Rethinking cancer of unknown primary: from diagnostic challenge to targeted treatment Nature Reviews Clinical Oncology, Published online: 04 August 2025; doi:10.1038/s41571-025-01060-8Cancer of unknown primary (CUP) constitutes a diagnostic quandary and has a dismal prognosis, with standard empirical chemotherapy providing limited benefit. This Review outlines diagnostic innovations that are improving tissue-of-origin prediction as well as novel treatment strategies that have shown promise for improving outcomes in patients with CUP.

Now online!

The fight against burnout: doctors in distress “I've just started a charity. I want to prevent this from happening again.” These poignant words were shared by Amandip Sidhu during a podcast interview reflecting on the tragic death of his brother, ...

🔴Perspective:

The fight against burnout: @doctorsindistress.bsky.social

"Burnout is a silent killer that demands urgent and sustained action...Addressing this crisis requires systemic changes, collective advocacy, and compassion-driven interventions."

www.thelancet.com/journals/lan...

"WRAD is a day dedicated to uniting together to highlight the essential role of radiotherapy in treating cancer, relieving symptoms, and improving quality of life for patients" September 7, 2025! www.worldradiotherapy.org

#BookSky

#ICYMI, our Psychosocial Study Group recently released a white paper summarizing contemporary issues relating to the experience of work after a cancer diagnosis through a global lens.

Download for free here: mascc.org/wp-content/u...

This project was supported to MASCC by Allianz Trade.

Dose-escalated stereotactic radiotherapy showed no significant advantage over conventional radiotherapy for relieving pain from bone metastases.

by Mercier C, Billiet C (...) Dirix P et 9 al. in J Clin Oncol #MedSky

👉 get more here

📖 read the article: https://ascopubs.org/doi/10.1200/JCO-24-01447

Olubukola Ayodele: Congratulations to Bola Owolabi on being awarded a Commander of the Order of the British Empire - OncoDaily Olubukola Ayodele: Congratulations to Bola Owolabi on being awarded a Commander of the Order of the British Empire / Bola Owolabi, cancer, Olubukola Ayodele,

Congratulations to Bola Owolabi on being awarded a Commander of the Order of the British Empire - Olubukola Ayodele
@bookiephronesis.bsky.social

oncodaily.com/career/olubu...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews

Overall Survival and Quality-of-Life Superiority in Modern Phase 3 Oncology Trials url:https://jamanetwork.com/journals/jamaoncology/fullarticle/2834980?utm_source=bluesky&utm_campaign=content-shareicons&utm_content=article_engagement&utm_medium=social&utm_term=061225

[🧵1/2] The launch of the Ontario Health's Centre of Excellence enables organization including #ICESOntario to shift away from only identifying problems.

"We have this opportunity to be on the solutions side, and solutions require partnerships," says Dr. Paul Kurdyak.

The Onus of Proof: Evidence-Based Adoption of Advanced Radiation Therapy Technologies. www.redjournal.org/article/S036...

Exercise Extends Life for People With Cancer, Study Shows

www.nytimes.com/2025/06/01/w...

ASCO Quality Care Symposium DRIVING SOLUTIONS, IMPLEMENTING CHANGE "The ASCO Quality Care Symposium is more than just a conference-it's a gathering of passionate healthcare professionals who are dedicated to making a difference. Join us and experience the warmth, engagement, and inspiration that make this meeting so special." Fumiko Chino, MD, FASCO Radiation Oncology, MD Anderson Cancer Center Chair, 2025 ASCO Quality Care Symposium

#ASCO25: As we bid adieu to Chicago, reinvigorated from time with friends & colleagues united in a common goal against cancer...

Mark your calendars to return for #ASCOQLTY25. Let’s KEEP making a difference in cancer together!

⏰ Abstracts due 6/10‼️
📆 Chicago Fri/Sat 10/10-11

We are grateful to our ~44,000 attendees who made #ASCO25 a success & the place to be! With nearly 40% joining us from outside the U.S., we are truly a global community united by our shared goal of improving #CancerCare & pt outcomes around the world. A heartfelt ‘thank you.’ 💗

Landmark clinical trial shows exercise improves colon cancer survival In a world-first clinical trial, researchers working with the Canadian Cancer Trials Group (CCTG) and Sinclair Cancer Research Institute at Queen’s University, Kingston Health Sciences Centre (KHSC), ...

Landmark clinical trial shows exercise improves colon cancer survival. healthsci.queensu.ca/stories/news...

ASCO 2025: Structured Exercise Program Improves Survival, Outcomes in Some Patients With Colon Cancer A 3-year structured exercise program initiated soon after completion of adjuvant chemotherapy improves disease-free and overall survival, as well as patient-reported physical functioning and fitness, ...

“In patients w/stage III & high-risk stage II colon cancer, a 3-year structured exercise program initiated after completion of adjuvant chemo improves DFS, OS, patient-reported physical functioning, & health-related fitness” #ASCO25
ascopost.com/news/june-20... ascopost.com/news/june-20...

ACR Appropriateness Criteria® Lung Cancer-Surveillance After Therapy This document reviews the evidence supporting different imaging modalities and techniques used to evaluate patients with a history of lung cancer. It …

Guidance on appropriate imaging in FU after #lungcancer Rx. Highly variable in practice. Time for #commonsenseoncology www.sciencedirect.com/science/arti... @iaslc.bsky.social @astro-org.bsky.social @gerryhanna.bsky.social @drtomjohn.bsky.social @dkarikios.bsky.social @hannaradonc.bsky.social

Jim Till was not only an amazingly gracious and generous scientist, he was a true advocate for young researchers, women in science and accessibility of data. A 🇨🇦 giant.

From our @ascocancer.bsky.social @pallonccop.bsky.social - wide gaps in #PallCare access across LMIC

Grateful to work w this stellar team: @realbowtiedoc.bsky.social @tingtingzhang.bsky.social @mazietsangmd.bsky.social @darcyburbage.bsky.social & cols

ascopubs.org/doi/pdfdirec...

Text reads 'Controlled medicines are crucial to manage certain health needs like cancer pain, mental health disorders, and palliative care.'. Illustration of a bottle of medicines.

Text reads 'These medicines are carefully regulated to lower the risk of health harms caused by non-medical use.' Illustration of intravenous medicines and patient.

Text reads 'Most people still don’t have safe access to controlled medicines, even for cancer pain or end-of-life care.' Illustration of tablet strips.

Text reads 'We need to be better informed about controlled medicines that can reduce unnecessary suffering; and support their urgent, safe, and rational use to improve public health.' Illustration of tablets.

Controlled medicines such as pain relievers and sedatives are essential for managing and treating numerous health conditions. Yet, millions of people in need can’t access them.

🔗 WHO's new guideline to support urgent, safe & rational access to life-improving controlled medicines: bit.ly/4ktyVBV

🌟 Exciting news from EORTC! 🌟

Our latest commentary in @thelancetoncol.bsky.social by Eva Gamper et al. highlights the need for cancer-specific tools in economic evaluations, especially with the new EU HTA Regulation.

👉 www.eortc.org/blog/2025/05...

#CancerCare #QualityofLife
@qol.eortc.org

COMET | UK Reproducibility Network (UKRN) Universities as producers but not users of evidence - Updates from the COMET project   As the sector reimagines research culture ahead of REF 2029, we’re asking: how do universities use evidence when ...

COMET project update:

Universities produce research to guide policymaking, but rarely use external research when shaping their own policies.

Early analyses indicate that meta-research is not widely used by institutions making decisions about research culture.

www.linkedin.com/feed/update/...

Dose-escalated SBRT did not show superior pain relief compared to conventional 3D radiotherapy for bone metastases after one month.

by Mercier C, Billiet C (...) Dirix P et 9 al. in J Clin Oncol #MedSky

👉 get more here

📖 read the article: https://ascopubs.org/doi/10.1200/JCO-24-01447

Microbes and Dietary Factors Within the Gut Affecting Eubiosis and Dysbiosis

Most viewed this week from JAMA: Review summarizes current evidence regarding the human microbiome and cancer, including how the microbiota in the gut and other anatomical locations affect cancer outcomes.

https://ja.ma/43iHcl5

“To educate cancer nurses means building the workforce of tomorrow.” That is one of the lemas for tomorrow's European Cancer Nursing Day
On #ECND25, let’s commit to investing in nurse education. Better training = better outcomes.
#Cancernurse #oncologynursing

Illustration of a woman taking medicine. Text reads 'Women's healthy life expectancy is shortened by maternal conditions, breast cancer and higher rates of other health issues.' Highlighted tab at the bottom reads '2025 World Health Statistics Report'

Maternal conditions and breast cancer, as well as higher rates of health problems like back & neck pain, gynaecological diseases, migraines, depression, and anxiety, reduced women's lead in healthy life expectancy compared to men.

Learn more: bit.ly/437wz4w

The EORTC #QoLConf25 is a wrap!

Over 2 days in Barcelona, global experts united to put patients at the centre of #oncology research.

🙏Thanks to all the speakers, participants, and the organising team!

👉 www.eortc.org/blog/2025/05...

@madelinepe.bsky.social @qol.eortc.org
#GivingVoice2Patients

FaceAge deep learning model can estimate biological age from face photographs to improve survival prediction for people with cancer. Bontempi D, Zalay O et al Lancet Digital Health.

www.thelancet.com/journals/lan...

In this nationwide assessment of #EmergencyMedicaid & other state policies designed to expand #immigrant healthcare coverage, we found access to care for #UndocumentedImmigrants remains fragmented, inconsistent, & largely limited to the emergency setting.

@jama.com

jamanetwork.com/journals/jam...

Ontario Bill 13, Primary Care Act, 2025, sets out six objectives for Ontario's publicly funded primary care system. www.ola.org/en/legislati... via @janephilpott.bsky.social

50,000 lung cancer patients treated late in past 10 years - and it’s getting worse One in eight patients are currently 'long waiters' - waiting at least 104 days to start their treatment

Over the last decade, 50,000 lung cancer patients in England faced unacceptable treatment delays. The lung screening rollout and upcoming National Cancer Plan must help meet #CancerWaitingTimes targets so people affected can live longer, better lives.

Read more in @theipaper.com 👇