideline for the Management of Nephrotic Syndrome in Children is now available.
Covers updated recs on steroid-sensitive/resistant forms, biopsies, genetic test & more.
🔗 kdigo.org/guidelines/g...
#nephrology #pediatrics #glomerular #kidney

📊 A new study investigates the use of the Renal Resistance Index as a non-invasive tool to assess renal hemodynamics.
👉 Read the full article here: giornaleitalianodinefrologia.it/2025/04/42-0...

#RenalDisease #Nephrology #AKI #CriticalCare #DopplerUltrasound #Sepsis #IntensiveCare