Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...

Historical model biases in monthly high temperature anomalies indicate under-estimation of future temperature extremes - Communications Earth & Environment Models tend to underestimate mean monthly maximum temperature anomalies by 2-3% and extreme anomalies by 11-12% over the period 1980 and 2023, which could lead to temperatures 3 °C to 5 °C higher than...

Climate models have underestimated the departure of high temperature extremes from monthly means.

If we assume these model biases persist in future projections, then the climate models are also likely underestimating the magnitude of future high temperature extremes.

www.nature.com/articles/s43...

El típic tuit d'estiu. La "Garrotxa" is different.

Linking alterations in precursor cells of brain 🧠 formation with the origin of #neuropsychiatricdiseases

#bioinformàtica #neuropsiquiatria #salutmental #autisme #Alzheimer #TalentMAR @santperelab.bsky.social @yaleneuro.bsky.social @hospitaldelmar.bsky.social

www.researchmar.net/news/742/lin...

Structural variation in 1,019 diverse humans based on long-read sequencing - Nature Intermediate-coverage long-read sequencing in 1,019 diverse humans from the 1000 Genomes Project, representing 26 populations, enables the generation of comprehensive population-scale structural variant catalogues comprising common and rare alleles.

Nature research paper: Structural variation in 1,019 diverse humans based on long-read sequencing

go.nature.com/3GI9EWC

How do epigenetic modifications contribute to human #neocortex #development? Excited to see our work out in #Neuron. We applied Epi-CyTOF and identified a novel role for PRC2 in regulating #ECM.

@crtd-tud.bsky.social @cp-neuron.bsky.social

www.sciencedirect.com/science/arti...

A thread below 👇

Sex at birth is not always random — mum’s age and genetics can play a part Families with three or more boys, for example, are more likely to have another boy than a girl as the next child.

In families with several children of the same sex, the odds of having another baby of that sex are higher than of having one of the opposite sex

go.nature.com/45caBj4

How to represent genomes in 3D?

In this paper (and video), we propose Geometric Diagrams of Genomes (GDG)—a visual grammar that aims at emulating the effect ribbon diagrams (Richardson et al 1981) had in protein structural biology. Time will tell.😅

👉🏼 genomebiology.biomedcentral.com/articles/10....

Could AI slow science? Confronting the production-progress paradox

Fabulous post by @randomwalker.bsky.social & Sayash raising the same concern many of us have about whether we're on the right track with how we're using AI for science. Everyone should read it, take a deep breath & think through the implications.

www.aisnakeoil.com/p/could-ai-s...

'Night science' is what you do when you're not sure what's the question.

500 hPa geopotential height and its anomaly for 1-25.6. from NCEP/NCAR reanalysis.

Daily sea surface temperature in Mediterranean Sea. The current values are above the recent climatology, meaning record-warm sea surface temperatures.

The Mediterranean is now warmer than it typically was in August during the recent 1982–2015 climate period.

And it’s no wonder when you look at the atmospheric circulation: a strong upper-level ridge has parked over the western Mediterranean, allowing the marine heatwave to develop.

Magnitude of current heatwave is incredible!

The forecast for tuesday shows an unprecedented area with temp. > 40°C 😱

Never before has it been so hot over such a large area (and so early!) 🔥

The vertigo of having to live like this for the rest of your life...

Data @meteofrance.com

‘Huge advances in cancer and rare diseases’: 25 years of the human genome – podcast It’s been 25 years since Bill Clinton announced one of humanity’s most important scientific achievements: the first draft of the human genome. At the time, there was a great deal of excitement about t...

‘Huge advances in cancer and rare diseases’: 25 years of the human genome 🧬

Our Director, Matt Hurles, spoke to the Guardian @scienceweekly.bsky.social podcast about the Human Genome Project, and what could be in store over the next 25 years 🎧

www.theguardian.com/science/audi...

Excited to launch our AlphaGenome API goo.gle/3ZPUeFX along with the preprint goo.gle/45AkUyc describing and evaluating our latest DNA sequence model powering the API. Looking forward to seeing how scientists use it! @googledeepmind

Less guns. More pipettes.

Quantitative measurement of phenotype dynamics during cancer drug resistance evolution using genetic barcoding - Nature Communications Understanding the dynamics of how drug resistance originates in cancer remains crucial, but it is not possible to observe them directly. Here, the authors construct a mathematical framework to infer d...

Using barcodes 📊 to track cancer 💊 resistance evolution: is it clonal selection or plasticity? @fwhiting.bsky.social‬ knows! His new "Evolutionary Informed Resistance Assays" (EIRAs) framework infers resistance evolution dynamics from barcode diversity data. www.nature.com/articles/s41... @icr.ac.uk

Finlàndia s'està mediterranitzant ...

A meme-style comic panel with three parts. Left: A stylized enhancer with a mutation, surrounded by colored blocks representing functional motifs, a neural network diagram, chromatin accessibility signal traces, and a sequence motif. Two cartoon mouse embryos below show different LacZ reporter activity patterns. Top right: A hand hovers anxiously between two red buttons labeled “Experiments” and “AI,” with the caption “HOW DO ENHANCERS REALLY WORK?” Bottom right: A sweating superhero wipes his forehead, looking stressed about the difficult choice.

Textbooks: “Enhancers are just a bunch of TFBSs”

But how do they REALLY work?

New paper with many contributors here @berkeleylab.lbl.gov, @anshulkundaje.bsky.social, @anusri.bsky.social

A 🧵 (1/n)

Free access link: rdcu.be/erD22

📢New paper out in @cellcellpress.bsky.social!
🔝CNAG revolutionizes single-cell analysis with STAMP — a technique to profile individual cells without sequencing

🔬Developed by an international team from #CNAG, @stjuderesearch.bsky.social, and the University of Adelaide

📎 www.cnag.eu/news/cnag-re...

Various cell types in tissues cooperate in networks that are disrupted in disease Gene expression reveals that different types of human cell can work as a unit. These cellular modules, found in several tissues, change during disease.

Gene expression reveals that different types of human cell can work as a unit. These cellular modules, found in several tissues, change during disease

https://go.nature.com/4kaOgad

Check out our new review with @takashi-namba.bsky.social featured on the cover of Trends in Neurosciences 👇

As expected, the Sea Surface Temperature Anomaly around western Europe was record high last month (again!).

= FINANCIAL TIMES Probability of above average near-surface temperature* 0 4— Less likely Average More likely →> 1 May to Sep period 2025-29 Nov to Mar period 2025-26 to 2029-30 Predicted temperature patterns over the years 2025-29 show a high probability of temperatures above the 1991-2020 average almost everywhere, with enhanced warming over land.

Global average temperature is expected to rise to almost 2C above preindustrial in the next five years, according to the WMO, with falls in crop yields and more than a third of the world’s population being exposed to extreme heat.

People, I'm sorry but we have to deal with this. Later is too late.

Graphic: 1000-day running average Global Mean Surface Temperature (GMST) anomaly (Copernicus ERA5 data) relative to Pre-Industrial. Graph is 1980 to May 25th 2025. Background shows Ed Hawkin's "Show Your Stripes" lines Source: https://sites.ecmwf.int/data/climatepulse/data/series/era5_daily_series_2t_global.csv How to get anomaly relative to Pre-Industrial (1850-1900): https://parisagreementtemperatureindex.com/copernicus-1850-1900-baseline-daily-gmst/ Sanity Check Sources: Below are links to Copernicus's website, with gives GMST anomalies for various months/years. If you average them (properly, taking into account number of days that each value represents) ... and add May 2025 values then you get a 1000-day running average crossing 1.5C on 25th May 2025 https://climate.copernicus.eu/surface-air-temperature-september-2022 September 2022 is around 1.2°C above the 1850-1900 level https://climate.copernicus.eu/surface-air-temperature-october-2022 Oct 2022 is around 1.2°C above the 1850-1900 level https://climate.copernicus.eu/surface-air-temperature-november-2022 Nov 2022 is around 1.2°C above the 1850-1900 level https://climate.copernicus.eu/surface-air-temperature-december-2022 Dec 2022 is around 1.2°C above the 1850-1900 level https://climate.copernicus.eu/copernicus-2023-hottest-year-record 2023 was 1.48°C warmer than the 1850-1900 pre-industrial level https://climate.copernicus.eu/global-climate-highlights-2024 2024 was ... 1.60°C warmer than the pre-industrial level https://climate.copernicus.eu/surface-air-temperature-january-2025 Jan 2025 was 1.75°C above the pre-industrial level https://climate.copernicus.eu/surface-air-temperature-february-2025 Feb 2025 was 1.59°C above the estimated 1850-1900 average https://climate.copernicus.eu/surface-air-temperature-march-2025 Mar 2025 was 1.60°C above the estimated 1850-1900 average https://climate.copernicus.eu/surface-air-temperature-april-2025 Apr 2025 was 1.51°C above the estimated 1850-1900 average

1000 Day Running Average crosses 1.5C

Details in Alt Text
#ShowYourStripes @copernicusecmwf.bsky.social

Terminal Genome Viewer (tgv), written in Rust github.com/zeqianli/tgv