Will Jin

I met a mentor early on in med school and she became my model for what success looked like. As she introduced me to the field, I couldn’t see myself doing anything else.

🥲 I think I’ve definitely caught myself saying this before.

This is very cool! Can you share details of the case? I am a huge mixed reality enthusiast.

American Science in Peril This Viewpoint discusses the importance of federal funding of biomedical research from the National Institutes of Health to scientific discovery, advancements in individual and public health, and the support of the US’ community of scientists.

Viewpoint: Recent disruptions and funding cuts at the NIH undermine the infrastructure and stability of US scientific research, threatening the nation's global leadership and scientific productivity. https://ja.ma/3FLvqHS

Congrats brother. Welcome to the best specialty!

How the NIH dominates the world’s health research — in charts (and what we stand to lose)
@nature.com @natureportfolio.nature.com
🧪

www.nature.com/articles/d41...

@nytimes.com the largest central of scientific knowledge in the world (Pubmed) and the NIH website is down.

I know it’s a tall ask but any insights?

These is largely taxpayer-funded research and it was available to all - and now it’s not.

Statement by Francis Collins, MD. PhD March 1, 2025 Yesterday I notified NIH Acting Director Matt Memoli, MD of my retirement from the federal government. effective February 28, 2025. The National Institutes of Health is the world's foremost medical research institution. It has been rightfully called the "crown jewel" of the federal government for decades. It has been the greatest honor of my life to be part of this institution in various roles over the last four decades. In the 1980s, NIH supported my work at the University of Michigan through a peer-reviewed grant. That led to the identification of the gene for cystic fibrosis. Thirty years later that has led to an almost miraculous treatment that allows most kids with cystic fibrosis to look forward to an almost normal life span. I was recruited to NIH in 1993 to lead the Human Genome Project - an extraordinarily bold initiative to read out the three billion letters of the human DNA instruction book. Funded by the U.S. Congress, the project completed its work -- two years ahead of schedule, and $400 million under budget. The success of the project, and the commitment to share all of the data rapidly and freely, has revolutionized every aspect of human biomedical research and medical practice. Subsequently I was honored to be asked to serve as the Director of the National Institutes of Health. I had the chance to serve three Presidents - Barack Obama, Donald Trump, and Joseph Biden. I also had the opportunity to work regularly with members of Congress in both parties. I loved those interactions and relationships. Throughout that time, investment

relieving human suffering, and contributing substantially to the U.S. economy. That consistent support made possible bold new projects in regenerative medicine, brain science, precision health, cancer, and solutions for opioid addiction, to name just a few. When the worst pandemic in more than a century arose in 2020, it was my job as Director of NIH to pull together partnerships with the FDA, academia, and the private sector to produce what only America's unparalleled biomedical sector could have: COVID vaccines in just 11 months, a staggering medical achievement that saved over three million lives in the U.S.alone. After a stint in the White House as the President's Acting Science Advisor, where I had the chance to organize a major initiative to eliminate hepatitis C in the United States, i returned to the intramural research program of the National Human Genome Research Institute in 2023. There I have been overseeing a research laboratory of a dozen highly talented and visionary scientists who are providing new insights into the causes and possible means of prevention of type 2 diabetes, as well as seeking a gene therapy cure for one of the world's rarest diseases - progeria, a premature aging disorder. NIH is the largest supporter of biomedical research in the world. It is the main piston of a biomedical discovery engine that is the envy of the globe. Yet it is not a household name. It should be. NIH supports everything from basic science to clinical trials, providing the foundation of many breakthroughs. When you hear about patients surviving stage 4 cancer because of immunotherapy, that was based on NIH research over many decades. When you hear about sickle cell disease being cured because of CRISPR

gene editing, that was built on many years of research supported by NIH. It has also been the largest supporter of global health research in the world, winning us many friends and colleagues from across the globe. I have loved being employed by this extraordinary, life-giving institution for 32 years. I will continue to devote my life in other ways to seeking knowledge and enhancing health, to healing disease and reducing suffering, and to doing what I can to bring together our fractured communities around the shared values of love, truth, goodness, and faith. As I depart NIH, I want to express my gratitude and love for the men and women with whom I have worked side-by-side for so many years. They are individuals of extraordinary intellect and integrity, selfless and hard-working, generous and compassionate. They personify excellence in every way, and they deserve the utmost respect and support of all Americans.

Francis Collins, longtime NIH director with bipartisan bona fides*, retires as of yesterday.

He returned to NIH in 2023 to focus on research in his own lab, in the NIH in-house intramural research campus.

His letter seems to imply he wasn’t ready to leave. NIH is being torn down. 1/🧪 #academicsky

5 Calls Spend 5 minutes. Make 5 calls. Make your voice heard.

Is there any “break glass in case of emergency” action we take?
Other than calling our representatives to yell at them?

5calls.org

NIH ban on renewing senior scientists adds to assaults on its in-house research Policy follows firings of tenure-track scientists and suspension of training programs

More tragic news about NIH and NIH science. Grant system is frozen and intramural program is being slashed. All will claw back on treatments and cures for cancer and other human diseases. This can’t be what the public wants. 🧪 www.science.org/content/arti...

Lies, Damned Lies and Trumpflation Big worries — and some investment advice

Today the CDC, tomorrow the BLS? paulkrugman.substack.com/p/lies-damne...

Opinion | Trump Wants to Destroy All Academia, Not Just the Woke Parts The administration’s war on universities defies rational self-interest.

JD Vance has expressed a “deep hostility to the entire academic enterprise, not just the so-called woke parts,” writes @michellegoldberg.bsky.social. "He wasn’t talking about making more room for right-wing ideas in universities or even dreaming of taking them over. He wanted to destroy it all."

Feels like we are all living in an idiocracy :(

Spectacular results! Consolidation #radiotherapy for gallbladder cancer improves survival and maintains quality of life.
Congratulations to the study team.

🔍 Does AI reduce #clinician workload?

@NEJM study on @NuanceDragon DAX Copilot, an AI-powered documentation tool, found minimal impact on EHR efficiency & financial metrics❗️

💡AI tools need to be developed in comjuction with 🩺🥼🧑‍⚕️ not in silos
#AIinMedicine #LLMs @oncoalert.bsky.social

What do you guys do at your institution for unresectable single lesions? We have been reserving SBRT for later due to concern for cumulative reductions in Veff. Especially in patients who may not be near transplant.

And yet another prospective trial confirming excellent efficacy of SBRT for localized HCC
- n=36 pts
- median tumor size 2.3 cm
- median FU 49 mo
- 3-year local control rate 93%
- Grade 3 AE 11%
www.redjournal.org/article/S036...

Celebrating the Treatment of Our 1000th Proton Therapy Patient - Sylvester Comprehensive Cancer Center - OncoDaily Celebrating the Treatment of Our 1000th Proton Therapy Patient - Sylvester Comprehensive Cancer Center / cancer milestones, cancer treatment innovation, Keith

oncodaily.com/blog/proton-...

We just treated our 1000th patient on our proton linac! #radonc

The RACE-GB trial results are here! FIRST randomized controlled trial investigating radiotherapy (RT) in gallbladder cancer.

In a cohort of 135 patients the addition of RT after 4 cycles of chemotherapy (compared to observation) extended overall survival (OS) from 4 months to 10 months.@RadOnc

The last session of the Miami Symposium on Human Metabolism will focus on approaches in metabolism, including mass spectrometry imaging and engineering! Speakers include Erin Seeley @utaustin.bsky.social, Jens Soltwisch and Ashutosh Agarwal! @asms.org Travel awards considered! miamimetabolism.com

#medsky #radonc I’m about to go on paternity leave. What does parental leave look like at your institution? Did you take all of it? Did it impact your compensation? How did you mitigate loss of career momentum?

😂 these are so spot on.

Sometimes the combination of arrogance and ignorance is breathtaking. Yes, US health care has high admin costs; that's because it relies so much on private insurers. Govt-run health insurance has much lower overhead

Radiation Oncology is characterized by rapid innovation

Dissemination & implementation are important aspects to bring this progress to our cancer patients in daily practice

Well written review by Erin Gillespie and colleagues 👇
www.redjournal.org/article/S036...

Locoregional Therapies for Hepatocellular Carcinoma This systematic review and meta-analysis compares findings from randomized clinical trials on the use of locoregional therapies as monotherapy or combination therapy in the treatment of nonmetastatic ...

Systematic review & meta-analysis of locoregional therapies for #HCC in @jama.com network open

✅Inclusion:
RCTs with PFS and OS as endpoints

✅Conclusions:
Resection > thermal ablation ~ RT ~ HAIC > embolization

#oncsky #radonc #radsky #liversky

ja.ma/3ONRpQ1

I can only imagine! Will have to wait for the results then

Man would love to see this trial in Miami.

Super proud of all my colleagues at James Cook University Hospital Cancer Centre who have now recruited 150 patients to the PACE-NODES trial! Huge amount of work and data collection involved. Let’s keep the momentum going. Massive thanks to all the patients. #PCSM #radonc #SBRT #SABR #NHS

Private insurance defenders, do you really believe that 1/3 of healthcare claims are for unnecessary or fraudulent things?