MeisingerLab@UniFreiburg

Synchronized assembly of the oxidative phosphorylation system controls mitochondrial respiration in yeast Correct protein stoichiometry is essential for cellular function, and mitochondrial oxidative phosphorylation presents a particular challenge that requires tight control of the electron transport chain (ETC) and ATP synthase ratio. Moretti-Horten et al. identify the MiRA platform on which ETC and ATP synthase biogenesis are synchronized by a stop-and-go mechanism.

Fantastic PhD thesis, Daiana. Well deserved summa cum laude and sensational PhD publication on the discovery of MIRA, a MEGA complex which regulates OXPHOS stoichiometry in www.cell.com/developmenta...

DYRK1A signalling synchronizes the mitochondrial import pathways for metabolic rewiring - Nature Communications Most mitochondrial proteins are imported from the cytosol via the TOM complex. Here, Marada et al. identify DYRK1A as a surveillance kinase that synchronizes the different import routes to shape the o...

Interested in how to clarify a fundamental clash in mitochondrial signalling ? Check it out at www.nature.com/articles/s41...